In:
Dalton Transactions, Royal Society of Chemistry (RSC), Vol. 51, No. 10 ( 2022), p. 4068-4078
Abstract:
In this study, 13 transition metal complexes, namely, [Cu(L 1 H)(H 2 O) 2 ]·(H 2 O)·NO 3 (1), [Cu(L n H 2 ) 2 ]·(NO 3 )·(H 2 O) 2 (2, n = 2; 3, n = 3; 4, n = 4; 5, n = 5), [Co(L n H) 2 ] 2 ·(H 2 O) 0.5 (6, n = 2; 7, n = 3; 8, n = 4; 9, n = 5), [Cu(L 6 H) 0.5 (L 10 H) 0.5 (phen)]·(CH 3 OH) 0.25 (10), [Cu(L 11 H) (phen)] 4 ·(H 2 O) 9 (11), [Cu(L 8 H) 0.27 (L 12 H) 0.73 (phen)] 4 ·(H 2 O) 5.5 (CH 3 OH) (12), and [Cu(L 9 H) (phen)] 3 ·(H 2 O) 7 ·(CH 3 OH) (13), were synthesized using Schiff base ligands and characterized by elemental analysis (EA), infrared spectroscopy (IR), and single-crystal X-ray diffraction (SC-XRD). Compared with complexes 1–9, complexes 10–13 displayed stronger cytotoxic activities against the tested A549/DDP cancer cells (IC 50 = 0.97–3.31 μM), with differences greater than one order of magnitude. Moreover, complexes 11 and 13 could induce apoptosis and autophagy in A549/DDP cells via the mitochondrial dysfunction pathway that affects the regulation of autophagy- and mitochondrial-related proteins. Importantly, the results indicate that the two novel salicylaldehyde Schiff base analogs, 11 and 13, exhibited pronounced and selective activity against A549/DDP xenografts in vivo .
Type of Medium:
Online Resource
ISSN:
1477-9226
,
1477-9234
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
detail.hit.zdb_id:
1472887-4
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