In:
Journal of Surgical Oncology, Wiley, Vol. 97, No. 5 ( 2008-04), p. 456-461
Abstract:
To evaluate the correlation between histologic response and size parameters, and to analyze the prognostic importance of size parameters on metastasis‐free survival in localized osteosarcoma patients. Methods We retrospectively reviewed 331 patients with stage II osteosarcoma treated with surgery and chemotherapy. The tumor size parameters were measured and calculated based on MR images. The mean metastasis‐free interval was 77.8 months (range, 3–205 months; median, 67 months). Results Tumor size is best defined by relative tumor plane (RTP). Patients with a large tumor (RTP 〉 27.5 cm 2 /m 2 ) had a significant correlation with poor histologic response and distal femoral tumor location. The independent prognostic factors for metastasis‐free survival were American Joint Committee on Cancer (AJCC) stage, RTP, proximal humerus location, chondroblastic subtype, and poor histologic response. Conclusion The initial tumor size is closely related to histologic response and is an important prognostic factor in osteosarcoma. Tumor size is best represented by AJCC stage and RTP. These parameters may serve as a basis for risk‐adapted therapy in combined stratification with histologic response. J. Surg. Oncol. 2008;97:456–461. © 2008 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0022-4790
,
1096-9098
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
1475314-5
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