In:
Natural Product Communications, SAGE Publications, Vol. 13, No. 12 ( 2018-12), p. 1934578X1801301-
Abstract:
Hemiasterlin is a potent antimitotic agent acting through inhibition of microtubule depolymerization. For this reason, the synthesis of new hemiasterlin derivatives has attracted a lot of interest in the organic chemistry community recently. In this paper, the synthesis and evaluation of the cytotoxicity of new simplified and racemic hemiasterlin derivatives were reported. All of the synthesized analogues were evaluated in vitro for cytotoxic activity against four human cell lines (KB, Hep-G 2 , LU and MCF 7 ). Most of these analogues possess a strong cytotoxic activity on two human cancer cell lines (KB and Hep-G 2 ) and very weak activity on LU and MCF 7 cell lines.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X1801301225
Language:
English
Publisher:
SAGE Publications
Publication Date:
2018
detail.hit.zdb_id:
2430442-6
SSG:
15,3
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