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  • Wiley  (53)
  • Chen, Kang  (53)
  • 1
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    Relationship between the Virtual Dynamic Thinning Line and the Self‐Thinning Boundary Line in Simulated Plant Populations
    Wiley ; 2008
    In:  Journal of Integrative Plant Biology Vol. 50, No. 3 ( 2008-03), p. 280-290
    Details
    In: Journal of Integrative Plant Biology, Wiley, Vol. 50, No. 3 ( 2008-03), p. 280-290
    Abstract: The self‐thinning rule defines a straight upper boundary line on log‐log scales for all possible combinations of mean individual biomass and density in plant populations. Recently, the traditional slope of the upper boundary line, −3/2, has been challenged by −4/3 which is deduced from some new mechanical theories, like the metabolic theory. More experimental or field studies should be carried out to identify the more accurate self‐thinning exponent. But it's hard to obtain the accurate self‐thinning exponent by fitting to data points directly because of the intrinsic problem of subjectivity in data selection. The virtual dynamic thinning line is derived from the competition‐density (C‐D) effect as the initial density tends to be positive infinity, avoiding the data selection process. The purpose of this study was to study the relationship between the virtual dynamic thinning line and the upper boundary line in simulated plant stands. Our research showed that the upper boundary line and the virtual dynamic thinning line were both straight lines on log‐log scales. The slopes were almost the same value with only a very little difference of 0.059, and the intercept of the upper boundary line was a little larger than that of the virtual dynamic thinning line. As initial size and spatial distribution patterns became more uniform, the virtual dynamic thinning line was more similar to the upper boundary line. This implies that, given appropriate parameters, the virtual dynamic thinning line may be used as the upper boundary line in simulated plant stands.
    Type of Medium: Online Resource
    ISSN: 1672-9072 , 1744-7909
    URL: Issue
    URL: Article
    DOI: 10.1111/jipb.2008.50.issue-3
    DOI: 10.1111/j.1744-7909.2007.00618.x
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2130095-1
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  • 2
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    Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress
    Wiley ; 2021
    In:  Cell Proliferation Vol. 54, No. 11 ( 2021-11)
    Details
    In: Cell Proliferation, Wiley, Vol. 54, No. 11 ( 2021-11)
    Abstract: Maternal factors that are enriched in oocytes have attracted great interest as possible key factors in somatic cell reprogramming. We found that surfeit locus protein 4 (Surf4), a maternal factor, can facilitate the generation of induced pluripotent stem cells (iPSCs) previously, but the mechanism remains elusive. Materials and Methods In this study, we investigated the function and mechanism of Surf4 in somatic cell reprogramming using a secondary reprogramming system. Alkaline phosphatase (AP) staining, qPCR and immunofluorescence (IF) staining of expression of related markers were used to evaluate efficiency of iPSCs derived from mouse embryonic fibroblasts. Embryoid body and teratoma formation assays were performed to evaluate the differentiation ability of the iPSC lines. RNA‐seq, qPCR and western blot analysis were applied to validate the downstream targets of Surf4. Results Surf4 can significantly facilitate the generation of iPSCs in a proliferation‐independent manner. When co‐expressed with Oct4, Sox2, Klf4 and c‐Myc (OSKM), Surf4 can activate the response to endoplasmic reticulum (ER) stress at the early stage of reprogramming. We further demonstrated that Hspa5, a major ER chaperone, and the active spliced form of Xbp1 (sXbp1), a major mediator of ER stress, can mimic the effects of Surf4 on somatic cell reprogramming. Concordantly, blocking the unfolded protein response compromises the effect of Surf4 on reprogramming. Conclusions Surf4 promotes somatic cell reprogramming by activating the response to ER stress.
    Type of Medium: Online Resource
    ISSN: 0960-7722 , 1365-2184
    URL: Issue
    URL: Article
    DOI: 10.1111/cpr.v54.11
    DOI: 10.1111/cpr.13133
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2019986-7
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  • 3
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    Photo‐Enhanced Synergistic Induction of Ferroptosis for Anti‐Cancer Immunotherapy
    Wiley ; 2023
    In:  Advanced Healthcare Materials
    Details
    In: Advanced Healthcare Materials, Wiley
    Abstract: Ferroptosis as programmed cell death received considerable attention in cancer research. Recently, studies have associated ferroptosis with photodynamic therapy (PDT) because PDT promotes glutathione (GSH) deletion, glutathione peroxidase 4 (GPX4) degradation, and lipid peroxide accumulation. However, PDT‐induced ferroptosis may be potentially prevented by ferroptosis suppressor protein 1 (FSP1). To address this limitation, herein, a novel strategy is developed to trigger ferroptosis by PDT and FSP1 inhibition. For enhancement of this strategy, a photoresponsive nanocomplex, self‐assembled by BODIPY‐modified poly(amidoamine) (BMP), is utilized to stably encapsulate the inhibitor of FSP1 (iFSP1) and chlorin e6 (Ce6). The nanosystem promotes intracellular delivery, penetration, and accumulation of ferroptosis inducers in tumors with light irradiation. The nanosystem presents high‐performance triggering of ferroptosis and immunogenic cell death (ICD) in vitro and in vivo. Importantly, the nanoparticles increase tumor infiltration of CD8 + T cells and further enhance the efficacy of anti‐PD‐L1 immunotherapy. The study suggests the potential of photo‐enhanced synergistic induction of ferroptosis by the photoresponsive nanocomplexes in cancer immunotherapy.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Article
    DOI: 10.1002/adhm.202300994
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2645585-7
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  • 4
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    Visceral adiposity index is closely associated with urinary albumin‐creatinine ratio in the Chinese population with prediabetes
    Wiley ; 2021
    In:  Diabetes/Metabolism Research and Reviews Vol. 37, No. 7 ( 2021-10)
    Details
    In: Diabetes/Metabolism Research and Reviews, Wiley, Vol. 37, No. 7 ( 2021-10)
    Abstract: Visceral obesity is a major health issue and is a risk factor for an atherogenic state. Visceral obesity has been reported to be a crucial link between albuminuria and cardiovascular diseases (CVD). This study attempted to explore the association between visceral obesity and albuminuria in prediabetic individuals. Methods This cross‐sectional study included 24871 prediabetic participants over 40 years of age from seven centres across China (REACTION study). The visceral adiposity index (VAI) was determined based on the measurements of anthropometric indices and lipid parameters. Increased albuminuria was defined as a urinary albumin‐creatinine ratio (UACR) ≥30 mg/g, indicating kidney damage. Propensity score matching was used to reduce bias, and a multiple logistic regression model was performed to evaluate the association between visceral obesity and albuminuria in the population with prediabetes. Results Participants with increased UACR exhibited increased VAI, age, blood pressure, triglycerides, poor glycaemic control, CVD events, and decreased estimated glomerular filtration rate (eGFR). Multiple logistic regression analysis demonstrated that VAI quartiles were positively associated with an increased risk of albuminuria (Q2: odds rate [OR]: 1.10, 95% confidence intervals [CI] 0.96–1.25; Q3: OR: 1.16, 95% CI 1.01–1.32; Q4: OR: 1.26, 95% CI 1.10–1.44, p for trend = 0.001). Stratified analysis revealed that the association of VAI level with increased albuminuria risk also occurred in people who were young, women, overweight or obese, with poor control of blood pressure, and eGFR ≥90 ml/min per 1.73 m 2 . Conclusions Visceral obesity assessed by VAI is significantly associated with increased UACR in a Chinese population with prediabetes.
    Type of Medium: Online Resource
    ISSN: 1520-7552 , 1520-7560
    URL: Issue
    URL: Article
    DOI: 10.1002/dmrr.v37.7
    DOI: 10.1002/dmrr.3424
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2001565-3
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  • 5
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    Development of a PRiME cartridge purification method for rapid determination of malachite green and leucomalachite green in Chinese softshell turtle
    Wiley ; 2019
    In:  ELECTROPHORESIS Vol. 40, No. 11 ( 2019-06), p. 1615-1621
    Details
    In: ELECTROPHORESIS, Wiley, Vol. 40, No. 11 ( 2019-06), p. 1615-1621
    Abstract: A high‐throughput PRiME (process, robustness, improvements, matrix effects, ease of use) sample purification procedure was developed to simplify the multiple steps of traditional SPE in extracting the malachite green and leucomalachite green in Chinese softshell turtle ( Pelodiscus sinensis ). The sample loading volume, extracting solvent type, and pH value of the employed PRiME hydrophilic‐lipophilic balance cartridge for sample purification were optimized to be 3 mL, acetonitrile, and pH 5, respectively. In comparison with traditional SPE, the PRiME process is cost‐effective, solvent‐saving, and simple to operate, which only consists of a passing through step without traditional sorbent conditioning and impurity washing. Afterward, eluate was analyzed by ultra‐performance liquid chromatography‐tandem mass spectrometry, and the proposed method was validated for linearity (R 2 〉 0.9992), intraday precision (2.44–3.22%), interday precision (3.28–6.58%), sensitivity (LOD ≤ 0.18 μg/kg and, LOQ ≤ 0.60 μg/kg), and recovery (88.7–94.1%, RSD 〈 6.79%). The results indicated that the PRiME technique can simplify the sample preparation procedure by avoiding the tedious steps, such as conditioning, washing, etc. It would be of significant interest for environmental and food safety applications in the market of Chinese softshell turtle and related products.
    Type of Medium: Online Resource
    ISSN: 0173-0835 , 1522-2683
    URL: Issue
    URL: Article
    DOI: 10.1002/elps.v40.11
    DOI: 10.1002/elps.201900081
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1475486-1
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  • 6
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    Low‐grade albuminuria is associated with high cardiovascular risk in CVD ‐free and normoalbuminuric Chinese adults: Results from the REACTION study
    Wiley ; 2021
    In:  Journal of Diabetes Vol. 13, No. 8 ( 2021-08), p. 648-660
    Details
    In: Journal of Diabetes, Wiley, Vol. 13, No. 8 ( 2021-08), p. 648-660
    Abstract: 在无心血管疾病(CVD)且尿蛋白正常的中国成年人群中, 关于低度白蛋白尿(低于微量白蛋白尿阈值)与心血管高危风险的相关性研究数据有限。 方法 本研究共纳入来自中国7个中心的32650名40岁以上社区人群。收集晨尿测尿微量白蛋白与肌酐的比值(UACR), 分别在男性和女性中进行数据分析, 并根据UACR水平将各性别人群分成四分位。采用Framingham风险评分(FRS)计算参与者未来10年罹患冠心病(CHD)的风险, FRS ≥ 20%者被定义为未来10年患冠心病的风险为高危。建立Logistic回归模型, 分析低度白蛋白尿与未来10年冠心病高危风险的相关性。 结果 在男性和女性中, 冠心病高危因素如糖尿病、高血压和血脂异常的患病率随着UACR水平的升高而显著增加。Logistic回归分析显示, 从男性UACR第二分位(UACR: 4.78 ~ 7.53 mg/g, OR = 1.21, 95% [CI]: 1.05‐1.40)、女性第三分位(UACR:9.13 ~ 15.04 mg/g, OR = 3.07, 95% CI: 1.75‐5.40)开始, 随着UACR的升高, 未来10年冠心病高危风险的比值比(OR)明显增加。分层分析显示, 在老年、超重或肥胖、无糖尿病和无高血压的男性以及老年、超重或肥胖、无糖尿病和有高血压的女性中, 这种相关性最为显著。 结论 在无心血管疾病病史且尿蛋白正常的中国成年人群中, 低度白蛋白尿与未来10年冠心病高危风险显著相关。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.v13.8
    DOI: 10.1111/1753-0407.13152
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2485432-3
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  • 7
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    Association between nonalcoholic fatty liver and increased low‐level albuminuria in postmenopausal women in China: A cross‐sectional study
    Wiley ; 2021
    In:  Journal of Diabetes Vol. 13, No. 6 ( 2021-06), p. 494-505
    Details
    In: Journal of Diabetes, Wiley, Vol. 13, No. 6 ( 2021-06), p. 494-505
    Abstract: 有多项研究表明; 非酒精性脂肪肝(NAFLD)与心血管疾病(CVD)有关。低水平蛋白尿(LLA)的排泄随着CVD患病率的升高而增加。但是; 少有研究探索NAFLD和LLA之间的相关性。 方法 这项横断面研究包括31 147名中国成年人(7664名男性和23 483名女性)。由尿白蛋白与肌酐之比(UACR)确定白蛋白尿的“正常”水平为低于30 mg / g。 LLA被定义为“正常”蛋白尿范围内的较高水平(5.54 mg / g 〈 LLA≤29.9mg / g)。NAFLD的定义为脂肪肝指数(FLI)≥60。FLI使用Bedogni方程计算。 结果 通过多变量线性回归分析; UACR与FLI之间存在正相关(非标准化β±SE:0.047±0.004; P 〈 0.001)。逻辑回归分析显示; NAFLD比值比(OR)在调整混杂因素的模型1‐4中与LLA显着相关(所有受试者:OR; 1.207; 95%CI; 1.098‐1.326;女性:OR; 1.43; 95%CI; 1.26‐1.63；所有P 〈 0.001)；然而; 在调整混杂因素后; 我们没有发现男性之间有显著的OR。在分层分析中; 在24≤体重指数 〈 28 kg / m 2 、5.6≤ 空腹血糖 〈 7.0 mmol / L或7.8≤餐后血糖 〈 11.1 mmol / L以及60岁以下缺少中等强度运动的绝经后妇女中; NAFLD与LLA的相关性更为显著。 结论 在绝经后的妇女中; NAFLD和LLA之间存在显着的相关性; 且当这些妇女处于临界血糖值; 超重且缺少中等强度体育锻炼的状态下时; 两者的相关性更为明显。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.v13.6
    DOI: 10.1111/1753-0407.13134
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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  • 8
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    Facile Physical Modifications of Polymer Hole Transporting Layers for Efficient and Reproducible Perovskite Solar Cells with Fill Factor Exceeding 80%
    Wiley ; 2020
    In:  Solar RRL Vol. 4, No. 11 ( 2020-11)
    Details
    In: Solar RRL, Wiley, Vol. 4, No. 11 ( 2020-11)
    Abstract: The hole transport materials that interact with the indium tin oxide (ITO) surface can be processed into monomolecular layers (MLs), which often exhibit different surface and electronic properties than their thin‐film counterparts. Herein, it is found that poly[bis(4‐phenyl)(2,4,6‐trimethylphenyl)amine] (PTAA) films (R‐PTAA) can be easily processed into ML (M‐PTAA) due to the van der Waals interaction between ITO and PTAA. However, compared with R‐PTAA, the work function (WF) and conductivity of M‐PTAA are simultaneously reduced by the charge transfer at the ITO/PTAA interface. To address this issue, a modified monomolecular layer strategy (m‐MLS) is developed, where a small amount of 2,3,5,6‐tetrafluoro‐7,7,8,8‐tetracyanoquinodimethane (F4TCNQ) is introduced to enhance the interaction force between ITO and PTAA. PTAA treated by m‐MLS (F‐PTAA) has a hydrophilic physical surface, closely matching electronic energy level with the perovskite layer and smaller bulk resistance. As a result, the efficiency and reproducibility of perovskite solar cells (PSCs) are substantially improved. PSCs based on F‐PTAA demonstrated the highest power conversion efficiency (PCE) of 19.7% with a fill factor of over 80%. This study inspires the development of novel interface modification materials, and provides a simple and convenient direction for the fabrication of high‐performance and reproducible inverted PSCs with high fill factors.
    Type of Medium: Online Resource
    ISSN: 2367-198X , 2367-198X
    URL: Issue
    URL: Article
    DOI: 10.1002/solr.v4.11
    DOI: 10.1002/solr.202000365
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2882014-9
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  • 9
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    High‐throughput 96‐well solid‐phase extraction for preparation of tetracycline followed by liquid chromatography and mass spectrometry analysis
    Wiley ; 2019
    In:  ELECTROPHORESIS Vol. 40, No. 4 ( 2019-02), p. 555-562
    Details
    In: ELECTROPHORESIS, Wiley, Vol. 40, No. 4 ( 2019-02), p. 555-562
    Abstract: Tetracyclines abuse has frequently occurred in aquaculture against bacteria, rickettsiae, spirochetes, and mycoplasmas. In this study, a high‐throughput sample preparation method was developed using 96‐well plate solid‐phase extraction ( p ‐SPE) and the extract was analyzed by ultra‐performance liquid chromatography tandem mass spectrometry (UPLC‐MS/MS). The experimental conditions were optimized such that the pH is 4, the eluting solvent is methanol (2 mL), and the sorbent is hydrophilic‐lipophilic balance (HLB) microsphere. The whole protocol was validated, and it showed that the tetracyclines were linear with correlation coefficients ≥ 0.9990, precision and accuracy (RSD%) in 3.9–6.1%, and mean recoveries of 88.6–103.6%. To exhibit the potential of 96‐well p ‐SPE as a routine tool for inspection and quarantine, fresh aquatic samples were tested, and among which positive samples were observed. This method was demonstrated to be promising for the purification and enrichment of tetracyclines with reduced time and labor, and indeed practically and particularly suitable for widespread tetracyclines analysis.
    Type of Medium: Online Resource
    ISSN: 0173-0835 , 1522-2683
    URL: Issue
    URL: Article
    DOI: 10.1002/elps.v40.4
    DOI: 10.1002/elps.201800473
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1475486-1
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  • 10
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    A novel small‐molecule activator of procaspase‐3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts
    Wiley ; 2014
    In:  Molecular Oncology Vol. 8, No. 8 ( 2014-12), p. 1640-1652
    Details
    In: Molecular Oncology, Wiley, Vol. 8, No. 8 ( 2014-12), p. 1640-1652
    Abstract: We discovered a novel procaspase‐3 activator WF‐210. We demonstrated that WF‐210 has higher selection index. We found that WF‐210 could induce tumor cell apoptosis through activate procaspase‐3. WF‐210 or PAC‐1 induced apoptosis by promoting proteasome‐dependent degradation of IAPs. WF‐210 showed greater therapeutic effect in vivo compared with PAC‐1.
    Type of Medium: Online Resource
    ISSN: 1574-7891 , 1878-0261
    URL: Article
    DOI: 10.1016/j.molonc.2014.06.015
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2322586-5
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