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  • Hindawi Limited  (13)
  • Chen, Kang  (13)
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  • Hindawi Limited  (13)
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  • 1
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2019 ( 2019-11-21), p. 1-8
    Abstract: Objective . Using the AMSTAR tool, this study evaluated the quality of systematic reviews (SRs) that assessed the efficacy of bariatric surgery in diabetic patients. We aimed to identify studies that can be used as clinical references. Methods . Medline (via PubMed), EMBASE, Epistemonikos, Web of Science, Cochrane Library, CBM, CNKI, and Wanfang Data were systematically searched from inception to December 31, 2017. Two reviewers independently selected SRs and extracted data. Disagreements were solved by discussions or through consultation with a third reviewer. Reviewers extracted data (characteristics of included SRs, e.g., publication year, language, and number of authors) into the predefined tables in the Microsoft Excel 2013 sheet. Data were visualized using the forest plot in RevMan 5.3 software. Results . A total of 64 SRs were included. The average AMSTAR score was 7.4 ± 1.7 . AMSTAR scores of 7 ( n = 21 , 32.8%) and 8 ( n = 14 , 28.1%) were most common. The AMSTAR scores of SRs published before 2016 ( n = 46 , 71.9%) were compared with SRs published after 2016 ( n = 18 , 28.1%), and no significant differences were observed ( MD = − 0.79 , 95% confidence interval (CI) -1.65-0.07, P = 0.07 ). For SRs published in Chinese ( n = 17 , 26.6%) compared to those published in English ( n = 47 , 73.4%), the AMSTAR scores significantly differed ( MD = 0.21 , 95% CI (-0.55, 0.97), P = 0.59 ). For SRs published in China ( n = 33 , 51.6%) compared to those published outside of China ( n = 31 , 48.4%), significant differences in the AMSTAR scores were observed ( MD = 1.10 , 95% CI (0.29, 1.91), P = 0.008 ). For SRs with an author number ≤ 6 ( n = 31 , 48.4%) compared to SRs with authors ≥ 6 ( n = 33 , 51.6%), no significant differences were observed ( MD = − 0.36 , 95% CI (-1.22, 0.50), P = 0.41 ). For high-quality SRs published after 2016 ( n = 11 , 17.2%) compared to other SRs ( n = 53 , 82.8%), statistically significant differences were noted ( MD = 1.75 , 95% CI (1.01, 2.49), P 〈 0.00001 ). Conclusions . The number of SRs assessing the efficacy of bariatric surgery in diabetic patients is increasing by year, but only a small number meet the criteria to support guideline recommendations. Study protocols not being registered, grey literature not retrieved, incorporation of grey literature as exclusion criteria, and failure to evaluate publication bias and report a conflict of interest were the main causes of low AMSTAR scores.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2711897-6
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  • 2
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2019 ( 2019-01-27), p. 1-10
    Abstract: Background . The aim of this study is to explore the association between the number of childbirths and the progress of atherosclerosis among Chinese women with hypertension or diabetes. Methods . In total, 1159 Chinese parous women from a community longitudinal survey conducted in the communities of Shijingshan district, Beijing, China, were included in our study. They were divided into three groups according to the number of childbirths, and the change in pulse wave velocity (PWV) was as an indicator of the progression of atherosclerosis because the increased PWV reflected the more serious atherosclerosis. After 3 years, we conducted follow-up visits to the subjects. Logistical regression analyses were applied to investigate the relationship between the number of childbirths and the progression of atherosclerotic stiffness and a stratification analysis was performed for history of hypertension and diabetes. Results . After 3-year follow-up, among women with diabetes, the OR of women with 2 childbirths was significant [3.5 (95% confidence interval 1.5, 7.9)] in model I, [3.1 (95% confidence interval 1.3, 7.2)] in model II, and the OR of women with ≥3 childbirths was significant [4.4 (95% confidence interval 1.3, 14.5)] in model I, [4.1 (95% confidence interval 1.2, 14.3)] in model II. Among women with hypertension, the risk of the progress of atherosclerosis was not significant. Conclusion . The increasing number of childbirths is associated with the progression of atherosclerotic stiffness among Chinese women with diabetes, independent of a variety of confounding factors.
    Type of Medium: Online Resource
    ISSN: 1687-8337 , 1687-8345
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2502951-4
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  • 3
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2019 ( 2019-03-21), p. 1-12
    Abstract: Background . Physical activity is effective in preventing chronic diseases. However, the impact of different durations of exercise on human health is unknown, especially among people with diabetes or prediabetes. Objective . To explore the relationship between high MET hours per week and the change in glomerular filtration rate (eGFR) in the total population and different subgroups. Methods . A total of 43767 individuals from eight provinces, in China, were recruited. Logistic analysis was used to investigate the association. Participants were divided into 3 groups based on MET hours per week. The primary outcome was an eGFR ≤ 90   mL / min / 1.73   m 2 . Results . The average eGFR was 100.10 (92.43-106.43) mL/min/1.73 2 . Logistic regression analysis revealed that more than 7.5 MET hours per week (equivalent to more than 150 minutes of moderate-intensity of exercise) was associated with the higher risk of the decreased eGFR even after adjusting for confounding factors (7.5 to 〈 21: OR = 1.18 , 95% CI [1.09, 1.29]; ≥21: OR = 1.12 , 95% CI [1.05, 1.19], p for trend: 0.0047). After adjusting for confounding factors, in stratified analyses, there still existed a significant relationship among participants aged from 55 to less than 65 years, but not among participants younger than 55 or older than 65 years. Similarly, there existed a positive association between high MET hours per week and the decreased eGFR in participants without diabetes and prediabetes, but not in participants with diabetes or prediabetes, and the interactions of age and diabetic states were found. However, there was no significant difference in women or men. Conclusions . More than 7.5 MET hours per week (equivalent to more than 150 minutes per week or 60 minutes per day of moderate-intensity exercise) was associated with decreased eGFR among participants aged from 55 to less than 65 years and participants without diabetes and prediabetes, but not among participants aged younger than 55 years and older than 65 years and participants with diabetes or prediabetes. The importance of planning individualized physical activities is highlighted.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2711897-6
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  • 4
    In: International Journal of Clinical Practice, Hindawi Limited, Vol. 73, No. 3 ( 2019-03), p. e13279-
    Type of Medium: Online Resource
    ISSN: 1368-5031 , 1742-1241
    URL: Issue
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2135320-7
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  • 5
    Online Resource
    Online Resource
    Hindawi Limited ; 2021
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2021 ( 2021-10-21), p. 1-10
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2021 ( 2021-10-21), p. 1-10
    Abstract: Objective. Pneumonia due to hypervirulent Klebsiella pneumoniae (hvKP) is a high-risk subtype of pneumonia with high mortality and disability rates. An in-depth understanding of hvKP’s pathogenic process and mechanism of action is the focus of achieving early disease diagnosis and early symptomatic treatment. This study conducted a preliminary analysis on the influence of lncRNA NKILA (NKILA) on hvKP, aiming at providing a new approach to the diagnosis and treatment of hvKP and laying a reliable foundation for subsequent NKILA-related studies. Methods. Selected from our hospital from October 2016 to February 2018, 67 patients who were examined for the pathogenic microorganisms of alveolar lavage fluid were selected as the research subjects. Among them, 29 were diagnosed as hvKP (research group), and the other 38 had no pathogenic bacteria (control group). Serum and bronchoalveolar lavage fluid (BALF) NKILA and inflammatory factors were detected, and the clinical significance of NKILA was analyzed. In addition, neutrophils from research group were extracted and NKILA expression was increased to observe the alterations in cell apoptosis, respiratory burst intensity, and NF-kappa B inhibitor alpha (NF-κB) p65 protein. Results. Serum and BALF levels of NKILA and inflammatory factors were higher in research group than in control group, and NKILA decreased in both cohorts after treatment ( P 〈 0.05 ). NKILA had an excellent predictive effect on the occurrence of hvKP ( P 〈 0.001 ) and was positively correlated with inflammatory factors ( P 〈 0.05 ). Prognostic follow-up revealed that NKILA also had a good predictive value for death in hvKP patients ( P 〈 0.05 ), and increased posttreatment levels predicted an increased risk of death ( P 〈 0.05 ). In vitro, increased NKILA hindered the delayed apoptosis rate, decreased respiratory burst intensity of hvKP neutrophils, and activated NF-κB p65 protein ( P 〈 0.05 ). Conclusion. With an elevated expression profile in hvKP, NKILA can induce the delayed apoptosis of neutrophils, enhance the ability of releasing inflammatory mediators, and promote the progression of hvKP via activating NF-κB p65.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2148302-4
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  • 6
    Online Resource
    Online Resource
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-09-23), p. 1-12
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-09-23), p. 1-12
    Abstract: Background . Citri Sarcodactylis Fructus (CSF) is widely used as folk medicine in traditional Chinese medicine (TCM). The dried and steam-processed CSF (SCSF) has been employed for harmonizing the stomach over thousands of years under the guidelines of TCM theory. However, little is known about the differences in chemical compositions between CSF and SCSF. Moreover, the gastroprotective effects of CSF and SCSF on ethanol-induced gastric mucosal injuries in rats have yet to be investigated. Consequently, the present study aimed to investigate the chemical differences and gastroprotective effects of CSF and SCSF, providing some experimental framework for the development of CSF and SCSF. Methods . The chemical compositions of CSF and SCSF extracts were determined using an ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometer (UPLC-Q-TOF-MS), and their gastroprotective effects of different doses were assessed in rats with ethanol-induced gastric injuries on the levels of oxidative stress and inflammatory cytokines. Results . A total of 42 components were identified in CSF and SCSF, and most of them were flavonoids, limonoids, coumarins, and glycosides. There were no differences in the compositions between CSF and SCSF, but the relative contents of the components were different. Among them, nine screened compounds were considered as potential discriminating markers responsible for the differences between CSF and SCSF. Besides, pretreatments with CSF and SCSF markedly improved the gastric mucosal injuries in rats for their antioxidant and anti-inflammatory properties. And SCSF exhibited a better gastroprotective effect than CSF. Conclusion . The compositions of CSF were unchanged after steam-processing, while the relative contents of their components were changed. These changes may be the major reasons for the differentiation of their efficacies. In addition, CSF and SCSF could alleviate ethanol-induced gastric mucosal injury through the enhancement of antioxidant and anti-inflammatory activities. SCSF exhibited a better gastroprotective effect than CSF, which emphasized the necessity of steam processing.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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  • 7
    Online Resource
    Online Resource
    Hindawi Limited ; 2021
    In:  Journal of Advanced Transportation Vol. 2021 ( 2021-3-22), p. 1-19
    In: Journal of Advanced Transportation, Hindawi Limited, Vol. 2021 ( 2021-3-22), p. 1-19
    Abstract: The quantity of electrical coal transported through the tramp shipping network is increasing due to the high demands. This trend has increased the scheduling difficulty combined with the underdevelopment of the private thermal power plant port. The high coal consumption and low port storage capacity requires the scheduling of the tramp ship to be on a strict time window to ensure the continuous operation of the thermal power plant. The low port unloading capacity often leads to the port congestion and delay of the unloading operation. This paper develops a mixed-integer-programming model for the optimization of the tramp ship scheduling to reduce the total operation cost, including the transportation cost and the unloading waiting cost, and the branch-and-price algorithm is adopted to solve this large-scale model. The model and algorithm are tested with historical operation data from the thermal power plant in the southern coastal areas of China. The optimized scheme significantly reduces the total operation cost by reducing the unloading waiting time and the number of active vessels in certain periods. The results also demonstrate the algorithm improvement in the aspects of the optimization quality and efficiency comparing with the heuristic solution.
    Type of Medium: Online Resource
    ISSN: 2042-3195 , 0197-6729
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2553327-7
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  • 8
    Online Resource
    Online Resource
    Hindawi Limited ; 2017
    In:  Computational and Mathematical Methods in Medicine Vol. 2017 ( 2017), p. 1-9
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2017 ( 2017), p. 1-9
    Abstract: Proximal humeral fractures are common and most challenging, due to the complexity of the glenohumeral joint, especially in the geriatric population with impacted fractures, that the development of implants continues because currently the problems with their fixation are not solved. Pre-, intra-, and postoperative assessments are crucial in management of those patients. Finite element analysis, as one of the valuable tools, has been implemented as an effective and noninvasive method to analyze proximal humeral fractures, providing solid evidence for management of troublesome patients. However, no review article about the applications and effects of finite element analysis in assessing proximal humeral fractures has been reported yet. This review article summarized the applications, contribution, and clinical significance of finite element analysis in assessing proximal humeral fractures. Furthermore, the limitations of finite element analysis, the difficulties of more realistic simulation, and the validation and also the creation of validated FE models were discussed. We concluded that although some advancements in proximal humeral fractures researches have been made by using finite element analysis, utility of this powerful tool for routine clinical management and adequate simulation requires more state-of-the-art studies to provide evidence and bases.
    Type of Medium: Online Resource
    ISSN: 1748-670X , 1748-6718
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2256917-0
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  • 9
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2020 ( 2020-02-29), p. 1-14
    Abstract: Aims . To investigate the effect of preoperative HbA1c levels on the postoperative outcomes of coronary artery disease surgery in diabetic and nondiabetic patients. Methods and Results . The MEDLINE (via PubMed), Cochrane Library, Web of Science, Embase, Wanfang Data, China National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) databases were used to search the effects of different preoperative HbA1c levels on the postoperative outcomes of coronary artery disease surgical treatment in diabetic and nondiabetic patients from inception to December 2018. Two review authors worked in an independent and duplicate manner to select eligible studies, extract data, and assess the risk of bias of the included studies. We used a meta-analysis to synthesize data and analyze subgroups, sensitivity, and publication bias as well as the GRADE methodology if appropriate. The literature search retrieved 886 records initially, and 23 cohort studies were included in the meta-analysis. In this meta-analysis, we found that there was a reduced incidence of surgical site infections ( OR = 2.94 , 95% CI 2.18-3.98), renal failure events ( OR = 1.63 , 95% CI 1.13-2.33), and myocardial infarction events ( OR = 1.69 , 95% CI 1.16-2.47), as well as a shortened hospital stay ( MD = 1.08 , 95% CI 0.46-1.71), in diabetic patients after coronary artery disease surgical treatment with lower preoperative HbA1c levels. For nondiabetic patients, a higher preoperative HbA1c level resulted in an increase in the incidence of mortality ( OR = 2.23 , 95% CI 1.01-4.90) and renal failure ( OR = 2.33 , 95% CI 1.32-4.12). No significant difference was found between higher and lower preoperative HbA1c levels in the incidence of mortality ( OR = 1.06 , 95% CI 0.88-1.26), stroke ( OR = 1.49 , 95% CI 0.94-2.37), or atrial fibrillation ( OR = 0.94 , 95% CI 0.67-1.33); the length of ICU stay ( MD = 0.20 , 95% CI -0.14-0.55); or sepsis incidence ( OR = 2.49 , 95% CI 0.99-6.25) for diabetic patients or for myocardial infarction events ( OR = 1.32 , 95% CI 0.27-6.31) or atrial fibrillation events ( OR = 0.99 , 95% CI 0.74-1.33) for nondiabetic patients. The certainty of evidence was judged to be moderate or low. Conclusion . This meta-analysis showed that higher preoperative HbA1c levels may potentially increase the risk of surgical site infections, renal failure, and myocardial infarction and reduce the length of hospital stay in diabetic subjects after coronary artery disease surgical treatment and increase the risk of mortality and renal failure in nondiabetic patients. However, there was great inconsistency in defining higher preoperative HbA1c levels in the studies included; we still need high-quality RCTs with a sufficiently large sample size to further investigate this issue in the future. This trial is registered with CRD42019121531 .
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2711897-6
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  • 10
    In: Journal of Oncology, Hindawi Limited, Vol. 2022 ( 2022-9-28), p. 1-16
    Abstract: Background. Transarterial chemoembolization (TACE) is a first-line treatment for patients with unresectable hepatocellular carcinoma (HCC). Owing to differences in its efficacy across individuals, determining the indicators of patient response to TACE and finding approaches to reversing nonresponse thereto are necessary. Methods. Transcriptome data were obtained from the GSE104580 dataset, in which patients were marked as having TACE response or nonresponse. We identified differentially expressed genes (DEGs) and performed Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. We screened genes with a prognostic value for TACE in the HIF-1 signaling pathway by univariate regression analysis. By using least absolute shrinkage and selection operator (LASSO) Cox regression, we established a multigene signature in GSE14520, which we verified using a drug sensitivity test. The Connectivity Map (CMap) database was used to find potential drugs to reverse nonresponse to TACE. Results. We constructed a prognostic signature consisting of three genes (erythropoietin (EPO), heme oxygenase 1 (HMOX1), and serine protease inhibitor 1 (SERPINE1)) that we validated by drug sensitivity test. After dividing patients treated with TACE into high- and low-risk groups based on this new signature, we showed that overall survival (OS) of the high-risk group was significantly lower than that of the low-risk group and that the risk score was an independent predictor of OS in patients treated with TACE. Based on our CMap findings, we speculated that PD-184352, an inhibitor of mitogen-activated protein kinase (MEK), had potential as a drug treatment to reverse nonresponse to TACE. We confirmed this speculation by using PD-184352 in a cell promotion experiment in a TACE environment. Conclusion. We constructed a TACE-specific three-gene signature that could be used to predict HCC patients’ responses to and prognosis after TACE treatment. PD-184352 might have potential as a drug to improve TACE efficacy.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2461349-6
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