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  • 1
    Online Resource
    Online Resource
    SARS-CoV-2 Antibody Response and Sustainability after a Third Dose of BNT162b2 in Healthcare Workers at Health Promotion Centers
    MDPI AG ; 2023
    In:  Viruses Vol. 15, No. 3 ( 2023-03-14), p. 751-
    Details
    In: Viruses, MDPI AG, Vol. 15, No. 3 ( 2023-03-14), p. 751-
    Abstract: The aim of this study was to determine the antibody response and the sustainability of immunogenicity after a third dose of BNT162b2 (BNT) in homologous [ChAdOx1 (ChAd)/ChAd, BNT/BNT, and mRNA-1273 (Moderna)/Moderna] and heterologous (ChAd/BNT) vaccinations of two primary doses with different schemes. This prospective observational study recruited consenting healthcare workers from 16 healt h checkup centers in 13 Korean cities. Three-point blood tests were analyzed as the antibody response after the third vaccination: T3-1 (1 month after the third dose), T3-3 (3 months after the third dose), and T3-4–10 (4–10 months after the third dose). SARS-CoV-2 antibodies were measured using a chemiluminescence microparticle immunoassay with SARS-CoV-2 IgG II Quant in the ARCHITECT system (Abbott Diagnostics). The antibody levels were significantly higher in the Moderna /Moderna and BNT/BNT groups than in the ChAd/ ChAd and ChAd/BNT groups (p 〈 0.05) at T3-1. At T3-3, antibody levels had decreased by 29.1% in the BNT/BNT group and by 45.3% in the ChAd/ChAd group compared with the antibody levels at T3-1. The anti-SARS-CoV-2 S-RBD IgG levels at T3-1 were significantly associated with having received mRNA vaccines as the two primary doses (p 〈 0.001). The third dose of BNT induced an increased humoral immune response in various vaccination schemes, which was more prominent for the two primary doses of homologous mRNA vaccines. However, this immunogenicity decreased within 3–10 months after the third dose. These results suggest that another booster dose (a fourth dose), which would be able to counteract SARS-CoV-2 variants, is needed.
    Type of Medium: Online Resource
    ISSN: 1999-4915
    URL: Article
    DOI: 10.3390/v15030751
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2516098-9
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  • 2
    Online Resource
    Online Resource
    Comparison of Traditional and Reverse Syphilis Screening Algorithms in Medical Health Checkups
    Annals of Laboratory Medicine ; 2017
    In:  Annals of Laboratory Medicine Vol. 37, No. 6 ( 2017-11-01), p. 511-515
    Details
    In: Annals of Laboratory Medicine, Annals of Laboratory Medicine, Vol. 37, No. 6 ( 2017-11-01), p. 511-515
    Type of Medium: Online Resource
    ISSN: 2234-3806 , 2234-3814
    URL: Article
    DOI: 10.3343/alm.2017.37.6.511
    Language: English
    Publisher: Annals of Laboratory Medicine
    Publication Date: 2017
    detail.hit.zdb_id: 2677441-0
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  • 3
    Online Resource
    Online Resource
    Complete Blood Count Reference Intervals and Patterns of Changes Across Pediatric, Adult, and Geriatric Ages in Korea
    Annals of Laboratory Medicine ; 2018
    In:  Annals of Laboratory Medicine Vol. 38, No. 6 ( 2018-11-28), p. 503-511
    Details
    In: Annals of Laboratory Medicine, Annals of Laboratory Medicine, Vol. 38, No. 6 ( 2018-11-28), p. 503-511
    Type of Medium: Online Resource
    ISSN: 2234-3806 , 2234-3814
    URL: Article
    DOI: 10.3343/alm.2018.38.6.503
    Language: English
    Publisher: Annals of Laboratory Medicine
    Publication Date: 2018
    detail.hit.zdb_id: 2677441-0
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  • 4
    Online Resource
    Online Resource
    Nationwide seroprevalence of antibodies to SARS-CoV-2 in asymptomatic population in South Korea: a cross-sectional study
    BMJ ; 2021
    In:  BMJ Open Vol. 11, No. 4 ( 2021-04), p. e049837-
    Details
    In: BMJ Open, BMJ, Vol. 11, No. 4 ( 2021-04), p. e049837-
    Abstract: Asymptomatic active infection might be an important contributor to the COVID-19 outbreak. Serological tests can assess the extent of exposure and herd immunity to COVID-19 in general populations. This study aimed to estimate the nationwide seroprevalence of SARS-CoV-2 antibodies according to age, sex and clinical status in South Korea. Design, setting and participants This cross-sectional study randomly selected health examinees who underwent health check-up at 16 health promotion centres in 13 Korean cities across the country between late September and early December 2020. Residual serum samples were obtained from 4085 subjects (2014 men and 2071 women). Antibodies to SARS-CoV-2 were measured by electrochemiluminescence immunoassay using Elecsys Anti-SARS-CoV-2 (Roche Elecsys, Mannheim, Germany). Primary and secondary outcome measures Fisher’s exact test was used to compare the seroprevalence according to sex, age group and region. The relative risks of being seropositive according to the characteristics of the study subjects were analysed using logistic regression analysis. Results The overall seroprevalence of anti-SARS-CoV-2 was 0.39% (95% CI=0.20% to 0.58%): 0.30% (95% CI=0.06% to 0.54%) for men and 0.48% (95% CI=0.18% to 0.78%) for women. The rate of anti-SARS-CoV-2 positivity varied significantly between different regions of Korea (p=0.003), but not with age group, sex, or the statuses of obesity, diabetes, hypertension or smoking. Conclusions Most of the Korean population is still immunologically vulnerable to SARS-CoV-2, but the seroprevalence has increased relative to that found in studies performed prior to September 2020 in Korea.
    Type of Medium: Online Resource
    ISSN: 2044-6055 , 2044-6055
    URL: Article
    DOI: 10.1136/bmjopen-2021-049837
    Language: English
    Publisher: BMJ
    Publication Date: 2021
    detail.hit.zdb_id: 2599832-8
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  • 5
    Online Resource
    Online Resource
    Plasma NT-proBNP levels associated with cardiac structural abnormalities in asymptomatic health examinees with preserved ejection fraction: a retrospective cross-sectional study
    BMJ ; 2019
    In:  BMJ Open Vol. 9, No. 4 ( 2019-04), p. e026030-
    Details
    In: BMJ Open, BMJ, Vol. 9, No. 4 ( 2019-04), p. e026030-
    Abstract: Stage B heart failure (HF) is defined as an asymptomatic abnormality of the heart structure or function. The circulating level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) is elevated in symptomatic patients with left ventricular (LV) dysfunction caused by a structural or functional abnormality. This study investigated the association of the NT-proBNP level with echocardiography-detected cardiac structural or diastolic abnormalities in asymptomatic subjects with preserved LV systolic function (ejection fraction 〉 50%). Methods We retrospectively studied 652 health examinees who underwent echocardiography and an NT-proBNP test at a health-promotion centre in Seoul, between January 2016 and September 2018. The left ventricular mass index (LVMI) and the left atrial dimension (LAD) were used as markers for structural abnormalities, and the mean e’ velocity and mitral early flow velocity/early diastolic tissue velocity (E/e’) ratio were used as markers for diastolic dysfunction. The plasma NT-proBNP level was measured using electrochemiluminescence immunoassay (DPC Immulite 2000 XPi, Siemens Healthcare Diagnostics, Tarrytown, New York, USA). Results Subjects with preclinical structural abnormalities were older and had a higher body mass index (BMI), higher blood pressure, lower high-density lipoprotein cholesterol level, higher NT-proBNP level, and higher E/e’ (p 〈 0.05). Multivariate regression analysis indicated that the factors associated with a higher NT-proBNP level were older age, female sex, lower BMI, higher creatinine level, higher LVMI and higher LAD (p 〈 0.01). Conclusion Diastolic dysfunction is not associated with higher NT-proBNP levels, whereas preclinical cardiac structural abnormalities, as well as older age, female sex, lower BMI, and higher creatinine level, are associated with higher NT-proBNP levels.
    Type of Medium: Online Resource
    ISSN: 2044-6055 , 2044-6055
    URL: Article
    DOI: 10.1136/bmjopen-2018-026030
    Language: English
    Publisher: BMJ
    Publication Date: 2019
    detail.hit.zdb_id: 2599832-8
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  • 6
    Online Resource
    Online Resource
    A novel quantitative evaluation method for quality control results
    Elsevier BV ; 2015
    In:  Clinica Chimica Acta Vol. 451 ( 2015-12), p. 175-179
    Details
    In: Clinica Chimica Acta, Elsevier BV, Vol. 451 ( 2015-12), p. 175-179
    Type of Medium: Online Resource
    ISSN: 0009-8981
    URL: Article
    DOI: 10.1016/j.cca.2015.09.026
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2015
    detail.hit.zdb_id: 1499920-1
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  • 7
    Online Resource
    Online Resource
    The Reproducibility and Usefulness of Estimated Average Glucose for Hyperglycemia Management during Health Checkups: A Retrospective Cross-Sectional Study
    MDPI AG ; 2022
    In:  Healthcare Vol. 10, No. 5 ( 2022-04-29), p. 824-
    Details
    In: Healthcare, MDPI AG, Vol. 10, No. 5 ( 2022-04-29), p. 824-
    Abstract: HbA1c reflects average glucose levels over 3 months, but it does not measure glycemic variability. This study aimed to determine the reproducibility and usefulness of HbA1c-derived estimated average glucose (eAG) and to analyze the factors associated with eAG during health checkups. This cross-sectional retrospective study consecutively selected subjects who had undergone health checkups at 16 health-promotion centers in 13 Korean cities in 2020. The subjects comprised 182,848 healthy subjects with normoglycemia, 109,555 with impaired fasting glucose (IFG), and 35,632 with diabetes. eAG was calculated using Nathan’s regression equation. In all subjects, fasting plasma glucose (FPG) was found to be fairly strongly correlated with eAG (r = 0.811). When the subjects were divided into FPG subgroups, the strength of the correlation decreased among those with normoglycemia and IFG (p 〈 0.001). Higher eAG levels were associated with older age, females, higher FPG, and lower HDL-C and triglycerides (p 〈 0.05). The proportion of subjects with a higher value of FPG than eAG was 46.3% in poorly controlled diabetic patients, compared with only 1.5% in normoglycemic subjects. This suggests eAG could help patients to understand their glycemic variability intuitively and healthcare providers to identify patients who might worsen in hyperglycemia control through measuring the difference between eAG and FPG.
    Type of Medium: Online Resource
    ISSN: 2227-9032
    URL: Article
    DOI: 10.3390/healthcare10050824
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2721009-1
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  • 8
    Online Resource
    Online Resource
    Prevalence of liver fibrosis and associated risk factors in the Korean general population: a retrospective cross-sectional study
    BMJ ; 2021
    In:  BMJ Open Vol. 11, No. 3 ( 2021-03), p. e046529-
    Details
    In: BMJ Open, BMJ, Vol. 11, No. 3 ( 2021-03), p. e046529-
    Abstract: The health burden of chronic liver disease is increasing worldwide. Its main histological consequence is liver fibrosis, and eventually cirrhosis. This process is rarely diagnosed at the pre-cirrhotic stage due to it being asymptomatic. Little is known about the prevalence of liver fibrosis and associated risk factors in the general population. The aims of this study were to determine the prevalence and distribution of liver fibrosis using magnetic resonance elastography (MRE), as well as the risk factors associated with liver fibrosis in the asymptomatic general population. Design, setting and participants This cross-sectional retrospective study consecutively selected subjects who underwent health check-ups including MRE at 13 health promotion centres in Korea between 2018 and 2020. Liver fibrosis was estimated using MRE with cut-off values for significant and advanced liver fibrosis of 2.90 and 3.60 kPa, respectively. Primary and secondary outcome measures The Χ 2 test was used to compare the prevalence of liver fibrosis according to sex and age groups. Multivariable logistic regression analyses were performed to identify the factors for significant and advanced liver fibrosis. Results Among the 8183 subjects, 778 (9.5%) had ≥significant fibrosis (≥2.9 kPa), which included 214 (2.6%) subjects with ≥advanced fibrosis (≥3.6 kPa). Multivariable analysis revealed that liver fibrosis was associated with age (OR=1.34, 95% CI=1.18 to 1.51), male sex (OR=3.18, 95% CI=1.97 to 5.13), diabetes (OR=2.43, 95% CI=1.8 to 3.28), HBsAg positivity (OR=3.49, 95% CI=2.55 to 4.79), abnormal liver function test (OR=1.9, 95% CI=1.49 to 2.42) and obesity (OR=1.77, 95% CI=1.35 to 2.32) (all p 〈 0.001), as well as metabolic syndrome (OR=1.4, 95% CI=1.05 to 1.87) (p=0.024). Conclusions The prevalence of significant or more liver fibrosis was high in the Korean general population and much higher among individuals with risk factors. This suggests that screening of liver fibrosis should be considered in general population, especially among high-risk groups.
    Type of Medium: Online Resource
    ISSN: 2044-6055 , 2044-6055
    URL: Article
    DOI: 10.1136/bmjopen-2020-046529
    Language: English
    Publisher: BMJ
    Publication Date: 2021
    detail.hit.zdb_id: 2599832-8
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  • 9
    Online Resource
    Online Resource
    Comparison of Urine Albumin-to-Creatinine Ratio (ACR) Between ACR Strip Test and Quantitative Test in Prediabetes and Diabetes
    Annals of Laboratory Medicine ; 2017
    In:  Annals of Laboratory Medicine Vol. 37, No. 1 ( 2017-01-01), p. 28-33
    Details
    In: Annals of Laboratory Medicine, Annals of Laboratory Medicine, Vol. 37, No. 1 ( 2017-01-01), p. 28-33
    Type of Medium: Online Resource
    ISSN: 2234-3806 , 2234-3814
    URL: Article
    DOI: 10.3343/alm.2017.37.1.28
    Language: English
    Publisher: Annals of Laboratory Medicine
    Publication Date: 2017
    detail.hit.zdb_id: 2677441-0
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  • 10
    Online Resource
    Online Resource
    Human Papillomavirus Genotype Distribution Among 18,815 Women in 13 Korean Cities and Relationship With Cervical Cytology Findings
    Annals of Laboratory Medicine ; 2017
    In:  Annals of Laboratory Medicine Vol. 37, No. 5 ( 2017-09-01), p. 426-433
    Details
    In: Annals of Laboratory Medicine, Annals of Laboratory Medicine, Vol. 37, No. 5 ( 2017-09-01), p. 426-433
    Type of Medium: Online Resource
    ISSN: 2234-3806 , 2234-3814
    URL: Article
    DOI: 10.3343/alm.2017.37.5.426
    Language: English
    Publisher: Annals of Laboratory Medicine
    Publication Date: 2017
    detail.hit.zdb_id: 2677441-0
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