In:
Journal of Industrial Microbiology and Biotechnology, Oxford University Press (OUP), Vol. 42, No. 4 ( 2015-04-01), p. 577-583
Abstract:
Although it is generally known that cofactors play a major role in the production of different fermentation products, their role has not been thoroughly and systematically studied. To understand the impact of cofactors on physiological functions, a systematic approach was applied, which involved redox state analysis, energy charge analysis, and metabolite analysis. Using uridine 5′-monophosphate metabolism in Saccharomyces cerevisiae as a model, we demonstrated that regulation of intracellular the ratio of NADPH to NADP+ not only redistributed the carbon flux between the glycolytic and pentose phosphate pathways, but also regulated the redox state of NAD(H), resulting in a significant change of ATP, and a significantly altered spectrum of metabolic products.
Type of Medium:
Online Resource
ISSN:
1476-5535
,
1367-5435
DOI:
10.1007/s10295-014-1536-y
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2015
detail.hit.zdb_id:
1482484-X
SSG:
12
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