In:
ChemBioChem, Wiley, Vol. 25, No. 1 ( 2024-01-02)
Abstract:
We report an efficient and eco‐friendly method for the Vitreoscilla hemoglobin (VHb)‐catalyzed synthesis of benzoxazoles in water at room temperature. tert ‐Butyl hydroperoxide and 2,2,6,6‐tetramethyl‐1‐piperidinyloxy were used as oxidant and radical scavenger, respectively. A total of 27 functionally diverse benzoxazoles were prepared in moderate to high yields (62 %‐94 %) by the annulation reaction of phenols with amines in the presence of VHb in 1 h. Thus, this method is highly viable for practical applications. This work broadens the application of hemoglobin to organic synthesis.
Type of Medium:
Online Resource
ISSN:
1439-4227
,
1439-7633
DOI:
10.1002/cbic.202300609
Language:
English
Publisher:
Wiley
Publication Date:
2024
detail.hit.zdb_id:
2020469-3
SSG:
12
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