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  • MDPI AG  (11)
  • Cheng, Yingying  (11)
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  • MDPI AG  (11)
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Language
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  • 1
    Online Resource
    Online Resource
    Synthesis and Biological Evaluation of Novel Synthetic Indolone Derivatives as Anti-Tumor Agents Targeting p53-MDM2 and p53-MDMX
    MDPI AG ; 2022
    In:  Molecules Vol. 27, No. 12 ( 2022-06-09), p. 3721-
    Details
    In: Molecules, MDPI AG, Vol. 27, No. 12 ( 2022-06-09), p. 3721-
    Abstract: A series of novel indolone derivatives were synthesized and evaluated for their binding affinities toward MDM2 and MDMX. Some compounds showed potent MDM2 and moderate MDMX activities. Among them, compound A13 exhibited the most potent affinity toward MDM2 and MDMX, with a Ki of 0.031 and 7.24 μM, respectively. A13 was also the most potent agent against HCT116, MCF7, and A549, with IC50 values of 6.17, 11.21, and 12.49 μM, respectively. Western blot analysis confirmed that A13 upregulated the expression of MDM2, MDMX, and p53 by Western blot analysis. These results indicate that A13 is a potent dual p53-MDM2 and p53-MDMX inhibitor and deserves further investigation.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules27123721
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2008644-1
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  • 2
    Online Resource
    Online Resource
    Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels
    MDPI AG ; 2019
    In:  International Journal of Molecular Sciences Vol. 20, No. 22 ( 2019-11-08), p. 5573-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 20, No. 22 ( 2019-11-08), p. 5573-
    Abstract: Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels in a variety of ways. They play important roles in biological processes such as chromatin remodeling, transcriptional activation, transcriptional interference, RNA processing, and mRNA translation. lncRNAs have important functions in plant growth and development; biotic and abiotic stress responses; and in regulation of cell differentiation, the cell cycle, and the occurrence of many diseases in humans and animals. In this review, we summarize the functions and mechanisms of lncRNAs in plants, humans, and animals at different regulatory levels.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms20225573
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Passive Daytime Radiative Cooling of Silica Aerogels
    MDPI AG ; 2023
    In:  Nanomaterials Vol. 13, No. 3 ( 2023-01-24), p. 467-
    Details
    In: Nanomaterials, MDPI AG, Vol. 13, No. 3 ( 2023-01-24), p. 467-
    Abstract: Silica aerogels are one of the most widely used aerogels, exhibiting excellent thermal insulation performance and ultralow density. However, owing to their plenitude of Si-O-Si bonds, they possess high infrared emissivity in the range of 8–13 µm and are potentially robust passive radiative cooling (PRC) materials. In this study, the PRC behavior of traditional silica aerogels prepared from methyltrimethoxysilane (MTMS) and dimethyldimethoxysilane (DMDMS) in outdoor environments was investigated. The silica aerogels possessed low thermal conductivity of 0.035 W/m·K and showed excellent thermal insulation performance in room environments. However, sub-ambient cooling of 12 °C was observed on a clear night and sub-ambient cooling of up to 7.5 °C was achieved in the daytime, which indicated that in these cases the silica aerogel became a robust cooling material rather than a thermal insulator owing to its high IR emissivity of 0.932 and high solar reflectance of 0.924. In summary, this study shows the PRC performance of silica aerogels, and the findings guide the utilization of silica aerogels by considering their application environments for achieving optimal thermal management behavior.
    Type of Medium: Online Resource
    ISSN: 2079-4991
    URL: Article
    DOI: 10.3390/nano13030467
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662255-5
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  • 4
    Online Resource
    Online Resource
    Dynamic Research on Three-Player Evolutionary Game in Waste Product Recycling Supply Chain System
    MDPI AG ; 2022
    In:  Systems Vol. 10, No. 5 ( 2022-10-13), p. 185-
    Details
    In: Systems, MDPI AG, Vol. 10, No. 5 ( 2022-10-13), p. 185-
    Abstract: Recycling channel construction plays an important role in the development of closed-loop supply chains. In particular, the emergence of online recycling channels has made up for the shortcomings of traditional recycling channels with poor information and limited markets. This paper constructs an evolutionary game model to investigate the cooperation between manufacturers and e-commerce platforms with government intervention or not. The result shows that whether an enterprise actively participates in the cooperative recycling depends on the actual cost of establishing the cooperative recycling system. Additionally, the government support and supervision will affect the actual cost of cooperation. When the actual cost of establishing a collaborative recovery system is very large, under the influence of government interventions, there will be two kinds of evolutionary results for enterprises, either with cooperation or not at the same time. On the contrary, when the actual cost is small or medium, both manufacturers and the platforms will choose to cooperate. Thus, government participation in a cooperative recovery system is the best strategic option.
    Type of Medium: Online Resource
    ISSN: 2079-8954
    URL: Article
    DOI: 10.3390/systems10050185
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2663185-4
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  • 5
    Online Resource
    Online Resource
    Analysis of Omni-Channel Evolution Game Strategy for E-Commerce Enterprises in the Context of Online and Offline Integration
    MDPI AG ; 2023
    In:  Systems Vol. 11, No. 7 ( 2023-06-23), p. 321-
    Details
    In: Systems, MDPI AG, Vol. 11, No. 7 ( 2023-06-23), p. 321-
    Abstract: With the upgrading of people’s consumption patterns, the omni-channel supply chain becomes the mainstream form of e-commerce platform enterprise development. Aiming at two different e-commerce enterprises, we construct an evolutionary game model for enterprises’ “online+offline” omni-channel construction strategy by self-build or cooperating with brick-and-mortar stores. It is based on the Stackelberg and Cournot competition model, combined with the omni-channel pricing strategy, using the theory of perfect rationality and bounded rationality, and combing the non-cooperative game and evolutionary game to realize. Moreover, the evolutionary game process is simulated. Through the dynamic changes of the system, the strategy selection behavior mechanism of the retail channel subjects is deeply analyzed. It is found that enterprises’ strategy choices are influenced by both competitors and profits, and evolutionary stabilization strategies are not unique. In addition, changes in consumer loyalty, physical feelings, and sharing ratio during the evolutionary process will affect the stability rate of enterprises’ behavioral choices.
    Type of Medium: Online Resource
    ISSN: 2079-8954
    URL: Article
    DOI: 10.3390/systems11070321
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2663185-4
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  • 6
    Online Resource
    Online Resource
    The Catalase Gene Family in Cotton: Genome-Wide Characterization and Bioinformatics Analysis
    MDPI AG ; 2019
    In:  Cells Vol. 8, No. 2 ( 2019-01-24), p. 86-
    Details
    In: Cells, MDPI AG, Vol. 8, No. 2 ( 2019-01-24), p. 86-
    Abstract: Catalases (CATs), which were coded by the catalase gene family, were a type notably distinguished ROS-metabolizing proteins implicated to perform various physiological functions in plant growth, development and stress responses. However, no systematical study has been performed in cotton. In the present study, we identified 7 and 7 CAT genes in the genome of Gossypium hirsutum L. Additionally, G. barbadense L., respectively. The results of the phylogenetic and synteny analysis showed that the CAT genes were divided into two groups, and whole-genome duplication (WGD) or polyploidy events contributed to the expansion of the Gossypium CAT gene family. Expression patterns analysis showed that the CAT gene family possessed temporal and spatial specificity and was induced by the Verticillium dahliae infection. In addition, we predicted the putative molecular regulatory mechanisms of the CAT gene family. Based on the analysis and preliminary verification results, we hypothesized that the CAT gene family, which might be regulated by transcription factors (TFs), alternative splicing (AS) events and miRNAs at different levels, played roles in cotton development and stress tolerance through modulating the reactive oxygen species (ROS) metabolism. This is the first report on the genome-scale analysis of the cotton CAT gene family, and these data will help further study the roles of CAT genes during stress responses, leading to crop improvement.
    Type of Medium: Online Resource
    ISSN: 2073-4409
    URL: Article
    DOI: 10.3390/cells8020086
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2661518-6
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  • 7
    Online Resource
    Online Resource
    Plant MicroRNAs in Cross-Kingdom Regulation of Gene Expression
    MDPI AG ; 2018
    In:  International Journal of Molecular Sciences Vol. 19, No. 7 ( 2018-07-10), p. 2007-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 19, No. 7 ( 2018-07-10), p. 2007-
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms19072007
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Electrospun Nanofiber Materials for Photothermal Interfacial Evaporation
    MDPI AG ; 2023
    In:  Materials Vol. 16, No. 16 ( 2023-08-18), p. 5676-
    Details
    In: Materials, MDPI AG, Vol. 16, No. 16 ( 2023-08-18), p. 5676-
    Abstract: Photothermal interfacial evaporation with low cost and environmental friendliness has attracted much attention. However, there are still many problems with this technology, such as heat loss and salt accumulation. Due to their different structures and adjustable chemical composition, electrospun nanofiber materials generally exhibit some unique properties that provide new approaches to address the aforementioned issues. In this review, the rational design principles for improving the total efficiency of solar evaporation are described for thermal/water management systems and salt-resistance strategies. And we review the state-of-the-art advancements in photothermal evaporation based on nanofiber materials and discuss their derivative applications in desalination, water purification, and power generation. Finally, we highlight key challenges and opportunities in both fundamental research and practical applications to inform further developments in the field of interfacial evaporation.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma16165676
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2487261-1
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  • 9
    Online Resource
    Online Resource
    River Chief System, Emission Abatement, and Firms’ Profits: Evidence from China’s Polluting Firms
    MDPI AG ; 2022
    In:  Sustainability Vol. 14, No. 6 ( 2022-03-15), p. 3418-
    Details
    In: Sustainability, MDPI AG, Vol. 14, No. 6 ( 2022-03-15), p. 3418-
    Abstract: This paper studies the firm-level impact of the river chief system (RCS), which is a decentralized policy in China for water protection, by investigating polluting firms’ emission abatement and the net operating profits. We have four main findings. First, on average, the RCS significantly reduced firm-level COD emissions by 3.7 percent, which was mainly caused by the emission abatement of firms in heavily polluting industries, non-state-owned firms, and firms in the eastern provinces. On the other hand, the RCS also significantly increased polluting firms’ profit by 3.1 percent, which was mainly caused by heavily polluting firms. Second, different regions adopted different strategies for pollution abatement, exhibiting a pattern consistent with the “pollution paradise” assumption in the central and western provinces. Third, polluting firms at provincial boundaries did not reduce their COD emissions, while polluting firms in the interior significantly reduced their emissions by 5.6 percent, indicating the strong free-riding incentive of local governments. Fourth, the increase in the profits of heavily polluting industries was mainly caused by the significant increase in market concentration and a possible transfer of the negative shock from the RCS along the production line. All results were also robust for firm-level NH3-N emissions. This paper provides new and insightful implications for policymaking for environmental protection.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su14063418
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518383-7
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  • 10
    Online Resource
    Online Resource
    Analysis of Carbon Emissions and Emission Reduction from Coal-Fired Power Plants Based on Dual Carbon Targets
    MDPI AG ; 2023
    In:  Sustainability Vol. 15, No. 9 ( 2023-04-28), p. 7369-
    Details
    In: Sustainability, MDPI AG, Vol. 15, No. 9 ( 2023-04-28), p. 7369-
    Abstract: The emission of greenhouse gases poses enormous pressure on current carbon emissions and carbon reduction. Accurate quantification of carbon emissions from coal-fired power plants is of great significance for achieving the dual carbon goal. To enable enterprises to better understand their carbon emissions, this study constructs a carbon emission model and carbon emission data accounting model for coal-fired power plants. Case data calculations and a carbon emission reduction analysis were conducted. The experiment showcases that the carbon sensitivity of the inner side of the boiler under control conditions is higher than that of the operating parameters controlled on the inner side of the steam turbine, with a maximum total value of 16.67 g/MJ; the annual average low calorific value of coal remains between 16,000 kJ/kg; the activity level of coal remains between 30,000 TJ; and the oxidation probability of coal char during combustion fluctuates, with a maximum of 99.8%. In the calculation of coal-fired carbon emissions, the fitting difference between the emissions of generator unit 1 and generator unit 2 is maintained within 2%. Overall, the CO2 emissions of power plants involved in the study are generally high. The model built through this study has well analyzed the carbon emissions of power plants. It is of great significance for the actual carbon emission reduction of coal-fired power plants.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su15097369
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2518383-7
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