In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 2 ( 2022-2-7), p. e0263690-
Abstract:
The purpose of this study was to investigate the value of C-11 methionine (MET) positron emission tomography (PET)/computed tomography (CT) in patients with intracranial germinoma (IG). Material and methods We conducted a retrospective analysis of 21 consecutive patients with pathologically confirmed IGs and eight patients with intracranial non-germinomas (INGs) located in a similar region. Clinical characteristics, imaging findings, and tumor markers such as α-fetoprotein (AFP) and β-human chorionic gonadotropin (HCG) were used as clinical variables. Maximum standardized uptake value (SUV max ), tumor-to-normal tissue (T/N) ratio, and visual scoring of tumor were used as MET PET parameters. Results All IGs were well visualized on MET PET with a three-grade visual scoring system. In addition, SUV max of IGs was higher than that of INGs (P = 0.005). Pre-treatment (Pre-Tx) T/N ratio was significantly correlated with pre-Tx serum HCG (P = 0.031). Moreover, MET PET parameters showed significant associations with tumor location, sex, KRAS variant, and symptoms. Conclusion MET PET/CT could be a useful diagnostic tool in patients suspected of having IGs. In addition, the MET avidity of tumor is a potential surrogate biomarker of HCG, which has been used as a diagnostic marker for IGs. Tumor MET parameters also had significant differences according to tumor locations, sex, symptoms, and KRAS mutation. However, MET avidity of tumors had no significant prognostic value.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0263690
DOI:
10.1371/journal.pone.0263690.g001
DOI:
10.1371/journal.pone.0263690.g002
DOI:
10.1371/journal.pone.0263690.g003
DOI:
10.1371/journal.pone.0263690.t001
DOI:
10.1371/journal.pone.0263690.t002
DOI:
10.1371/journal.pone.0263690.t003
DOI:
10.1371/journal.pone.0263690.t004
DOI:
10.1371/journal.pone.0263690.s001
DOI:
10.1371/journal.pone.0263690.s002
DOI:
10.1371/journal.pone.0263690.s003
DOI:
10.1371/journal.pone.0263690.r001
DOI:
10.1371/journal.pone.0263690.r002
DOI:
10.1371/journal.pone.0263690.r003
DOI:
10.1371/journal.pone.0263690.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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