In:
PROTEOMICS, Wiley, Vol. 8, No. 20 ( 2008-10), p. 4259-4272
Abstract:
Osteoporosis (OP) is a major public health problem, mainly characterized by low bone mineral density (BMD). Circulating monocytes (CMCs) may serve as progenitors of osteoclasts and produce a wide variety of factors important to bone metabolism. However, the specific action mechanism of CMCs in the pathogenesis of OP is far from clear. We performed a comparative protein expression profiling study of CMCs in Chinese premenopausal females with extremely discordant BMD, identified a total of 38 differentially expressed proteins, and confirmed with Western blotting five proteins: ras suppressor protein1 (RSU1), gelsolin (GSN), manganese‐containing superoxide dismutase (SOD2), glutathione peroxidase 1(GPX1), and prolyl 4‐hydroxylase β subunit (P4HB). These proteins might affect CMCs' trans ‐endothelium, differentiation, and/or downstream osteoclast functions, thus contribute to differential osteoclastogenesis and finally lead to BMD variation. The findings promote our understanding of the role of CMCs in BMD determination, and provide an insight into the pathogenesis of human OP.
Type of Medium:
Online Resource
ISSN:
1615-9853
,
1615-9861
DOI:
10.1002/pmic.200700480
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
2037674-1
SSG:
12
Permalink