In:
International Journal of Cancer, Wiley, Vol. 144, No. 6 ( 2019-03-15), p. 1321-1330
Abstract:
What's new? Although the genotype–phenotype for familial medullary thyroid carcinoma (FMTC) is well studied, only a few low susceptibility risk loci have been identified for familial non‐medullary thyroid carcinoma (FNMTC). Here, the authors screened and identified a novel susceptibility gene, MAP2K5 , as a contributor to FNMTC. The data revealed that MAP2K5 variants A321T or M367 T can activate the MAP2K5–ERK5 pathway, alter downstream gene expression, and subsequently induce thyroid epithelial cell malignant transformation. The study thus highlights the potential application of MAP2K5 for molecular diagnosis as well as better clinical management for deleterious MAP2K5 mutation carriers.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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