In:
NeuroReport, Ovid Technologies (Wolters Kluwer Health), Vol. 34, No. 11 ( 2023-08-24), p. 546-550
Abstract:
Tau protein accumulation in the brain is thought to be one of the causes of Alzheimer’s disease (AD). Recent studies found that the choroid plexus (CP) has a role in β-amyloid and tau protein clearance in the brain. We evaluated the relationships between CP volume and the ß-amyloid and tau protein depositions. Participants were 20 patients with AD and 35 healthy subjects who underwent MRI and PET scanning using the ß-amyloid tracer 11 C-PiB and the tau/inflammatory tracer 18 F-THK5351. We computed the volume of the CP and estimated the relationships between the CP volume and ß-amyloid and tau protein/inflammatory deposition by Spearman’s correlation test. The CP volume was significantly positively correlated with both the standardized uptake value ratio (SUVR) of 11 C-PiB and the SUVR of 18 F-THK5351 in all participants. The CP volume was also significantly positively correlated with the SUVR of 18 F-THK5351in patients with AD. Our data suggested that the volume of the CP was a good biomarker for the evaluation of tau deposition and neuroinflammation.
Type of Medium:
Online Resource
ISSN:
0959-4965
DOI:
10.1097/WNR.0000000000001923
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2023
detail.hit.zdb_id:
2031485-1
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