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  • 1
    Online Resource
    Online Resource
    Inhibitory Activities of Extracts from Chinese Medicinal Herbs on α-Amylase, α-Glucosidase,and Pancreatic Lipase
    SAGE Publications ; 2023
    In:  Pharmacognosy Magazine Vol. 19, No. 3 ( 2023-09), p. 530-538
    Details
    In: Pharmacognosy Magazine, SAGE Publications, Vol. 19, No. 3 ( 2023-09), p. 530-538
    Abstract: Metabolic syndrome is an assortment of conditions that often happens together and upsurge your risk of diabetes, stroke, and heart disease. One strategy for the prophylaxis and treatment of diabetes and obesity is to inhibit the enzymes activities, which include α-glucosidase, α-amylase, and pancreatic lipase. Objectives To screen the effect of 16 Chinese medicinal herbs on inhibition of α-glucosidase, α-amylase, and pancreatic lipase. Materials and Methods The water extraction of 16 traditional Chinese herbal medicines was used to estimate activity in vitro from different families against α-glucosidase, α-amylase, and pancreatic lipase by using spectrophotometry with p-nitrophenyl-α-D-glucopyranoside (PNPG), starch derivatives, and 4-methylumbelliferone (4-MUO), respectively, as a substrate. Results The results showed that the water extraction yield of the 16 rhizomes ranged from 0.2% to 4.0%. Among the tested extracts, the extract from Gastrodia elata exhibited the strongest effect on α-amylase (The half-maximal inhibitory concentration (IC 50 )) = 4.10 mg/mL). The extracts from Pinellia ternate and Arisaema heterophyllum exhibited noteworthy effects on α-glucosidase (IC 50 = 29.21 and 41.13 µg/mL, respectively), and Corydalis turtschaninovii possessed the highest effect on pancreatic lipase (IC 50 = 4.11 µg/mL) and a stronger effect than orlistat (IC 50 = 4.52 µg/mL). Conclusion This study provides a basis for screenings and in-depth studies of anti-obesity and anti-diabetes drugs. Further isolation, identification, and characterization of active compounds should be carried out in the future.
    Type of Medium: Online Resource
    ISSN: 0973-1296 , 0976-4062
    URL: Article
    DOI: 10.1177/09731296231168739
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2274976-7
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  • 2
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    A transparent and intumescent phosphaphenanthrene/phenylpyrazole-containing epoxy resin system and its flame retardancy
    SAGE Publications ; 2021
    In:  High Performance Polymers Vol. 33, No. 7 ( 2021-09), p. 760-773
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 33, No. 7 ( 2021-09), p. 760-773
    Abstract: A novel intumescent flame retardant, PPMD, was designed from phosphaphenanthrene and nitrogen heterocycles through the two-step gut reactions of 1,4-phthalaldehyde and 3-methyl-1-phe-nylpyrazol-5-ylamine. After determination of its structure by nuclear magnetic resonance and Fourier-transform infrared analyses, PPMD was added to an epoxy resin (EP) to facilitate a curing process. Thus, EP/PPMD samples with excellent transparency and flame retardancy were acquired. For example, the EP sample satisfied the UL-94 V-0 standard and achieved a limiting oxygen index value of 30.5% because of the incorporation of 5 wt% PPMD. The cone calorimeter test of the EP/5% PPMD sample revealed that its total smoke production (TSP) and total heat release (THR) values of EP/5% PPMD was only 22.5% and 56.4% of the control group, respectively. Moreover, the average effective heat of combustion (av-EHC) value of EP/5% PPMD was reduced by 34.1%, indicating that PPMD possessed high flame-inhibition activity and smoke suppression efficiency. The flame-retardant mechanisms of PPMD were also investigated in gas phase by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) and in condensed phase by XPS and IR.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/0954008321992412
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 1483713-4
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  • 3
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    Effects of the turbulence model and the spray model on predictions of the n -heptane jet fuel–air mixing and the ignition characteristics with a reduced chemistry mechanism
    SAGE Publications ; 2017
    In:  Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering Vol. 231, No. 14 ( 2017-12), p. 1877-1888
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, SAGE Publications, Vol. 231, No. 14 ( 2017-12), p. 1877-1888
    Abstract: Reynolds-averaged Navier–Stokes simulations with an improved spray model and a realistic chemistry mechanism are performed for turbulent spray flames under diesel-like conditions in a constant-volume chamber. Comprehensive numerical analyses including two turbulence models (the renormalisation group k– ε model and the standard two-equation k– ε model) with different model coefficients are made. The distribution of the fuel mixture fractions is a very important factor affecting the combustion process. In this study, we also use the entrainment gas-jet model, modifications of the the spray model coefficient and two turbulence models to investigate extensively the influence of the gas-jet theory model on the fuel–air mixture process. First, a non-reacting case is validated by comparing the liquid-phase penetration and the vapour-phase penetration and also the mixture fractions at different axis positions. Second, approriate methods are confirmed according to accurate mixture fraction distributions to validate the combustion process. Because of the large number of species and reactions, the calculation of chemically reacting flows is unaffordable, particularly for three-dimensional simulations. Hence, the dynamic adaptive chemistry method for efficient chemistry calculations is extended in this work to reduce the computational cost of the spray combustion process when a reduced chemistry mechanism is used. The results show that, in the evaporation case, the gas-jet theory model can be used to obtain a relatively accurate fuel vapour penetration length with different influential factors and that improved numerical methods can effectively reduce the mesh dependence for the spray evaporation process. It is demonstrated that the Schmidt number Sc and the turbulence models significantly influence the mixture fraction distribution. Very good agreement with available experimental data is found concerning the ignition delay time and the flame lift-off length for different oxygen concentrations owing to the accurate fuel mixture fraction.
    Type of Medium: Online Resource
    ISSN: 0954-4070 , 2041-2991
    URL: Article
    DOI: 10.1177/0954407016687478
    RVK:
    ZO 4200
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2032754-7
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  • 4
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    Experimental investigation on reactivity-controlled compression ignition (RCCI) combustion characteristic of n-heptane/ammonia based on an optical engine
    SAGE Publications ; 2023
    In:  International Journal of Engine Research Vol. 24, No. 6 ( 2023-06), p. 2478-2488
    Details
    In: International Journal of Engine Research, SAGE Publications, Vol. 24, No. 6 ( 2023-06), p. 2478-2488
    Abstract: Ammonia as a carbon-free fuel used in IC engines always suffers from large cyclic variations and high NOx emissions. Ammonia blending with high-reactivity fuels is recognized as an effective attempt to overcome these shortcomings. In this work, for the first time, the combustion and emission characteristics of n-heptane/ammonia were investigated under reactivity-controlled compression ignition (RCCI) conditions in an optical engine. An intake adapter was introduced to modify turbulent flow motion and n-heptane was directly injected to regulate mixture reactivity based on energy ratios. Particle image velocimetry (PIV) was employed for in-cylinder flow measurement, high-speed photography and instantaneous pressure acquisition were used for combustion evolutions, and Fourier transform infrared (FTIR) spectroscopy was adopted for NOx and NH 3 emissions. The results show both mixture reactivity and turbulence have significant impacts on ammonia combustion. Specifically, n-heptane addition manifesting mixture reactivity dominates combustion processes at early-injection conditions, while the turbulence with increasing intensity becomes significant at late-injection conditions. Visualization images show that the initiation of initial flame kernels is controlled by the local distribution of n-heptane fraction, and that high n-heptane fraction at early injection or low n-heptane fraction at late injection conditions tends to induce homogeneous combustion. Flame stretch analysis confirms the promotion of mixture reactivity and turbulence motion on turbulent flame propagation and identifies that a high n-heptane fraction with swirl-tumble motion exhibits lower flame stretch sensitivity, especially for late-injection scenarios. Besides, low mixture reactivity with early injection and high mixture reactivity with late injection strategies can achieve high-efficiency combustion. However, when considering NO X /NH 3 emissions, a high n-heptane fraction at late injection with swirl-tumble motion has the most potential to achieve the compromise between thermal efficiency and emissions. The present work demonstrates that with optimized fuel injection and flow arrangement, ammonia blending with high-reactivity fuels can achieve high-efficient combustion while maintaining NOx/NH 3 emissions within reasonable levels.
    Type of Medium: Online Resource
    ISSN: 1468-0874 , 2041-3149
    URL: Article
    DOI: 10.1177/14680874221124452
    RVK:
    ZG 1100
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2030603-9
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  • 5
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    Effect of 3-methoxysalicylaldehyde on transparency and mechanical properties of EP modified with aminopyridine-based DOPO derivative
    SAGE Publications ; 2023
    In:  High Performance Polymers Vol. 35, No. 4 ( 2023-05), p. 401-411
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 35, No. 4 ( 2023-05), p. 401-411
    Abstract: Two effective flame retardant additives hsalaminopyridine phosphaphenanthrene (HAD) and methoaminopyridine phosphaphenanthrene (MAD) were respectively prepared with DOPO, aminopyridine, salicylaldehyde and 3-Methoxysalicylaldehyde. Subsequently, HAD and MAD was added into epoxy resin (EP) respectively, and flame retardancy of EP/HAD and EP/MAD thermosets were dramatically enhanced. The result of cone calorimeter (CC) test revealed that both HAD and MAD showed perfect smoke suppression performance. In respect of transmittance and mechanical properties, there was a huge difference between HAD and MAD. The introduction of HAD dramatically harmed transmittance and mechanical properties of EP, while, EP/10%MAD was transparent and nearly possessed the same mechanical properties with pure EP.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/09540083221142758
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 1483713-4
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  • 6
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    Irreversible electroporation ablation against subcutaneously implanted VX 2 tumors in rabbits: findings of shearwave ultrasound elastography
    SAGE Publications ; 2021
    In:  Scottish Medical Journal Vol. 66, No. 1 ( 2021-02), p. 23-28
    Details
    In: Scottish Medical Journal, SAGE Publications, Vol. 66, No. 1 ( 2021-02), p. 23-28
    Abstract: This study aimed to evaluate stiffness changes of rabbit subcutaneous VX 2 tumors before and after irreversible electroporation (IRE) ablationby shearwave ultrasound elastography (SWE). Methods IRE was performed on 20 subcutaneously implanted VX 2 tumors in rabbits (R-SIVX 2 ). Tumor stiffness was measured by SWE at different time points (before IRE,120minutes after IRE,7 days after IRE and 14 days after IRE). Results Before IRE, the mean stiffness (E mean ) of tumors was (10.45 ± 1.07) KPa. 120 minutes after I RE, the E mean of tumors obviously rose to (70.53 ± 9.87) KPa. 7 days after IRE, the E mean of tumors decreased to (40.22 ± 9.01) KPa. 14 days after IRE, the E mean of tumors was (15.17 ± 1.00) KPa. A clear boundary was observed between the ablation area and the normal tissues in the pathological results. Conclusions The stiffness of the VX 2 tumors experienced a first rise process and tend to be normal in the procedure of IRE. SWE could provide tissue stiffness information of different IRE ablation period as a non-invasive method.
    Type of Medium: Online Resource
    ISSN: 0036-9330 , 2045-6441
    URL: Article
    DOI: 10.1177/0036933020954178
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 7
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    Predictive Value of Preoperative Short Form-36 Survey Scale for Postoperative Axial Neck Pain in Patients With Degenerative Cervical Myelopathy
    SAGE Publications ; 2023
    In:  Global Spine Journal
    Details
    In: Global Spine Journal, SAGE Publications
    Abstract: Prospective observational study. Objective To evaluate the predictive value of the preoperative Short Form-36 survey (SF-36) scale for postoperative axial neck pain (ANP) in patients with degenerative cervical myelopathy (DCM) who underwent anterior cervical decompression and fusion (ACDF) surgery. Methods This study enrolled patients with DCM who underwent ACDF surgery at author’s Hospital between May 2010 and June 2016. Results Out of 126 eligible patients, 122 completed the 3-month follow-up and 117 completed the 1-year follow-up. The results showed that the preoperative social functioning (SF) subscale score of the SF-36 scale was significantly lower in patients with moderate-to-severe postoperative ANP than in those with no or mild postoperative ANP at both follow-up timepoints ( P 〈 .05). ACDF at C4-5 level resulted in a higher ANP rate than ACDF at C5-6 or C6-7 level, both at 3-month ( P = .019) and 1-year ( P = .004) follow-up. Multivariate logistic regression analysis confirmed that the preoperative social functioning subscale score was an independent risk factor for moderate-to-severe postoperative ANP at 3 months and 1 year after surgery, and preoperative NRS was an independent risk factor at 1-year follow-up. No other demographic, clinical, or radiographic factors were found to be associated with postoperative ANP severity ( P 〈 .05). Conclusions Preoperative social functioning subscale score of SF-36 scale might be a favorable predictive tool for postoperative ANP in DCM patients who underwent ACDF surgery.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/21925682231200136
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2648287-3
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  • 8
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    Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials
    SAGE Publications ; 2018
    In:  Journal of International Medical Research Vol. 46, No. 1 ( 2018-01), p. 22-32
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 46, No. 1 ( 2018-01), p. 22-32
    Abstract: This study was a meta-analysis of randomized controlled trials (RCTs) of ranitidine as an adjunct for antipsychotic-induced weight gain in patients with schizophrenia. RCTs reporting weight gain or metabolic side effects in patients with schizophrenia were included. Case reports/series, non-randomized or observational studies, reviews, and meta-analyses were excluded. The primary outcome measures were body mass index (BMI) (kg/m 2 ) and body weight (kg). Four RCTs with five study arms were identified and analyzed. Compared with the control group, adjunctive ranitidine was associated with marginally significant reductions in BMI and body weight. After removing an outlier study for BMI, the effect of ranitidine remained significant. Adjunctive ranitidine outperformed the placebo in the negative symptom score of the Positive and Negative Syndrome Scale. Although ranitidine was associated with less frequent drowsiness, other adverse events were similar between the two groups. Adjunctive ranitidine appears to be an effective and safe option for reducing antipsychotic-induced weight gain and improving negative symptoms in patients with schizophrenia. Larger RCTs are warranted to confirm these findings. Trial registration PROSPERO: CRD42016039735
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060517716783
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2082422-1
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  • 9
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    Structure and performance changes of high-modulus and low-shrinkage poly (ethylene terephthalate) industrial fibers under different heat treatment conditions
    SAGE Publications ; 2022
    In:  Textile Research Journal Vol. 92, No. 11-12 ( 2022-06), p. 2019-2030
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 92, No. 11-12 ( 2022-06), p. 2019-2030
    Abstract: For different heat treatments, the changes in overall performance features such as tenacity, modulus, load at 5% strain and elongation at a load of 4.0 cN/dtex of high modulus low shrinkage poly (ethylene terephthalate) industrial fibers were compared. The variations in the mechanical behavior were linked to adjustments in the microstructure, as determined by Fourier transform infrared spectroscopy, wide-angle X-ray diffraction and small-angle X-ray scattering. The results confirmed that the tenacity of the fibers is less dependent on the heat treatment conditions, whereas the modulus, load at 5% strain and elongation at a load of 4.0 cN/dtex differ significantly, which could reflect the stability of the fibers in use. The intact crystal structure and the constrained conformation adjustment of molecular chains in amorphous after heat treatment are responsible for the excellent tenacity retention of high modulus low shrinkage poly (ethylene terephthalate) fibers. With a low pre-tension and a higher heating temperature, the molecular chains in the amorphous region relax and disorient, resulting in a lower modulus and load at 5% strain. Instead, in the case of high pre-tension, heat treatment prolongation or temperature increase helps to rearrange the amorphous region into an ordered structure, which can improve the initial modulus and load at 5% strain of the fibers.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/00405175221075055
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2209596-2
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  • 10
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    Efficient Genetic Modification of Cynomolgus Monkey Embryonic Stem Cells with Lentiviral Vectors
    SAGE Publications ; 2010
    In:  Cell Transplantation Vol. 19, No. 9 ( 2010-09), p. 1181-1193
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 19, No. 9 ( 2010-09), p. 1181-1193
    Abstract: Embryonic stem (ES) cells have the ability to undergo indefinite self-renewal in vitro and give rise during development to derivatives of all three primary germ layers (ectoderm, endoderm, and mesoderm), which make them a highly prized reagent in cell and gene therapy. Efficient introduction of various genes of interest into primate ES cells has proven to be difficult. Here, we demonstrated that the self-inactivating HIV-1-based lentiviral vectors constructed by MultiSite gateway technology are efficient tools for the transduction of cynomolgus monkey ( Macaca fasicularis) ES (cmES) cells. After antibiotic selection, all of the transduced cells can stably express the reporter gene (humanized Renilla GFP or dTomato) while maintaining their stem cell properties, including continuous expression of stem cell markers, alkaline phosphatase (AKP), OCT-4, SSEA-4, and TRA-1-60, formation of embryoid bodies in vitro and teratomas in vivo containing derivatives of three embryonic germ layers. This approach will provide a useful tool for both gene function studies and in vivo cell tracking of stem cells.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368910X504469
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2020466-8
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