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  • S. Karger AG  (3)
  • 1
    Online Resource
    Online Resource
    S. Karger AG ; 2020
    In:  Ophthalmologica Vol. 243, No. 1 ( 2020), p. 43-50
    In: Ophthalmologica, S. Karger AG, Vol. 243, No. 1 ( 2020), p. 43-50
    Abstract: 〈 b 〉 〈 i 〉 Purpose: 〈 /i 〉 〈 /b 〉 To evaluate the visual prognostic factors in patients with pseudophakic epiretinal membrane (ERM) after vitrectomy using spectral domain optical coherence tomography (SD-OCT). 〈 b 〉 〈 i 〉 Method: 〈 /i 〉 〈 /b 〉 A retrospective review of patients with pseudophakic ERM having undergone vitrectomy was conducted. Best corrected visual acuity (BCVA) and SD-OCT were conducted before and 1, 3, and 6 months after vitrectomy. Known visual prognostic factors, such as inner-retina irregularity index, central foveal thickness (CFT), central inner retinal layer thickness (CIRLT), cone outer segment tip defect length, and photoreceptor outer segment length, were reviewed and their correlation with BCVA was analyzed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Forty-three patients (mean age: 64.88 ± 10.46 years) with pseudophakic ERM were included. BCVA significantly improved after vitrectomy (logMAR 0.30 ± 0.24 vs. 0.11 ± 0.14, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). The preoperative high inner-retina irregularity index significantly correlated with poor postoperative BCVA in patients with pseudophakic ERM (correlation coefficient 0.583, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). Postoperative improvements of inner retinal SD-OCT findings, such as inner-retina irregularity index, CFT, and CIRLT, were significantly associated with the amount of BCVA improvement after ERM surgery (correlation coefficients were as follows: inner-retina irregularity index – 0.711, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001; CFT – 0.462, 〈 i 〉 p 〈 /i 〉 = 0.002; CIRLT – 0.596, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). However, preoperative outer retinal SD-OCT findings were not associated with postoperative visual prognosis. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 From this study, we determined the visual prognostic factors of ERM surgery without confounding factors, such as visual acuity improvement following combined cataract surgery, and inner retinal SD-OCT findings more significantly associated with the visual prognosis of ERM surgery compared to outer retinal SD-OCT findings.
    Type of Medium: Online Resource
    ISSN: 0030-3755 , 1423-0267
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1483531-9
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  • 2
    In: Ophthalmologica, S. Karger AG, Vol. 242, No. 1 ( 2019), p. 22-30
    Abstract: We aimed to correlate the visual function and structural characteristics of the retina and choroid in advanced retinitis pigmentosa (RP) patients. A cross-sectional, retrospective review was conducted of medical records of 149 RP patients who reported visual field constriction on a central 30-2 Humphrey visual field chart. Using spectral domain-optical coherence tomography, central foveal thickness (CFT), ellipsoid zone (EZ) length, macular volume (MV), and submacular choroidal thickness (SMChT) were measured. A control cohort (68 eyes of 68 patients) was included for comparing the macular structure. Quantitative correlations between visual function indices [visual field index (VFI) and best-corrected visual acuity (BCVA)] and structural indices (CFT, EZ length, and SMChT) were evaluated. Mean age was 46.3 ± 15.5 years; mean illness duration was 60.7 ± 60.0 months. SMChT was thinner than that in normal controls. Per Pearson’s correlation, BCVA and VFI exhibited a progressive worsening related to age and disease duration. In multivariate linear regression, BCVA and VFI were significantly correlated with CFT, EZ length, and MV at the central 1-mm area. Among RP patients with visual field constriction within 30°, VFI and BCVA closely correlate with the degree of retinal structural change, including the CFT, EZ length, and MV. SMChT uniformly decreased in this study population and exhibited no significant correlation with BCVA or VFI degree.
    Type of Medium: Online Resource
    ISSN: 0030-3755 , 1423-0267
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1483531-9
    Location Call Number Limitation Availability
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  • 3
    In: Ophthalmologica, S. Karger AG, Vol. 237, No. 3 ( 2017), p. 128-138
    Abstract: 〈 b 〉 〈 i 〉 Purpose: 〈 /i 〉 〈 /b 〉 The aim of this study was to determine the correlation between the duration of myopic choroidal neovascularization (CNV) and treatment outcome after anti-vascular endothelial growth factor (VEGF) injections. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We performed a retrospective review of treatment-naïve myopic CNV patients who were treated with anti-VEGF and followed for at least 24 months to identify factors predicting final outcome and recurrence. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among 106 eyes, a shorter duration of CNV was a significant predictor of a better final best-corrected visual acuity, even after controlling for other factors ( 〈 i 〉 p 〈 /i 〉 = 0.042). When divided into 3 groups according to CNV duration before treatment ( 〈 2, 2-8, and 8-24 weeks), the recurrence rate (19, 25, and 52%, respectively; 〈 i 〉 p 〈 /i 〉 = 0.006) and number of injections (3.5, 4.0, and 5.5, respectively; 〈 i 〉 p = 〈 /i 〉 0.021) were significantly lower in eyes with a shorter duration of CNV. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Early anti-VEGF treatment of myopic CNV decreased the recurrence rate and number of injections and improved visual outcome.
    Type of Medium: Online Resource
    ISSN: 0030-3755 , 1423-0267
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1483531-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
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