In:
Journal of Korean Neurosurgical Society, Korean Neurosurgical Society, Vol. 66, No. 5 ( 2023-09-01), p. 525-535
Abstract:
Objective : We performed an expanded multi-ethnic meta-analysis to identify associations between inflammation-related loci with intracranial aneurysm (IA) susceptibility. This meta-analysis possesses increased statistical power as it is based on the most data ever evaluated.Methods : We searched and reviewed relevant literature through electronic search engines up to August 2022. Overall estimates were calculated under the fixed- or random-effect models using pooled odds ratio (OR) and 95% confidence intervals (CIs). Subgroup analyses were performed according to ethnicity.Results : Our meta-analysis enrolled 15 studies and involved 3070 patients and 5528 controls including European, Asian, Hispanic, and mixed ethnic populations. Of 17 inflammation-related variants, the rs1800796 locus (interleukin [IL]-6) showed the most significant genome-wide association with IA in East-Asian populations, including 1276 IA patients and 1322 controls (OR, 0.65; 95% CI, 0.56–0.75; 〈 i 〉 p 〈 /i 〉 =3.24×10 〈 sup 〉 -9 〈 /sup 〉 ) under a fixed-effect model. However, this association was not observed in the European population (OR, 1.09; 95% CI, 0.80–1.47; 〈 i 〉 p 〈 /i 〉 =0.5929). Three other variants, rs16944 (IL-1β), rs2195940 (IL-12B), and rs1800629 (tumor necrosis factor-α) showed a statistically nominal association with IA in both the overall, as well as East-Asian populations (0.01 〈 〈 i 〉 p 〈 /i 〉 〈 0.05).Conclusion : Our updated meta-analysis with increased statistical power highlights that rs1800796 which maps on the IL-6 gene is associated with IA, and in particular confers a protective effect against occurrence of IA in the East-Asian population.
Type of Medium:
Online Resource
ISSN:
2005-3711
,
1598-7876
DOI:
10.3340/jkns.2023.0001
Language:
English
Publisher:
Korean Neurosurgical Society
Publication Date:
2023
detail.hit.zdb_id:
2254062-3
Permalink
