In:
Angewandte Chemie, Wiley, Vol. 133, No. 27 ( 2021-06-25), p. 15133-15139
Abstract:
Singlet oxygen ( 1 O 2 ) has a potent anticancer effect, but photosensitized generation of 1 O 2 is inhibited by tumor hypoxia and limited light penetration depth. Despite the potential of chemodynamic therapy (CDT) to circumvent these issues by exploration of 1 O 2 ‐producing catalysts, engineering efficient CDT agents is still a formidable challenge since most catalysts require specific pH to function and become inactivated upon chelation by glutathione (GSH). Herein, we present a catalytic microenvironment‐tailored nanoreactor (CMTN), constructed by encapsulating MoO 4 2− catalyst and alkaline sodium carbonate within liposomes, which offers a favorable pH condition for MoO 4 2− ‐catalyzed generation of 1 O 2 from H 2 O 2 and protects MoO 4 2− from GSH chelation owing to the impermeability of liposomal lipid membrane to ions and GSH. H 2 O 2 and 1 O 2 can freely cross the liposomal membrane, allowing CMTN with a built‐in NIR‐II ratiometric fluorescent 1 O 2 sensor to achieve monitored tumor CDT.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v133.27
DOI:
10.1002/ange.202102097
Language:
English
Publisher:
Wiley
Publication Date:
2021
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