In:
HPB Surgery, Hindawi Limited, Vol. 2017 ( 2017-08-29), p. 1-8
Abstract:
Objective . To study the correlations and discrepancies between Child-Pugh system and indocyanine green (ICG) clearance test in assessing liver function reserve and explore the possibility of combining two systems to gain an overall liver function assessment. Design . Retrospective analysis of 2832 hepatocellular carcinoma (HCC) patients graded as Child-Pugh A and Child-Pugh B with ICG clearance test being performed was conducted. Results . ICG retention rate at 15 minutes (ICG15) correlates with Child-Pugh score, however, with a large variance. Platelet count improves the correlation between Child-Pugh score and ICG15. ICG15 can be estimated using the following regression formula: estimated ICG15 (eICG15) = 45.1 + 0.435 × bilirubin − 0.917 × albumin + 0.491 × prothrombin time − 0.0283 × platelet ( R 2 = 0.455 ). Patients with eICG15 〉 20.0% who underwent major hepatectomy had a tendency towards more posthepatectomy liver failure (4.1% versus 8.0%, p = 0.09 ) and higher in-hospital mortality (3.7% versus 8.0%, p = 0.052 ). They also had shorter median overall survival ( 5.10 ± 0.553 versus 3.01 ± 0.878 years, p = 0.015 ) and disease-free survival ( 1.37 ± 0.215 versus 0.707 ± 0.183 years, p = 0.018 ). Conclusion . eICG15 can be predicted from Child-Pugh parameters and platelet count. eICG15 correlates with in-hospital mortality after major hepatectomy and predicts long-term survival.
Type of Medium:
Online Resource
ISSN:
0894-8569
,
1607-8462
DOI:
10.1155/2017/2948030
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2017
detail.hit.zdb_id:
2031561-2
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