In:
Angewandte Chemie, Wiley, Vol. 133, No. 50 ( 2021-12-06), p. 26541-26545
Abstract:
Inflammation usually results in high‐level reactive oxygen species (ROS) and reactive nitrogen species (RNS) not only in acidic tissue but also in alkaline tissue. However, noninvasively in vivo monitoring reactive species specifically within alkaline tissue remains a huge challenge. Here we introduce a dual activatable fluorescent probe PN910 located in the second near‐infrared window (NIR‐II, 900–1700 nm), which shows high selectivity toward H 2 O 2 and OONO − at pH beyond 7.4. Then we verified that PN910 could be used for the real‐time, specific and accurate monitoring of cystitis and colitis for living animals. This report presents a unique approach to the development of dual activatable probe for in vivo biosensing.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v133.50
DOI:
10.1002/ange.202109728
Language:
English
Publisher:
Wiley
Publication Date:
2021
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505868-5
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506609-8
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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