In:
International Journal of Cancer, Wiley, Vol. 138, No. 12 ( 2016-06-15), p. 2884-2893
Abstract:
What's new? Methylation patterns hold clues to the risk of disease progression in men with prostate cancer. Whether risk of malignant transformation from benign prostatic disease can be similarly deduced is unknown. Here, methylation patterns in gene promoter regions were analyzed in benign tissue samples collected from men who later developed prostate cancer. In white men only, methylation of a known tumor suppressor gene in premalignant benign prostate was associated with an increased risk for subsequent disease progression. The results suggest that race‐specific methylation panels could play a role in the early detection of aggressive prostate cancer.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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