In:
Chemical Biology & Drug Design, Wiley, Vol. 86, No. 6 ( 2015-12), p. 1548-1553
Abstract:
The facile synthesis of core–shell magnetic mesoporous silica nanoparticles (Fe 3 O 4 @ mSiO 2 NP s) was reported in aqueous phase using cetyltrimethylammonium bromide as a template under alcohol‐free conditions. Compared to the conventional synthesis method for core–shell Fe 3 O 4 @ mSiO 2 NP s, the approach in this study is rapid (only 5‐min reaction time), cheap (without using organic agents), and environmentally friendly (one‐step synthesis in alcohol‐free medium). Doxorubicin ( DOX )‐loaded Fe 3 O 4 @ mSiO 2 NP s exert extraordinarily high specificity for liver cancer cells, which was due to the pH ‐sensitive doxorubicin release, as well as higher endocytosis capacity in liver cancer cells rather than normal liver cells. The potential advantages of using such Fe 3 O 4 @ mSiO 2 NP s as the vehicle of anticancer drugs were that the Fe 3 O 4 @ mSiO 2 NP s exhibit good biocompatibility, high loading and protection of the guest molecules, selective killing effect, and efficient cellular uptake. The exciting pH ‐dependent release properties of doxorubicin‐loaded Fe 3 O 4 @ mSiO 2 NP s make their use a promising strategy for enhancing efficient therapy toward tumors, while reducing the cytotoxicity of doxorubicin to human normal neutral tissue or cells.
Type of Medium:
Online Resource
ISSN:
1747-0277
,
1747-0285
DOI:
10.1111/cbdd.2015.86.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2216600-2
SSG:
12
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