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  • 1
    Online Resource
    Online Resource
    Synthetic Peptides outside the Spike Protein Heptad Repeat Regions as Potent Inhibitors of Sars-Associated Coronavirus
    SAGE Publications ; 2005
    In:  Antiviral Therapy Vol. 10, No. 3 ( 2005-04), p. 393-403
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 10, No. 3 ( 2005-04), p. 393-403
    Abstract: A novel severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) has been identified as the aetiological agent of SARS. We previously isolated and characterized SARS-CoV and SARS-CoV-like viruses from human and animals, respectively, suggesting that SARS could be transmitted from wild/farmed animals to humans. Comparison of the viral genomes indicated that sequence variation between animal and human isolates existed mainly in the spike (S) gene. We hypothesized that these variations may underlie a change of binding specificity of the S protein to the host cells, permitting viral transmission from animals to humans. Here we report that four 20-mer synthetic peptides (S protein fragments), designed to span these sequence variation otspots, exhibited significant antiviral activities in a cell line. SARS-CoV infectivity was reduced over 10 000-fold through pre-incubation with two of these peptides, while it was completely inhibited in the presence of three peptides. Molecular modelling of the SARS-CoV peplomer suggests that three of these antiviral peptides map to the interfaces between the three monomers of the trimeric peplomer rather than the heptad repeat region from which short peptides are known to inhibit viral entry. Our results revealed novel regions in the spike protein that can be targeted to inhibit viral infection. The peptides identified in this study could be further developed into antiviral drugs.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965350501000301
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 2118396-X
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  • 2
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    Online Resource
    The value of CT-based radiomics in early assessment of chemotherapeutic effect in patients with advanced lung adenocarcinoma: a preliminary study
    SAGE Publications ; 2023
    In:  Acta Radiologica Vol. 64, No. 2 ( 2023-02), p. 524-532
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 64, No. 2 ( 2023-02), p. 524-532
    Abstract: Computed tomography (CT) is the preferred method for evaluating the therapeutic effect of lung cancer. Radiomics parameters can provide a lot of supplementary information for clinical diagnosis and treatment. Purpose To investigate the value of radiomics features of CT imaging to predict and evaluate the early efficacy of chemotherapy in patients with advanced lung adenocarcinoma. Material and Methods A total of 101 patients with advanced lung adenocarcinoma were enrolled. Patients were classified into a response group and non-response group according to RECIST 1.1 standard. All patients underwent chest CT examination before and after two cycles of chemotherapy. A total of 293 radiomics features were calculated. The features between response group and non-response group were compared before and after chemotherapy. The diagnostic efficacy was evaluated using the receiver operating characteristic curve. Results The six pre-chemotherapy radiomics features were selected, with area under the curve (AUC), sensitivity, and specificity at 0.720, 68.3%, and 69.0% in the training group and 0.573, 50.0%, and 76.9% in the test group, respectively. The eleven post-chemotherapy radiomics features were selected, with AUC, sensitivity, specificity at 0.789, 75.6%, and 75.9% in the training group and 0.718, 61.1%, and 76.9% in the test group, respectively. The prognostic value of △f8, △f16, %f8, and %f16 were higher than the other features with AUCs of 0.787, 0.837, 0.763, and 0.877, respectively. Conclusion Radiomics is expected to provide more valuable information for evaluating the chemotherapy efficacy of lung adenocarcinoma.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/02841851221078290
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024579-8
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  • 3
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    Online Resource
    Overexpression of annexin A5 might guide the gemtuzumab ozogamicin treatment choice in patients with pediatric acute myeloid leukemia
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Medical Oncology Vol. 12 ( 2020-01), p. 175883592092763-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592092763-
    Abstract: Acute myeloid leukemia (AML) is a common hematological malignancy. Gemtuzumab ozogamicin (GO), a humanized anti-CD33 antibody conjugated with the potent anti-tumor antibiotic calicheamicin, represents a promising targeted therapy for AML. Annexin A5 (ANXA5) is a proposed marker for the clinical prognosis of AML to guide treatment choice. Methods: In total, 253 patients with pediatric AML were enrolled and divided into two treatment groups: conventional chemotherapy alone and conventional chemotherapy in combination with GO. Univariate, multivariate, and Kaplan–Meier survival analyses were conducted to assess risk factors and clinical outcomes, and to estimate hazard ratios (HRs) and their 95% confidence interval. The level of statistical significance was set at p  〈  0.05. Results: In the GO treatment group, high ANXA5 expression was considered a favorable prognostic factor for overall survival (OS) and event-free survival (EFS). Multivariate analysis showed that high ANXA5 expression was an independent favorable factor for OS (HR = 0.629, p = 0.084) and EFS (HR = 0.544, p = 0.024) distinct from the curative effect of GO treatment. When all patients were again divided into two groups, this time based on the median expression of ANXA5, patients undergoing chemotherapy combined with GO had significantly better OS ( p = 0.0012) and EFS ( p = 0.0003) in the ANXA5 high-expression group. Gene set enrichment analysis identified a relevant series of pathways associated with glutathione metabolism, leukocyte transendothelial migration, and hematopoietic cell lineage. Conclusion: The expression level of ANXA5 can help optimize the treatment regimen for individual patients, and patients with overexpression of ANXA5 may circumvent poor outcomes from chemotherapy combined with GO.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835920927635
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2503443-1
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  • 4
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    Online Resource
    Preparation and characterization of poly(ether sulfone)/fluorinated silica organic–inorganic composite membrane for sulfur dioxide desulfurization
    SAGE Publications ; 2019
    In:  High Performance Polymers Vol. 31, No. 1 ( 2019-02), p. 72-85
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 31, No. 1 ( 2019-02), p. 72-85
    Abstract: The highly hydrophobic poly(ether sulfone)/fluorinated silica (PES/fSiO 2 ) organic–inorganic composite membrane for sulfur dioxide (SO 2 ) desulfurization was prepared by incorporating the fSiO 2 particles on the PES membrane via sol–gel process and fluorination. The formation of PES/fSiO 2 organic–inorganic composite membrane was examined by attenuated total reflectance Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, thermal gravimetric analysis, field-emission scanning electron microscopy, and water contact angle. The experimental results showed that the fSiO 2 inorganic layer was tightly bonded to the PES membrane surface through silane chemical reactions. The incorporation of the fSiO 2 inorganic layer on the PES membrane surface increases the surface roughness and reduces the surface free energy because of the hydrophobic dodecafluoroheptyl-propyl-trimethoxysilane. The hydrophobicity of the PES/fSiO 2 composite membrane was dramatically enhanced from 78.0° of PES membrane to 128.2° of PES/fSiO 2 membrane. Compared with PES membrane, the desulfurization performance of PES/fSiO 2 membrane was investigated. PES/fSiO 2 organic–inorganic composite membrane indicated a reasonably stable SO 2 absorption flux of 7.69E-4 mol/m 2 s during the 240-min-long time operation.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/0954008317752072
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 1483713-4
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  • 5
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    Online Resource
    A Risk of Venous Thromboembolism Algorithm as a Predictor of Venous Thromboembolism in Patients with Colorectal Cancer
    SAGE Publications ; 2021
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 27 ( 2021-01), p. 107602962110649-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 27 ( 2021-01), p. 107602962110649-
    Abstract: Cancer patients experience an increased risk of venous thromboembolism (VTE). In this study, we investigated a risk of venous thromboembolism algorithm (RVTA) in patients with colorectal cancer and evaluated its ability to predict the prognosis of colorectal cancer. We retrospectively analyzed clinical data from 345 patients with colorectal cancer from January 2015 to December 2018 at the Shanghai Cancer Center to develop the RVTA. Additionally, the 345 patients were followed until December 2020 for prognostic analysis. The RVTA included the following variables: (a) platelet count, (b) blood transfusion history, (c) metastasis, (d) multiple chemotherapy regimens, and (e) the D-dimer level. Good predictive efficiency was observed for the RVTA (AUC was 0.825; 95% CI was 0.721 to 0.930). The median progression-free survival (PFS) of patients who had a score less than 4 (0-3), defined as the low-risk group, was significantly longer than that of the high-risk group, which included patients who had a score greater than 4 (4-8) (26 vs ten months, P  〈  .001). The RVTA was a valuable predictor for VTE risk and had prognostic value in colorectal cancer.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/10760296211064900
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2230591-9
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  • 6
    Online Resource
    Online Resource
    Progesterone activates the cyclic AMP-protein kinase A signalling pathway by upregulating ABHD2 in fertile men
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 3 ( 2021-03), p. 030006052199952-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 3 ( 2021-03), p. 030006052199952-
    Abstract: This was a prospective study to investigate whether progesterone affects sperm activity by regulating the cyclic AMP-protein kinase A (cAMP-PKA) signalling pathway via α/β hydrolase domain-containing protein 2 (ABHD2). Methods Spermatozoa were collected from healthy and infertile men (with oligoasthenospermia or abnormal acrosome; n = 30/group). The expression of and mutations in ABHD2 were detected by quantitative PCR, western blot, and gene sequencing. The expression of ABHD2 in the presence of progesterone was detected in all groups, and cAMP and PKA levels were detected by ELISA in fertile men after treatment with ABHD2 antibody and PKA inhibitor H-89, respectively. Results Expression of ABHD2 mRNA and protein were reduced in spermatozoa from infertile compared with fertile men. Four gene mutation sites were detected in spermatozoa from the infertile groups. Progesterone increased mRNA and protein levels of ABHD2 in healthy spermatozoa but not in spermatozoa from infertile men. The levels of cAMP and PKA were increased by progesterone in healthy spermatozoa, and the progesterone-increased cAMP and PKA were decreased by ABHD2 antibody and H-89, respectively. Conclusion Progesterone regulates the ABHD2-mediated cAMP-PKA signalling pathway in healthy spermatozoa, which provides a new target for clinical diagnosis and treatment of infertility.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060521999527
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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  • 7
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    A new shock-wave test apparatus for liquid CO 2 blasting and measurement analysis
    SAGE Publications ; 2019
    In:  Measurement and Control Vol. 52, No. 5-6 ( 2019-06), p. 399-408
    Details
    In: Measurement and Control, SAGE Publications, Vol. 52, No. 5-6 ( 2019-06), p. 399-408
    Abstract: Liquid CO 2 blasting of coal or rock body technology is widely used for improving permeability, pressure relief, cutting proof, and roadway development. Due to the lack of proper apparatus for blasting measurement, the determination of blasting parameters is often not under scientific basis. A newly designed experimental apparatus is developed to monitor shock-wave pressure of liquid CO 2 blasting. The apparatus mainly consists of testing tube and base bracket. The testing tube is fixed on the base bracket by fixed ring. The base bracket is fixed to the ground by expansion bolts to ensure the stability of the apparatus and personnel safety during blasting. Three testing tubes with inner diameter of 48, 68, and 82 mm are designed and manufactured to simulate different sizes of boreholes. Monitoring holes are drilled on the testing tube to monitor blasting shock-wave pressure in real time. The maximum pressure of the shock-wave and its acting duration can be obtained. Experimental results also revealed that the normal direction of the gas outlet is the effective shock-wave acting area where the maximum pressure reaches more than 160 MPa. The shock-wave pressure is in non-linear relationship with the distance from gas outlet. By comparison of the blasting tube sealed to unsealed condition, it is found that sealing can be effected by increment in shock-wave pressure of about 43.3%. The research results provide a basis and reference work for determination and optimization of liquid CO 2 blasting parameters.
    Type of Medium: Online Resource
    ISSN: 0020-2940
    URL: Article
    DOI: 10.1177/0020294019838581
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2712343-1
    SSG: 3,2
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  • 8
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    Online Resource
    The State Owes Us: Social Exclusion and Collective Actions of China’s Bereaved Parents
    SAGE Publications ; 2021
    In:  Modern China Vol. 47, No. 6 ( 2021-11), p. 740-764
    Details
    In: Modern China, SAGE Publications, Vol. 47, No. 6 ( 2021-11), p. 740-764
    Abstract: China’s one-child policy has come to an end, but its ramifications continue. This article explores the issue of bereaved parents who lost their only child as an unintended consequence of the one-child policy and provides a social and political analysis of their suffering and resistance. Chinese social institutions and cultural norms traditionally discriminate against bereaved parents, excluding them from social support and social relations. As a result, bereaved parents often cut ties with their extended families, networks, and other social relations; they are stigmatized, marginalized, and isolated. However, through the internet and social media, these parents have begun forging new social relations and associations among themselves. They mobilize collective protests fueled by shared grief and the moral appeal of their patriotic sacrifice for the state, demanding official government recognition and compensation for their losses. This article treats bereavement as a subject of analysis and shows how state power shapes or even damages people’s everyday lives in a specific family-centered cultural context.
    Type of Medium: Online Resource
    ISSN: 0097-7004 , 1552-6836
    URL: Article
    DOI: 10.1177/0097700420948801
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2028975-3
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  • 9
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    A Noninvasive Body Setup Method for Radiotherapy by Using a Multimodal Image Fusion Technique
    SAGE Publications ; 2017
    In:  Technology in Cancer Research & Treatment Vol. 16, No. 6 ( 2017-12), p. 1187-1193
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 16, No. 6 ( 2017-12), p. 1187-1193
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533034617740302
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 10
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    A New Triterpenoid from the Aerial Parts of Agrimonia pilosa
    SAGE Publications ; 2015
    In:  Natural Product Communications Vol. 10, No. 12 ( 2015-12), p. 1934578X1501001-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 10, No. 12 ( 2015-12), p. 1934578X1501001-
    Abstract: (1 S,3 R,17 R,18 R,19 R,20 R,22 R)-1,3,19,22-tetrahydroxy-28-norurs-12-en-2-one (1), along with 5 known triterpenoids (2–6), were isolated from the aerial parts of Agrimonia pilosa Ledeb. Their structures were established based on extensive spectroscopic and MS analysis. The absolute configuration of compound 1 was deduced by circular dichroism (CD). Compound 1 was the first example of a 28-norursene backbone isolated from the genus Agrimonia. Compounds 2–6 were tested for anti-inflammatory activities against RAW 264.7 macrophages. A plausible biosynthetic pathway for compound 1 in A. pilosa was also proposed.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1501001207
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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