In:
Polymer International, Wiley, Vol. 61, No. 7 ( 2012-07), p. 1151-1157
Abstract:
Microgel particles were prepared, made of hydroxypropylcellulose‐ graft ‐(acrylic acid) (HPC‐ g ‐AA) and acrylic acid(AA). The particles undergo reversible volume phase transitions in response to both pH and temperature changes while keeping the inherent properties of PAA and HPC‐ g ‐AA. Dynamic light scattering measurements reveal that the average hydrodynamic radius and hydrodynamic radius distributions of the microgel particles depend on temperature and pH. The microgels exhibit excellent pH sensitivity and a higher swelling ratio at higher pH in aqueous solution. In vitro release study shows that the amount of insulin released from the microgels is less at pH = 1.2 than at pH = 6.8. The results indicate that the resultant microgels seem to be of great potential for intelligent oral drug delivery. Copyright © 2012 Society of Chemical Industry
Type of Medium:
Online Resource
ISSN:
0959-8103
,
1097-0126
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2004753-8
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