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  • Wiley  (8)
  • Cho, Sun Wook  (8)
  • 1
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    The risk of second primary malignancy is increased in differentiated thyroid cancer patients with a cumulative 131 I dose over 37 GB q
    Wiley ; 2015
    In:  Clinical Endocrinology Vol. 83, No. 1 ( 2015-07), p. 117-123
    Details
    In: Clinical Endocrinology, Wiley, Vol. 83, No. 1 ( 2015-07), p. 117-123
    Abstract: The aim of this study was to investigate the risk factors for second primary malignancy ( SPM ) diagnosed after differentiated thyroid cancer ( DTC ). Methods A total of 2468 DTC patients who underwent thyroidectomy were reviewed. SPM was defined as a non‐thyroidal malignancy, diagnosed at least 1 year after the diagnosis of thyroid cancer. Patients were divided into five groups according to cumulative 131 I dose: very high‐activity (≥37·0 GB q), high‐activity (22·3–36·9 GB q), intermediate‐activity (5·56–22·2 GB q), low‐activity (1·1–5·55 GB q) and no RAI . Results Among the 2468 patients, 61 (2·5%) had SPM s during 7·0 (1·0–33·0) years of median follow‐up. Age above 40 years, male sex and very high‐activity RAI were independent risk factors for the development of SPM . SPM ‐related mortality was highest in the very high‐activity group, while DTC ‐related mortality was highest in the high‐activity group. The overall mortality both from SPM and DTC was highest in the high‐activity group. Conclusion A cumulative 131 I dose 〈 37·0 GB q did not increase the risk of SPM . A cumulative 131 I dose ≥37·0 GB q increased the risk of SPM and SPM ‐related mortality and decreased the DTC ‐specific mortality, resulting in a similar all‐cause mortality compared with the low‐activity RAI group. Using repeated high‐dose RAI for treating RAI ‐responsive but persistent DTC patients needs careful consideration of the individual benefits from RAI vs the risk of developing SPM .
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2015.83.issue-1
    DOI: 10.1111/cen.12581
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2015
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  • 2
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    In Vivo Deletion of CAR Resulted in High Bone Mass Phenotypes in Male Mice
    Wiley ; 2014
    In:  Journal of Cellular Physiology Vol. 229, No. 5 ( 2014-05), p. 561-571
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 229, No. 5 ( 2014-05), p. 561-571
    Abstract: Constitutive androstane receptor (CAR) was originally identified as xenobiotic sensor that regulates the expression of cytochrome P450 genes. However, recent studies suggest that this nuclear receptor is also involved in the regulation of energy metabolism including glucose and lipid homeostasis. This study investigated the role of CAR in the regulation of bone mass in vivo using CAR −/− mice. Endogenous mRNA expression of CAR was observed in both primary osteoblasts and osteoclast precursors. CAR −/− mice have exhibited significant increase in whole body bone mineral density (BMD) by 9.5% ( P   〈  0.01) and 5.5% ( P   〈  0.05) at 10 and 15 weeks of age, respectively, compared with WT mice in males. Microcomputed tomography analysis of proximal tibia demonstrated a significant increase in trabecular bone volume (62.7%), trabecular number (54.1%) in male CAR −/− mice compared with WT mice. However, primary culture of calvarial cells exhibited no significant changes in osteogenic differentiation potential between CAR −/− and WT. In addition, the number of tartrate‐resistant acid‐phosphatase positive osteoclasts in the femur and serum level of CTx was not different between CAR −/− and WT mice. The higher BMD and microstructural parameters were not observed in female mice. Interestingly, serum level of testosterone in male CAR −/− mice was 2.5‐fold higher compared with WT mice and the mRNA expressions of Cyp2b9 and 2b10 in the liver, which regulate testosterone metabolism, were significantly down‐regulated in male CAR −/− mice. Furthermore, the difference in BMD between CAR −/− and WT mice disappeared at 8 weeks after performing orchiectomy. CAR −/− mice also exhibited significant increase in serum 1,25(OH) 2 D 3 levels but Cyp 27B1 which converts 25(OH)D 3 to 1,25(OH) 2 D 3 was significantly down‐regulated compared to WT mice. These results suggest that in vivo deletion of CAR resulted in higher bone mass, which appears to be a result from reduced metabolism of testosterone due to down‐regulation of Cyp2b. J. Cell. Physiol. 229: 561–571, 2014. © 2013 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v229.5
    DOI: 10.1002/jcp.24478
    Language: English
    Publisher: Wiley
    Publication Date: 2014
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    SSG: 12
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  • 3
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    Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves’ Disease
    Wiley ; 2018
    In:  International Journal of Endocrinology Vol. 2018 ( 2018), p. 1-8
    Details
    In: International Journal of Endocrinology, Wiley, Vol. 2018 ( 2018), p. 1-8
    Abstract: Objectives . Because thyroid hormone is an important determinant of body weight and basal metabolic rate, we investigated the changes in the basal metabolic rate and body composition sequentially after treatment for Graves’ disease. Methods . A prospective cohort study was performed with six women newly diagnosed with Graves’ disease. During a 52-week treatment of methimazole, body composition, resting respiratory expenditure (REE), and handgrip strength were measured consecutively. Results . After methimazole treatment, body weight was initially increased (0–8 weeks), subsequently plateaued (8–24 weeks), and gradually decreased in the later period (24–52 weeks) despite the decreased food intake. The measured REE was 40% higher than the predicted REE at baseline, and it gradually decreased after treatment. REE positively correlated with thyroid hormone levels, peripheral deiodinase activity, and thyroid’s secretory capacity. Body compositional analyses showed that the fat mass increased during an earlier period (4–12 weeks), while the lean mass increased significantly during the later period (26–52 weeks). Consistent with the lean mass changes, muscle strength also significantly increased during the later period. Conclusions . Treatment of Graves’ disease increased body weight and fat mass transiently with decreased REE. However, long-term compositional changes moved in a beneficial direction increasing lean mass and reinforcing muscle strength, following decreasing fat percentages.
    Type of Medium: Online Resource
    ISSN: 1687-8337 , 1687-8345
    URL: Article
    DOI: 10.1155/2018/9863050
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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  • 4
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    Extent of surgery did not affect recurrence during 7‐years follow‐up in papillary thyroid cancer sized 1‐4 cm: Preliminary results
    Wiley ; 2017
    In:  Clinical Endocrinology Vol. 87, No. 1 ( 2017-07), p. 80-86
    Details
    In: Clinical Endocrinology, Wiley, Vol. 87, No. 1 ( 2017-07), p. 80-86
    Abstract: There is debate whether hemithyroidectomy is sufficient for patients with papillary thyroid cancer ( PTC ) sized 1‐4 cm. Therefore, we investigated whether hemithyroidectomy affects recurrence rate compared with thyroidectomy in patients with PTC sized 1‐4 cm. Design Retrospective observational study. Patients We included 147 patients with 1‐4 cm PTC who underwent hemithyroidectomy between 2004 and 2008. They were matched with 298 patients who underwent thyroidectomy, comparing age, sex, tumour size, multiplicity, extrathyroidal extension status and lymph node ( LN ) metastasis status. Measurements Recurrence‐free survival (RFS) was compared between hemithyroidectomy and thyroidectomy groups. Results Median follow‐up length was 7 years, during which there were nine (6.1%) and 17 (5.7%) recurrences in hemithyroidectomy and thyroidectomy groups, respectively. Recurrence‐free survival in the hemithyroidectomy group was not different from that in the thyroidectomy group regardless of variant, multifocality, LN metastasis and radioactive iodine treatment. However, in subgroup analysis, hemithyroidectomy significantly increased the risk of recurrence in patients with contralateral nodules on the preoperative imaging. Conclusions Recurrence after hemithyroidectomy was not different from that after thyroidectomy during a median follow‐up of 7 years. However, because thyroidectomy might be favoured in patients with contralateral nodules at preoperative evaluation, a thorough evaluation of the contralateral thyroid lobe is necessary.
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2017.87.issue-1
    DOI: 10.1111/cen.13336
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2017
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    detail.hit.zdb_id: 2004597-9
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  • 5
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    Prognostic effects of TERT promoter mutations are enhanced by coexistence with BRAF or RAS mutations and strengthen the risk prediction by the ATA or TNM staging system in differentiated thyroid cancer patients
    Wiley ; 2016
    In:  Cancer Vol. 122, No. 9 ( 2016-05), p. 1370-1379
    Details
    In: Cancer, Wiley, Vol. 122, No. 9 ( 2016-05), p. 1370-1379
    Abstract: Prognostic effects of telomerase reverse transcriptase ( TERT ) promoter mutations are enhanced by coexistence with BRAF or RAS mutations in differentiated thyroid cancer. Genetic screening for TERT promoter mutations could strengthen the predictions of mortality and recurrence by preexisting staging systems, including the American Thyroid Association and TNM systems, particularly for high‐risk patients.
    Type of Medium: Online Resource
    ISSN: 0008-543X , 1097-0142
    URL: Issue
    URL: Article
    DOI: 10.1002/cncr.v122.9
    DOI: 10.1002/cncr.29934
    Language: English
    Publisher: Wiley
    Publication Date: 2016
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    detail.hit.zdb_id: 1429-1
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  • 6
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    FDG uptake reflects an immune‐enriched subtype of thyroid cancer: Clinical implications of imaging‐based molecular characterization
    Wiley ; 2023
    In:  Cancer Medicine Vol. 12, No. 16 ( 2023-08), p. 17068-17077
    Details
    In: Cancer Medicine, Wiley, Vol. 12, No. 16 ( 2023-08), p. 17068-17077
    Abstract: Iodine and FDG uptakes have been established as methods to define the biological properties of thyroid cancer. As various cells in the tumor microenvironment (TME) affect tumor metabolism, we investigated the association between glucose metabolism in thyroid cancer and the TME using transcriptomic analyses. Methods We used F‐18 FDG PET and RNA sequencing data of thyroid cancer to find associations between TME cell types and glucose metabolism. In addition, publicly available single‐cell RNA sequencing data of papillary thyroid cancer was used to investigate glucose metabolism in cell types of the TME. The correlations between the FDG uptake and biological properties of the TME, including glucose metabolism and tumor differentiation score (TDS) were evaluated. Estimation of the proportions of immune and cancer cells (EPIC) was performed. The biological properties of each cell type were also assessed in the single‐cell RNA sequencing data. Results FDG uptake showed a positive correlation with the enrichment score of macrophages and glycolysis activity. In single‐cell RNA sequencing, immune cells had both high glucose transporters (GLUTs) and glycolysis signatures, while thyrocytes including cancer cells showed relatively low GLUTs and glycolysis signatures, suggesting that FDG uptake mainly occurred in immune cells of the TME. Moreover, the high GLUTs of myeloid cells were negatively associated with TDS. Conclusions Our findings suggest that thyroid cancer with high FDG uptake can be mediated by enriched immune cells of the TME. We suggest that FDG uptake in thyroid cancer could be a marker for the immune‐rich type and provide clinical implications for treatment stratification.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v12.16
    DOI: 10.1002/cam4.6350
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2659751-2
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  • 7
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    Shortened telomere length in peripheral blood leukocytes is associated with cumulative radioactive iodine doses in patients with differentiated thyroid carcinoma
    Wiley ; 2024
    In:  Cancer Vol. 130, No. 12 ( 2024-06-15), p. 2215-2223
    Details
    In: Cancer, Wiley, Vol. 130, No. 12 ( 2024-06-15), p. 2215-2223
    Abstract: By assessing relative telomere length, an association between the cumulative dose of radioactive iodine and the shortening of telomeres was observed.
    Type of Medium: Online Resource
    ISSN: 0008-543X , 1097-0142
    URL: Issue
    URL: Article
    DOI: 10.1002/cncr.v130.12
    DOI: 10.1002/cncr.35256
    Language: English
    Publisher: Wiley
    Publication Date: 2024
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    detail.hit.zdb_id: 1429-1
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  • 8
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    The role of ultrasound findings in the management of thyroid nodules with atypia or follicular lesions of undetermined significance
    Wiley ; 2014
    In:  Clinical Endocrinology Vol. 80, No. 5 ( 2014-05), p. 735-742
    Details
    In: Clinical Endocrinology, Wiley, Vol. 80, No. 5 ( 2014-05), p. 735-742
    Abstract: Atypia or follicular lesions of undetermined significance ( AUS / FLUS ) is a broad cytological category in the B ethesda system for classifying thyroid cytology. This study investigated the diagnostic accuracy of ultrasound ( US ) analysis of thyroid nodules with AUS / FLUS . Patients and Methods Of 5062 subjects with nodules subjected to fine‐needle aspiration cytology ( FNAC s) at our institution from January 2010 through May 2012, 383 met the Bethesda criteria for AUS / FLUS . After excluding subjects who had a history of thyroid cancer, who only underwent repeat FNA or who underwent no further examinations, we selected 249 subjects who had subsequently undergone a core‐needle biopsy and/or surgery. Of these, 100 were found to have malignant nodules (40·2%), 122 had benign nodules (49%), and 27 had nodules with indeterminate status (10·8%). We compared specific US parameters, including size, location, content, shape, margin, echogenicity, echotexture and calcification across these subject groups. Results Multivariate analysis revealed that malignancy was associated with taller‐than‐wide shape ( TDW ) ( OR  = 8·43, P  = 0·002), ill‐defined margin ( OR  = 3·23, P  = 0·002) and marked hypoechogenicity. ( OR  = 3·61, P  = 0·001). The specificity and positive predictive values of TDW were 98% and 90·6%,respectively. The specificity and positive predictive values of ‘ TDW and marked hypoechogenicity’ were both 100%. Conclusion US findings play a complementary role in the diagnosis of thyroid nodules with AUS / FLUS . In case of highly suspicious US findings such as ‘ TDW and marked hypoechogenicity’, could be very helpful in the diagnosis of malignancy.
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2014.80.issue-5
    DOI: 10.1111/cen.12348
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2014
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