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  • 1
    Online Resource
    Online Resource
    Multifunctional Crystal Regulation Enables Efficient and Stable Sky‐Blue Perovskite Light‐Emitting Diodes
    Wiley ; 2022
    In:  Advanced Functional Materials Vol. 32, No. 41 ( 2022-10)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 32, No. 41 ( 2022-10)
    Abstract: Perovskite light‐emitting didoes (PeLEDs) have shown considerable potential in solution‐processable display applications. However, the performance of blue PeLEDs in terms of efficiency and stability hinders their practicality on account of severe trap‐mediated nonradiative recombination losses and halide phase segregation. To ameliorate these issues, mixed‐halide sky‐blue perovskite materials are strategically modulated through crystal defect passivation with a trifurcate isocyanate oligomer, which leads to the synergistical suppression of charge trap density and halide ion migration. The proposed approach enables the performance improvement for sky‐blue PeLEDs, exhibiting a peak external quantum efficiency of 14.82% and spectrally stable emission at 487 nm. In addition, prolonged operational lifetime and enhanced capability of moisture resistance are achieved simultaneously, approaching a half‐lifetime of ≈2900 s at an initial brightness of 178 cd m –2 .
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v32.41
    DOI: 10.1002/adfm.202206574
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Exploration of the Defect Passivation in Perovskite Materials Using Organic Spacer Cations
    Wiley ; 2022
    In:  Advanced Materials Interfaces Vol. 9, No. 10 ( 2022-04)
    Details
    In: Advanced Materials Interfaces, Wiley, Vol. 9, No. 10 ( 2022-04)
    Abstract: Quasi‐2D metal halide perovskite light emitting diodes (PeLEDs) have attracted a lot of attentions in recent years, while their potential applications in displays and lighting are limited by the device stability. Although defect passivation in PeLEDs is an effective method to ameliorate the unstable problem, the underlying mechanisms need to be further explored. Herein, organic spacer cations with different charge distributions and formation energies in quasi‐2D CsPbBr 3 perovskites are utilized to unravel the defect passivation mechanisms, including phenylmethanamine, 2‐phenylethanamine bromide, and 4‐phenylbutylammonium. The experimental findings and density functional theory calculation reveal that the defect passivation occurs by the electrostatic interaction between defective PbBr 6 4− octahedrons and proper organic spacer cations during the annealing process, particularly at the grain boundaries. The thermal stability of the perovskite films and device performance are improved after the effective defect passivation process. The exploration of the defect passivation process in perovskites will be beneficial to the development of high‐performance PeLEDs.
    Type of Medium: Online Resource
    ISSN: 2196-7350 , 2196-7350
    URL: Issue
    URL: Article
    DOI: 10.1002/admi.v9.10
    DOI: 10.1002/admi.202102253
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2750376-8
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  • 3
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    Online Resource
    Linking the low‐density lipoprotein receptor‐binding segment enables the therapeutic 5‐YHEDA peptide to cross the blood‐brain barrier and scavenge excess iron and radicals in the brain of senescent mice
    Wiley ; 2019
    In:  Alzheimer's & Dementia: Translational Research & Clinical Interventions Vol. 5, No. 1 ( 2019-01), p. 717-731
    Details
    In: Alzheimer's & Dementia: Translational Research & Clinical Interventions, Wiley, Vol. 5, No. 1 ( 2019-01), p. 717-731
    Abstract: Iron accumulates in the brain during aging, which catalyzes radical formation, causing neuronal impairment, and is thus considered a pathogenic factor in Alzheimer's disease (AD). To scavenge excess iron‐catalyzed radicals and thereby protect the brain and decrease the incidence of AD, we synthesized a soluble pro‐iron 5‐YHEDA peptide. However, the blood‐brain barrier (BBB) blocks large drug molecules from entering the brain and thus strongly reduces their therapeutic effects. However, alternative receptor‐ or transporter‐mediated approaches are possible. Methods A low‐density lipoprotein receptor (LDLR)‐binding segment of Apolipoprotein B‐100 was linked to the 5‐YHEDA peptide (bs‐5‐YHEDA) and intracardially injected into senescent (SN) mice that displayed symptoms of cognitive impairment similar to those of people with AD. Results We successfully delivered 5‐YHEDA across the BBB into the brains of the SN mice via vascular epithelium LDLR‐mediated endocytosis. The data showed that excess brain iron and radical‐induced neuronal necrosis were reduced after the bs‐5‐YHEDA treatment, together with cognitive amelioration in the SN mouse, and that the senescence‐associated ferritin and transferrin increase, anemia and inflammation reversed without kidney or liver injury. Discussion bs‐5‐YHEDA may be a mild and safe iron remover that can cross the BBB and enter the brain to relieve excessive iron‐ and radical‐induced cognitive disorders.
    Type of Medium: Online Resource
    ISSN: 2352-8737 , 2352-8737
    URL: Article
    DOI: 10.1016/j.trci.2019.07.013
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2832891-7
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  • 4
    Online Resource
    Online Resource
    Isotemporal substitution of different behaviour patterns with the presence of MAFLD in Chinese adults
    Wiley ; 2022
    In:  Liver International Vol. 42, No. 12 ( 2022-12), p. 2683-2695
    Details
    In: Liver International, Wiley, Vol. 42, No. 12 ( 2022-12), p. 2683-2695
    Abstract: Lack of physical activity and excessive sitting time contributed to ectopic fat accumulation, especially in the liver. Previous studies have illustrated the harm of sedentary behaviour and the benefits of physical activity on fatty liver disease. We aimed to explore the association between the behaviour patterns and the risk of metabolic dysfunction‐associated fatty liver disease (MAFLD) using isotemporal substitution model to examine the effect of replacing one behaviour to another while keeping the total time and other behaviours fixed among Chinese middle‐aged and elderly population. Methods This study included 161 147 participants aged ≥40 years old from the nationwide, population‐based cohort of the REACTION study. The International Physical Activity Questionnaire was used to measure self‐reported time for sleeping, sitting, walking and moderate‐to‐vigorous physical activity (MVPA). MAFLD was defined by evidence of fatty liver index (FLI) ≥ 60 in addition to one of the following three patterns, namely overweight/obesity, presence of diabetes, or evidence of metabolic dysregulation. Isotemporal substitution models using logistic regression models to evaluate the association of replacement of different behaviour patterns with each other and the risk of MAFLD. Results Substitution of 60 minutes per day of sleeping, walking or total MVPA for sitting was associated with a 2%–8% reduction of MAFLD risk in overall participants. In employed individuals, replacing sitting time with occupational MVPA or nonoccupational MVPA both could bring benefits to liver steatosis. Stratified analysis found that replacing 60 minutes of sitting time with an equivalent time of other behaviour pattern could reduce approximately 8% of the risk among MAFLD participants with metabolic abnormalities. Such a relationship might be explained by the important mediated role of metabolic elements, such as waist circumference, body mass index, triglycerides and homoeostasis model assessment of insulin resistance. Furthermore, replacing sitting with MVPA showed a stronger association among participants who got enough sleep (sleep duration ≥7 hours per day). Conclusion Replacing sitting with other behaviour patterns could reduce the prevalence of MAFLD, and such substitution effect was much remarkably in individuals with abnormal metabolic status. Observably, obese individuals were more likely to benefit from appropriate changes in behaviour patterns. Moreover, the analysis of sleep duration stratification appealed that the adequacy of individual sleep duration also had a significant impact on the substitution effect. It is worth noting that adjusting the time allocation of behaviour patterns might have a beneficial impact on liver‐metabolic health, and these findings might help us better recognize the importance of reasonable arrangement of behaviour patterns according to the individual's situation.
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Issue
    URL: Article
    DOI: 10.1111/liv.v42.12
    DOI: 10.1111/liv.15439
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2124684-1
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  • 5
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    Online Resource
    Association between the change in body mass index from early adulthood to midlife and subsequent type 2 diabetes mellitus
    Wiley ; 2016
    In:  Obesity Vol. 24, No. 3 ( 2016-03), p. 703-709
    Details
    In: Obesity, Wiley, Vol. 24, No. 3 ( 2016-03), p. 703-709
    Abstract: To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife. Methods This study included 120,666 middle‐aged and elderly, whose retrospectively self‐reported body weight at 20 and 40 years and measured height were available. BMI at 20 and 40 years and BMI change in between were defined as early‐adulthood BMI, midlife BMI, and early‐adulthood BMI change. Results The odds ratio (OR) for T2DM associated with an 1‐unit increment of early‐adulthood or midlife BMI was 1.08 (95% confidence interval (CI), 1.07‐1.08) and 1.09 (95% CI, 1.09‐1.10) respectively. In the cross‐tabulation of both early‐adulthood BMI and BMI change, the prevalence of T2DM increased across both variables. Compared with participants with normal early‐adulthood weight and BMI increase/decrease ≤1, the OR (95% CI) for T2DM of participants with early‐adulthood overweight/obesity and BMI increase ≥4 kg/m 2 was 3.49 (3.05‐4.00). For participants with early‐adulthood underweight and BMI increase/decrease ≤ 1, the OR (95% CI) was 0.85 (0.75‐0.97). Subgroup analysis according to sex and age showed similar trends. Conclusions Early‐adulthood BMI may influence T2DM prevalence after midlife independent of current BMI. T2DM prevalence after midlife was positively associated with early‐adulthood weight gain and inversely related to early‐adulthood weight loss, while early‐adulthood weight loss could not completely negate the adverse effect of early‐adulthood overweight/obesity on diabetes.
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    URL: Issue
    URL: Article
    DOI: 10.1002/oby.v24.3
    DOI: 10.1002/oby.21336
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2027211-X
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  • 6
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    Online Resource
    Glycemic status and chronic kidney disease in C hinese adults: F indings from the REACTION study : 中国成年人糖代谢状态与慢性肾脏疾病的相关性:来自REACTION的研究发现
    Wiley ; 2017
    In:  Journal of Diabetes Vol. 9, No. 9 ( 2017-09), p. 837-845
    Details
    In: Journal of Diabetes, Wiley, Vol. 9, No. 9 ( 2017-09), p. 837-845
    Abstract: 既往研究证实已诊断的糖尿病与慢性肾脏疾病(chronic kidney disease,CKD)具有相关性。然而,关于糖尿病前期高血糖是否与升高的CKD风险有关尚不明确。本研究旨在探讨中国成年人群不同糖代谢水平与CKD的相关性,并评估和讨论CKD患者的糖尿病患病率及血糖控制现状。 方法 本研究共纳入250752名40岁及以上受试者,均来自中国2型糖尿病患者恶性肿瘤发生风险的流行病学研究(Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study,REACTION study)的基线研究人群,并对所有受试者进行血糖、生化检测以及其他临床资料的收集。估算的肾小球滤过率(eGFR) 〈 60mL/min/1.73m 2 被定义为CKD。 结果 在男性和女性中,均可以观察到CKD的患病率随着糖代谢状态的恶化逐渐升高(男性和女性均为趋势 P 〈 0.001)。在男性中,与糖代谢正常的受试者相比,糖尿病前期与糖尿病人群的CKD患病风险增高(糖尿病前期:OR=1.15,95% CI = 1.02‐1.32;新诊断糖尿病:OR=1.27, 95% CI = 1.08‐1.49;已诊断糖尿病:OR=2.05,95% CI = 1.78‐2.35)。在女性中也发现了糖尿病与CKD患病风险的相关性,但是,女性糖尿病前期人群与CKD患病的相关性无统计学意义。在伴有糖尿病的男性CKD患者中,接受降糖治疗的比例是52.1%,其中41.8%患者的糖尿病得到了有效控制,该比例高于女性人群。 结论 在中国40岁及以上成年男性中,糖尿病前期状态和糖尿病与CKD患病风险的升高密切相关。中国CKD患者中血糖的控制情况不容乐观。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.2017.9.issue-9
    DOI: 10.1111/1753-0407.12490
    Language: English
    Publisher: Wiley
    Publication Date: 2017
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  • 7
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    Cohort profile: Risk evaluation of cancers in C hinese diabetic individuals: a longitudinal ( REACTION ) study (队列简介：中国糖尿病患者肿瘤发生风险的纵向研究（REACTION研究）)
    Wiley ; 2014
    In:  Journal of Diabetes Vol. 6, No. 2 ( 2014-03), p. 147-157
    Details
    In: Journal of Diabetes, Wiley, Vol. 6, No. 2 ( 2014-03), p. 147-157
    Abstract: 评估在中国人群中糖代谢异常（糖尿病及糖尿病早期）是否与肿瘤风险增加相关，并寻找糖代谢异常人群中影响肿瘤风险的因素。 方法 2011‐2012年间，来自中国大陆地区25个研究中心的259657名年龄在40岁以上的社区居民被招募参加了REACTION研究的基线调查，并将在第3、5、10年接受随访。每位参与者接受了详细的生活方式问卷调查、体格检查及生化检测，并留取了生物样本，包括血清、尿液和抽提DNA所需的全血标本。 结果 该队列的平均年龄为57 ± 10岁。已诊断和新诊断糖尿病的患者分别占10.32%和10.57%。肿瘤患者总4511例（男性988例，女性3523例），患病率为1.79%。与糖耐量正常的人群相比，校正各类混杂因素后，男性糖尿病患者的胃癌患病比（prevalence ratio，PR）显著降低（PR：0.38，95% CI：0.16–0.89）， 女性糖尿病患者所有癌症（PR：1.36，95% CI：1.20–1.56）、乳腺癌（PR：1.56，95% CI：1.21–2.00）、子宫内膜癌（PR：1.58，95% CI：1.16–2.15）、甲状腺癌（PR：1.53，95% CI：1.03–2.27）的患病比显著增加。 结论 多中心的REACTION研究在259657例中国自然人群中收集了大量的有关体格、精神、代谢及健康状况、生化指标及和生活方式信息的数据。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.2014.6.issue-2
    DOI: 10.1111/1753-0407.12108
    Language: English
    Publisher: Wiley
    Publication Date: 2014
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  • 8
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    Phosphonate‐influenced Diels‐Alder chemistry toward multi‐path recyclable, fire safe thermoset and its carbon fiber composites
    Wiley ; 2023
    In:  EcoMat Vol. 5, No. 9 ( 2023-09)
    Details
    In: EcoMat, Wiley, Vol. 5, No. 9 ( 2023-09)
    Abstract: Dynamic covalent chemistry offers a solution to tackle the recycling issue of epoxy resins (EPs) and their carbon fiber‐reinforced composites; however, the vulnerability to creep associated with the inflammable nature of the EPs are the key obstacles for their applications. Herein, we propose a feasible and facile strategy to overcome these obstacles by incorporating phosphorus‐influenced Diels‐Alder (DA) chemistry to construct dynamic epoxy networks. In the strategy, the electron‐withdrawing phosphonate in the dienophile maleimide greatly promotes the thermal stability of the DA reaction, exhibiting excellent creep resistance, repairability, and malleability; while its flame‐retardant activity improves the fire safety of the resultant thermosets. Meanwhile, nondestructive recycling of carbon fiber is achieved. The ease with which EP and its composites can be manufactured, used, recycled and re‐used–without losing service performance–points to new orientation in sustainable composites. image
    Type of Medium: Online Resource
    ISSN: 2567-3173 , 2567-3173
    URL: Issue
    URL: Article
    DOI: 10.1002/eom2.v5.9
    DOI: 10.1002/eom2.12388
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2902933-8
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  • 9
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    Online Resource
    High concentrations of triglycerides are associated with diabetic kidney disease in new‐onset type 2 diabetes in C hina: Findings from the C hina C ardiometabolic D isease and C ancer C ohort ( 4C ) S tudy
    Wiley ; 2021
    In:  Diabetes, Obesity and Metabolism Vol. 23, No. 11 ( 2021-11), p. 2551-2560
    Details
    In: Diabetes, Obesity and Metabolism, Wiley, Vol. 23, No. 11 ( 2021-11), p. 2551-2560
    Abstract: The aims of this study were to evaluate the associations of metabolic abnormalities with incident diabetic kidney disease (DKD) and to explore whether dyslipidaemia, particularly high fasting triglyceride (TG), was associated with the development of DKD. Methods In total, 11 142 patients with new‐onset type 2 diabetes with baseline estimated glomerular filtration rates (eGFR) ≥60 mL/min/1.73 m 2 were followed up during 2011‐2016. Incident DKD was defined as eGFR 〈 60 mL/min/1.73 m 2 at follow‐up. Multiple logistic regression analysis was conducted to explore the relationship of metabolic abnormalities at baseline and at follow‐up with risks of DKD. High TG was defined by TG ≥1.70 mmol/L. Low high‐density lipoprotein cholesterol (HDL‐c) was defined by HDL‐c 〈 1.0 mmol/L for men or 〈 1.3 mmol/L for women. Results Participants who developed DKD had higher levels of waist circumference and systolic blood pressure, and lower levels of HDL‐c at both baseline and follow‐up visits. The DKD group also had higher levels of post‐load plasma glucose and TG at follow‐up. Multivariate logistic regression analysis revealed that both high TG at baseline [odds ratio (OR) = 1.37, p  = .012) and high TG at follow‐up (OR = 1.71, p   〈  .001) were significantly associated with increased risks of DKD. Patients with high TG levels at both baseline and follow‐up had higher risk of DKD compared with constantly normal TG (OR = 1.65, p   〈  .001) after adjustment for covariates. Conclusions In a large population of patients with new‐onset type 2 diabetes, a high TG level was an independent risk factor for the development of DKD. Tight TG control might delay the occurrence of DKD.
    Type of Medium: Online Resource
    ISSN: 1462-8902 , 1463-1326
    URL: Issue
    URL: Article
    DOI: 10.1111/dom.v23.11
    DOI: 10.1111/dom.14502
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2004918-3
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  • 10
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    Online Resource
    The association between age at diagnosis of type 2 diabetes and albuminuria in Chinese adults: A nationwide population study
    Wiley ; 2021
    In:  Journal of Diabetes Vol. 13, No. 12 ( 2021-12), p. 987-997
    Details
    In: Journal of Diabetes, Wiley, Vol. 13, No. 12 ( 2021-12), p. 987-997
    Abstract: 2型糖尿病的诊断年龄在全球及中国呈年轻化的趋势。目前较少研究糖尿病诊断年龄与白蛋白尿患病风险的相关性。本研究拟探讨糖尿病诊断年龄是否为白蛋白尿风险相关的独立危险因素。 方法 我们使用了来自中国大陆207961名研究对象的全国多中心研究数据。从年龄、性别和研究中心匹配的非糖尿病人群中随机选择正常对照, 另外对已诊断糖尿病患者的病程进行匹配, 最终共有31366 名新诊断2型糖尿病患者和 31366名正常对照, 及7490名已诊断2型糖尿病和7490名正常对照纳入分析。使用多元Logistic回归分析在不同糖尿病诊断年龄层中2型糖尿病患者与正常对照患白蛋白尿的风险。 结果 虽然年龄越大, 白蛋白尿患病风险越高, 但是2型糖尿病患者与正常对照组白蛋白尿的比值比随着诊断年龄的增加而降低。与正常对照组相比, 年龄 〈 50、50‐59、60‐69 或≥70 岁诊断为糖尿病的患者经过多变量校正后白蛋白尿风险仍然增加, 新诊断糖尿病分别增加了 81%、60%、45% 和 33%, 已诊断糖尿病分别增加了 135%、121%、90% 和 58%。 结论 在中国成人中, 2型糖尿病诊断年龄越低, 其白蛋白尿风险升高越明显。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.v13.12
    DOI: 10.1111/1753-0407.13213
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2485432-3
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