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  • 1
    Online Resource
    Online Resource
    The oxytocin receptor rs2254298 polymorphism and alcohol withdrawal symptoms: a gene–environment interaction in mood disorders
    Frontiers Media SA ; 2023
    In:  Frontiers in Psychiatry Vol. 14 ( 2023-7-14)
    Details
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 14 ( 2023-7-14)
    Abstract: Alcohol use disorder (AUD) is a common mental disorder characterized by repeated withdrawal episodes. Negative emotions during withdrawal are the primary factors affecting successful abstinence. Oxytocin is a critical modulator of emotions. OXTR, the oxytocin receptor, may also be a promising candidate for treating alcohol withdrawal symptoms. Previous studies indicated that people with different genotypes of OXTR rs2254298 were reported to suffer from more significant depressive or heightened anxiety symptoms when experiencing early adversity. The present study aims to explore the modulatory role of the polymorphism OXTR rs2254298 on mood disorders during alcohol withdrawal and to help researchers better understand and develop effective relapse prevention and interventions for alcohol use disorders. Methods We recruited 265 adult Chinese Han men with AUD. Anxiety and depressive symptoms were measured using the Self-Rating Anxiety Scale and Self-Rating Depression Scale. Alcohol dependence levels were measured using Michigan Alcoholism Screening Test. Genomic DNA extraction and genotyping from participants’ peripheral blood samples. Result First, a multiple linear regression was used to set the alcohol dependence level, OXTR.rs2254298, interaction terms as the primary predictor variable, and depression or anxiety as an outcome; age and educational years were covariates. There was a significant interaction between OXTR rs2254298 and alcohol dependence level on anxiety ( B  = 0.23, 95% confidence interval [CI]: 0.01–0.45) but not on depression ( B  = −0.06, 95% CI: −0.30 – 0.18). The significance region test showed that alcohol-dependent men who are GG homozygous were more likely to experience anxiety symptoms than subjects with the A allele (A allele: β  = 0.27, p   & lt; 0.001; GG homozygote: β  = 0.50, p   & lt; 0.001). Finally, re-parameterized regression analysis demonstrated that this gene–environment interaction of OXTR rs2254298 and alcohol dependence on anxiety fits the weak differential susceptibility model ( R 2  = 0.17, F (5,259) = 13.46, p   & lt; 0.001). Conclusion This study reveals a gene–environment interactive effect between OXTR rs2254298 and alcohol withdrawal on anxiety but not depression. From the perspective of gene–environment interactions, this interaction fits the differential susceptibility model; OXTR rs2254298 GG homozygote carriers are susceptible to the environment and are likely to experience anxiety symptoms of alcohol withdrawal.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    URL: Article
    DOI: 10.3389/fpsyt.2023.1085429
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2564218-2
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  • 2
    Online Resource
    Online Resource
    Accumulation of endogenous adenosine improves cardiomyocyte metabolism via epigenetic reprogramming in an ischemia-reperfusion model
    Elsevier BV ; 2023
    In:  Redox Biology Vol. 67 ( 2023-11), p. 102884-
    Details
    In: Redox Biology, Elsevier BV, Vol. 67 ( 2023-11), p. 102884-
    Type of Medium: Online Resource
    ISSN: 2213-2317
    URL: Article
    DOI: 10.1016/j.redox.2023.102884
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2701011-9
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  • 3
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    Controlled synthesis of Fe3O4/MnO2 (3 1 0)/ZIF-67 composite with enhanced synergetic effects for the highly selective and efficient adsorption of Cu (II) from simulated copperplating effluents
    Elsevier BV ; 2023
    In:  Environmental Research Vol. 237 ( 2023-11), p. 116940-
    Details
    In: Environmental Research, Elsevier BV, Vol. 237 ( 2023-11), p. 116940-
    Type of Medium: Online Resource
    ISSN: 0013-9351
    URL: Article
    DOI: 10.1016/j.envres.2023.116940
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 205699-9
    detail.hit.zdb_id: 1467489-0
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  • 4
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    Online Resource
    TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death
    Springer Science and Business Media LLC ; 2013
    In:  Nature Communications Vol. 4, No. 1 ( 2013-11-28)
    Details
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 4, No. 1 ( 2013-11-28)
    Abstract: Stroke is a leading global cause of mortality and disability. Less than 5% of patients are able to receive tissue plasminogen activator thrombolysis within the necessary timeframe. Focusing on the process of neuronal apoptosis in the penumbra, which lasts from hours to days after ischaemia, appears to be promising. Here we report that tumour necrosis factor receptor-associated factor 1 (TRAF1) expression is markedly induced in wild-type mice 6 h after stroke onset. Using genetic approaches, we demonstrate that increased neuronal TRAF1 leads to elevated neuronal death and enlarged ischaemic lesions, whereas TRAF1 deficiency is neuroprotective. In addition, TRAF1-mediated neuroapoptosis correlates with the activation of the JNK pro-death pathway and inhibition of the Akt cell survival pathway. Finally, TRAF1 is found to exert pro-apoptotic effects via direct interaction with ASK1. Thus, ASK1 positively and negatively regulates the JNK and Akt signalling pathways, respectively. Targeting the TRAF1/ASK1 pathway may provide feasible therapies for stroke long after onset.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    URL: Article
    DOI: 10.1038/ncomms3852
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2013
    detail.hit.zdb_id: 2553671-0
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  • 5
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    Online Resource
    Relationships of work stress and interpersonal needs with industrial workers’ mental health: a moderated mediation model
    Springer Science and Business Media LLC ; 2023
    In:  BMC Public Health Vol. 23, No. 1 ( 2023-07-12)
    Details
    In: BMC Public Health, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-07-12)
    Abstract: This study explores whether feelings of defeat (i.e., a sense of failed struggle and losing rank; referred to as defeat for simplicity) mediated the effect of work stress on depression/anxiety, the effect of interpersonal needs on depression/anxiety for Chinese industrial workers, and the possible moderating role of social support. Method A cross-sectional study was conducted in Shenzhen, China in 2019, in total, 2023 industrial workers (of 2700 invited; response rate = 75%) completed a self-administered survey consisted of Job Stress Scale, Interpersonal Needs Questionnaire, Defeat Scale, Centre for Epidemiological Studies Depression Scale, Generalized Anxiety Disorder Scale, two face-valid questions for social support, as well as sociodemographic information. Moderated mediation model was tested and loop plots were applied to probe into the conditional effects of work and interpersonal stress on depression and anxiety symptoms. Result Both the direct and indirect effect of work stress on depression and anxiety through defeat were significant (Work stress→ Depression: B  = 0.035, p   〈  .001, Work stress→ Defeat→ Depression: B  = 0.034, p   〈  .001; Work stress→ Anxiety: B  = 0.038, p   〈  .001, Work stress→ Defeat→ Anxiety: B  = 0.045, p   〈  .001). Meanwhile, defeat mediated the relationship of interpersonal needs with depression partially and the relationship of interpersonal needs with anxiety totally (Interpersonal needs→ Anxiety: B = 0.133, p  〈  .001, Interpersonal needs→ Defeat→ Anxiety: B  = 0.010, p  = .537). Social support moderated the indirect path between interpersonal needs and depression/anxiety and buffered the effect. Conclusion The mediating role of defeat and the moderator role of social support in the relationship between stress and depression/anxiety were confirmed in industrial workers. Workers who reported more work and interpersonal stress would report more defeat feelings, and then exhibited more depression and anxiety symptoms; this mediation effect was stronger for those who had lower social support, respectively.
    Type of Medium: Online Resource
    ISSN: 1471-2458
    URL: Article
    DOI: 10.1186/s12889-023-16002-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2041338-5
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  • 6
    Online Resource
    Online Resource
    DataSheet_1.pdf
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-11-29)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-11-29)
    Abstract: In the first-line treatment of advanced non-small cell lung cancer (NSCLC), for those patients with negative PD-L1 expression, which treatment strategy has the better efficacy and safety between chemotherapy combined with antiangiogenic and with immune checkpoint inhibitors (ICIs) is still unclear due to the absence of head-to-head clinical trials. This study aims to answer the question by performing a systematic review and network meta-analysis (NMA). Methods Electronic databases (PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov) were systematically searched accordingly to extract eligible studies from inception to October 2022, as well as the abstracts from the most recent main oncology congresses (American Association for Cancer Research (AACR), American Society of Clinical Oncology (ASCO), World Conference on Lung Cancer (WCLC), and European Society for Medical Oncology (ESMO)). Overall survival (OS), progression-free survival (PFS), and adverse events (AEs) of grades 3 to 5 were independently extracted and collected by two reviewers based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. We used Cochrane’s risk of bias tool for randomized controlled trials through RevMan 5.3 to ascertain the quality of the included studies. NMA with a Bayesian random-effects model was performed by R (version 4.0.4). Results According to the ranking list from OS-NMA, pembrolizumab combined with chemotherapy has the most effective ranking first (surface under the cumulative ranking (SUCRA) = 0.809844) (pooled HR = 0.65 [0.51–0.83]). On PFS, the triple combination of nivolumab/bevacizumab/chemotherapy ranks first (NMA estimate: HR = 0.35 [0.28–0.43] ). On safety, in combination with chemotherapy, sintilimab has minimal toxicity, followed by pembrolizumab+chemo. Conclusions In advanced NSCLC patients with negative PD-L1 expression, pembrolizumab+chemo ranks first in the efficacy of OS and does not apparently increase the incidence of any grade ≥ 3 AE as compared with chemo alone. On PFS, pembrolizumab also has advantages, but for patients with squamous cell carcinoma, camrelizumab+chemo seems to be a better choice. Systematic review registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42021231441.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2022.1001503
    DOI: 10.3389/fonc.2022.1001503.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 7
    Online Resource
    Online Resource
    Green Synthesis of Hierarchically Porous Alginate/ZIF‐8 Composite Beads for Water Treatment
    Wiley ; 2023
    In:  ChemNanoMat Vol. 9, No. 3 ( 2023-03)
    Details
    In: ChemNanoMat, Wiley, Vol. 9, No. 3 ( 2023-03)
    Abstract: The immobilization of powdery metal‐organic‐frameworks (MOFs) into porous matrix has risen to be a promising approach for their practical applications. This work presents the green synthesis of porous alginate/ZIF‐8 composite beads through the in situ growth of ZIF‐8 in alginate hydrogel beads crosslinked by Zn 2+ and subsequent freeze‐drying process, during which only water is used as reaction solvent. The macro‐ and meso‐pores in alginate matrix and micro‐pores in immobilized ZIF‐8 endow the porous composite beads with hierarchically porous structure, which benefits their adsorption properties. Methylene blue (MB) is selected as probe molecule to assess the adsorption performance of the porous composite beads toward water contaminants. It is found that the growth time of ZIF‐8 has a significant influence on the adsorption performance, and the calculated maximum adsorption capacity of ZIF‐8@Alg30 for MB reaches 628.93 mg g −1 at 298 K. Additionally, the adsorption process fits well with the pseudo‐second‐order kinetic model and Langmuir isotherm model, and the adsorption process is found to be spontaneous, endothermic and irreversible based on thermodynamic studies.
    Type of Medium: Online Resource
    ISSN: 2199-692X , 2199-692X
    URL: Issue
    URL: Article
    DOI: 10.1002/cnma.v9.3
    DOI: 10.1002/cnma.202200397
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2827071-X
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  • 8
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    Online Resource
    Modeling and Self-Excitation Analysis of Split Cascade Brushless Excitation Pulsed Alternator System
    Institute of Electrical and Electronics Engineers (IEEE) ; 2024
    In:  IEEE Transactions on Plasma Science Vol. 52, No. 3 ( 2024-3), p. 1012-1024
    Details
    In: IEEE Transactions on Plasma Science, Institute of Electrical and Electronics Engineers (IEEE), Vol. 52, No. 3 ( 2024-3), p. 1012-1024
    Type of Medium: Online Resource
    ISSN: 0093-3813 , 1939-9375
    URL: Article
    DOI: 10.1109/TPS.2024.3377646
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2024
    detail.hit.zdb_id: 2025402-7
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  • 9
    Online Resource
    Online Resource
    Health effect of multiple air pollutant mixture on sarcopenia among middle-aged and older adults in China
    Elsevier BV ; 2024
    In:  Ecotoxicology and Environmental Safety Vol. 281 ( 2024-08), p. 116634-
    Details
    In: Ecotoxicology and Environmental Safety, Elsevier BV, Vol. 281 ( 2024-08), p. 116634-
    Type of Medium: Online Resource
    ISSN: 0147-6513
    URL: Article
    DOI: 10.1016/j.ecoenv.2024.116634
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 1466969-9
    SSG: 24,1
    SSG: 12
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  • 10
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    Online Resource
    Interferon Regulatory Factor 7 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy
    Ovid Technologies (Wolters Kluwer Health) ; 2014
    In:  Hypertension Vol. 63, No. 4 ( 2014-04), p. 713-722
    Details
    In: Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 63, No. 4 ( 2014-04), p. 713-722
    Abstract: Cardiac hypertrophy is a complex pathological process that involves multiple factors including inflammation and apoptosis. Interferon regulatory factor 7 (IRF7) is a multifunctional regulator that participates in immune regulation, cell differentiation, apoptosis, and oncogenesis. However, the role of IRF7 in cardiac hypertrophy remains unclear. We performed aortic banding in cardiac-specific IRF7 transgenic mice, IRF7 knockout mice, and the wild-type littermates of these mice. Our results demonstrated that IRF7 was downregulated in aortic banding–induced animal hearts and cardiomyocytes that had been treated with angiotensin II or phenylephrine for 48 hours. Accordingly, heart-specific overexpression of IRF7 significantly attenuated pressure overload–induced cardiac hypertrophy, fibrosis, and dysfunction, whereas loss of IRF7 led to opposite effects. Moreover, IRF7 protected against angiotensin II–induced cardiomyocyte hypertrophy in vitro. Mechanistically, we identified that IRF7-dependent cardioprotection was mediated through IRF7 binding to inhibitor of κB kinase-β, and subsequent nuclear factor-κB inactivation. In fact, blocking nuclear factor-κB signaling with cardiac-specific inhibitors of κBα S32A/S36A super-repressor transgene counteracted the adverse effect of IRF7 deficiency. Conversely, activation of nuclear factor-κB signaling via a cardiac-specific conditional inhibitor of κB kinase-β S177E/S181E (constitutively active) transgene negated the antihypertrophic effect of IRF7 overexpression. Our data demonstrate that IRF7 acts as a novel negative regulator of pathological cardiac hypertrophy by inhibiting nuclear factor-κB signaling and may constitute a potential therapeutic target for pathological cardiac hypertrophy.
    Type of Medium: Online Resource
    ISSN: 0194-911X , 1524-4563
    URL: Article
    DOI: 10.1161/HYPERTENSIONAHA.113.02653
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2014
    detail.hit.zdb_id: 2094210-2
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