In:
Experimental Diabetes Research, Hindawi Limited, Vol. 2012 ( 2012), p. 1-6
Abstract:
LYR motif containing 1 ( LYRM1 ) is a novel gene that is abundantly expressed in the adipose tissue of obese subjects and is involved in insulin resistance. In this study, free fatty acids (FFAs) and tumor necrosis factor- α (TNF- α ) are shown to upregulate LYRM1 mRNA expression in 3T3-L1 adipocytes. Conversely, resistin and rosiglitazone exert an inhibitory effect on LYRM1 mRNA expression. These results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity. LYRM1 may be an important mediator in the development of obesity-related insulin resistance.
Type of Medium:
Online Resource
ISSN:
1687-5214
,
1687-5303
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2012
detail.hit.zdb_id:
2465179-5
detail.hit.zdb_id:
2711897-6
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