In:
Journal of Biomedical Nanotechnology, American Scientific Publishers, Vol. 17, No. 3 ( 2021-03-01), p. 357-368
Abstract:
Ferulic acid (FA), an active component extracted from Chinese medicine, shows excellent anti-inflammatory properties and favorable safety in various animal models. However, the application of FA as an anti-inflammatory drug is hindered by its instability and short half-life in vivo . In this paper, we synthesize PEGylated diphenylalanine nanoparticles by using glutaraldehyde (GTA) as a cross-linker of diphenylalanine NH 2 -Phe–Phe-COOH and poly(ethylene glycol) methyl ether amine (PEG 5k -NH 2 ). The PEGylated Phe–Phe nanoparticles
are used to deliver FA for the treatment of Rheumatoid arthritis (RA). We find that the FA-loaded PEGylated Phe–Phe nanoparticles are biocompatible and inhibit the production of reactive oxygen species (ROS) from cells effectively. After being intravenously administrated in vivo , the FA-loaded PEGylated Phe–Phe nanoparticles show prolonged circulation time and accumulate in arthritic joints. More importantly, we show that the pre-arthritis treatment with the FA-loaded PEGylated Phe–Phe nanoparticles can significantly block the progression of RA.
Type of Medium:
Online Resource
ISSN:
1550-7033
DOI:
10.1166/jbn.2021.3022
Language:
English
Publisher:
American Scientific Publishers
Publication Date:
2021
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