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  • 1
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. Publish Ahead of Print ( 2023-06-02)
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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  • 2
    In: Journal of Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 41, No. 9 ( 2023-09), p. 1411-1419
    Abstract: The brachial-ankle pulse-wave velocity (baPWV) is regarded as the gold standard in the evaluation of arterial stiffness. Its prognostic significance for major adverse cardiovascular events (MACE) has been demonstrated. However, the factors influencing the association between baPWV and MACE risk have not been determined. In this study, we investigated the association of baPWV and MACE risk and whether it is affected by the risk factors for different cardiovascular diseases (CVDs). Methods: This was a prospective cohort study that initially enrolled 6850 participants from 12 communities in Beijing. The participants were divided into three subgroups according to their baPWV values. The primary outcome was the first occurrence of MACE, defined as hospitalization from cardiovascular diseases, first occurrence of a nonfatal myocardial infarction, or nonfatal stroke. Cox proportional hazards regression and restricted cubic spline analyses were used to examine the association between baPWV and MACE. The effect of CVD risk factors on the relationship between baPWV and MACE was explored in subgroup analyses. Results: The final study population consisted of 5719 participants. During a median follow-up of 34.73 months, MACE occurred in 169 participants. The restricted cubic spline analysis indicated a positive linear relationship between baPWV and MACE risk. After adjustment for cardiovascular risk factors, the hazard ratio (HR) for MACE risk per SD increase in baPWV was 1.272 [95% confidence interval (CI): 1.149–1.407, P   〈  0.001], and the HR for MACE in the high-baPWV vs. the low-baPWV group was 1.965 (95% CI: 1.296–2.979, P  = 0.001). Adding baPWV to the conventional cardiovascular risk factors significantly improved the model's prediction performance and the net reclassification (NRI) [NRI: 0.379 (95% CI: 0.072–0.710), P  = 0.025] in MACE discrimination. However, in the subgroup analysis, two CVD risk factors, stable coronary heart disease and hypertension, showed significant interaction effects ( P interaction both 〈 0.05). This result indicated that the effect of CVD risk factors must be taken into account when assessing the relationship between baPWV and MACE. Conclusion: baPWV is a potential marker to improve the identification of MACE risk in the general population. A positive linear correlation was firstly determined between baPWV and MACE risk, but it may not be valid in participants with stable coronary heart disease and hypertension.
    Type of Medium: Online Resource
    ISSN: 0263-6352 , 1473-5598
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2017684-3
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  • 3
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2019 ( 2019-11-21), p. 1-8
    Abstract: Objective . Using the AMSTAR tool, this study evaluated the quality of systematic reviews (SRs) that assessed the efficacy of bariatric surgery in diabetic patients. We aimed to identify studies that can be used as clinical references. Methods . Medline (via PubMed), EMBASE, Epistemonikos, Web of Science, Cochrane Library, CBM, CNKI, and Wanfang Data were systematically searched from inception to December 31, 2017. Two reviewers independently selected SRs and extracted data. Disagreements were solved by discussions or through consultation with a third reviewer. Reviewers extracted data (characteristics of included SRs, e.g., publication year, language, and number of authors) into the predefined tables in the Microsoft Excel 2013 sheet. Data were visualized using the forest plot in RevMan 5.3 software. Results . A total of 64 SRs were included. The average AMSTAR score was 7.4 ± 1.7 . AMSTAR scores of 7 ( n = 21 , 32.8%) and 8 ( n = 14 , 28.1%) were most common. The AMSTAR scores of SRs published before 2016 ( n = 46 , 71.9%) were compared with SRs published after 2016 ( n = 18 , 28.1%), and no significant differences were observed ( MD = − 0.79 , 95% confidence interval (CI) -1.65-0.07, P = 0.07 ). For SRs published in Chinese ( n = 17 , 26.6%) compared to those published in English ( n = 47 , 73.4%), the AMSTAR scores significantly differed ( MD = 0.21 , 95% CI (-0.55, 0.97), P = 0.59 ). For SRs published in China ( n = 33 , 51.6%) compared to those published outside of China ( n = 31 , 48.4%), significant differences in the AMSTAR scores were observed ( MD = 1.10 , 95% CI (0.29, 1.91), P = 0.008 ). For SRs with an author number ≤ 6 ( n = 31 , 48.4%) compared to SRs with authors ≥ 6 ( n = 33 , 51.6%), no significant differences were observed ( MD = − 0.36 , 95% CI (-1.22, 0.50), P = 0.41 ). For high-quality SRs published after 2016 ( n = 11 , 17.2%) compared to other SRs ( n = 53 , 82.8%), statistically significant differences were noted ( MD = 1.75 , 95% CI (1.01, 2.49), P 〈 0.00001 ). Conclusions . The number of SRs assessing the efficacy of bariatric surgery in diabetic patients is increasing by year, but only a small number meet the criteria to support guideline recommendations. Study protocols not being registered, grey literature not retrieved, incorporation of grey literature as exclusion criteria, and failure to evaluate publication bias and report a conflict of interest were the main causes of low AMSTAR scores.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2711897-6
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  • 4
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2019 ( 2019-01-27), p. 1-10
    Abstract: Background . The aim of this study is to explore the association between the number of childbirths and the progress of atherosclerosis among Chinese women with hypertension or diabetes. Methods . In total, 1159 Chinese parous women from a community longitudinal survey conducted in the communities of Shijingshan district, Beijing, China, were included in our study. They were divided into three groups according to the number of childbirths, and the change in pulse wave velocity (PWV) was as an indicator of the progression of atherosclerosis because the increased PWV reflected the more serious atherosclerosis. After 3 years, we conducted follow-up visits to the subjects. Logistical regression analyses were applied to investigate the relationship between the number of childbirths and the progression of atherosclerotic stiffness and a stratification analysis was performed for history of hypertension and diabetes. Results . After 3-year follow-up, among women with diabetes, the OR of women with 2 childbirths was significant [3.5 (95% confidence interval 1.5, 7.9)] in model I, [3.1 (95% confidence interval 1.3, 7.2)] in model II, and the OR of women with ≥3 childbirths was significant [4.4 (95% confidence interval 1.3, 14.5)] in model I, [4.1 (95% confidence interval 1.2, 14.3)] in model II. Among women with hypertension, the risk of the progress of atherosclerosis was not significant. Conclusion . The increasing number of childbirths is associated with the progression of atherosclerotic stiffness among Chinese women with diabetes, independent of a variety of confounding factors.
    Type of Medium: Online Resource
    ISSN: 1687-8337 , 1687-8345
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2502951-4
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  • 5
    In: Diabetes/Metabolism Research and Reviews, Wiley, Vol. 37, No. 7 ( 2021-10)
    Abstract: Visceral obesity is a major health issue and is a risk factor for an atherogenic state. Visceral obesity has been reported to be a crucial link between albuminuria and cardiovascular diseases (CVD). This study attempted to explore the association between visceral obesity and albuminuria in prediabetic individuals. Methods This cross‐sectional study included 24871 prediabetic participants over 40 years of age from seven centres across China (REACTION study). The visceral adiposity index (VAI) was determined based on the measurements of anthropometric indices and lipid parameters. Increased albuminuria was defined as a urinary albumin‐creatinine ratio (UACR) ≥30 mg/g, indicating kidney damage. Propensity score matching was used to reduce bias, and a multiple logistic regression model was performed to evaluate the association between visceral obesity and albuminuria in the population with prediabetes. Results Participants with increased UACR exhibited increased VAI, age, blood pressure, triglycerides, poor glycaemic control, CVD events, and decreased estimated glomerular filtration rate (eGFR). Multiple logistic regression analysis demonstrated that VAI quartiles were positively associated with an increased risk of albuminuria (Q2: odds rate [OR]: 1.10, 95% confidence intervals [CI] 0.96–1.25; Q3: OR: 1.16, 95% CI 1.01–1.32; Q4: OR: 1.26, 95% CI 1.10–1.44, p for trend = 0.001). Stratified analysis revealed that the association of VAI level with increased albuminuria risk also occurred in people who were young, women, overweight or obese, with poor control of blood pressure, and eGFR ≥90 ml/min per 1.73 m 2 . Conclusions Visceral obesity assessed by VAI is significantly associated with increased UACR in a Chinese population with prediabetes.
    Type of Medium: Online Resource
    ISSN: 1520-7552 , 1520-7560
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2001565-3
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  • 6
    In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Informa UK Limited, Vol. Volume 14 ( 2021-05), p. 2415-2425
    Type of Medium: Online Resource
    ISSN: 1178-7007
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2494854-8
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  • 7
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2022
    In:  Hormone and Metabolic Research Vol. 54, No. 03 ( 2022-03), p. 145-152
    In: Hormone and Metabolic Research, Georg Thieme Verlag KG, Vol. 54, No. 03 ( 2022-03), p. 145-152
    Abstract: Interferon (IFN) is a broad-spectrum antiviral agent that activates cell surface receptors and causes cells to produce antiviral proteins, inhibiting viral replication. Interferon use has long been associated with diabetes. The PubMed database was searched for articles related to diabetes and interferon from March 30, 2020. Patients were divided into type 1 diabetes group and type 2 diabetes group. We reviewed the relevant literature to compare interferon-associated T1D and interferon-associated T2D differences. Interferon treatment shortened the incubation period of T2D and changed the original T2D to T1D. The onset of interferon-associated T1D required longer periods of IFN treatment than interferon-associated T2D, and the interferon-associated T1D group had higher GADA positive rates, lower BMI, lower fasting blood glucose, and greater insulin dependence (p 〈 0.05). More patients in the T1D group were positive for HLA-DRB1*04, DRB1*03, DRB1*09, DRB1*14, HLA-DQB1*04, HLA-DQB1*02, HLA-DQB1*03, and HLA-DQB1*05. The combined detection of GAD antibodies and HLA alleles may be an effective method to predict the incidence of T1D after IFN treatment.
    Type of Medium: Online Resource
    ISSN: 0018-5043 , 1439-4286
    RVK:
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
    detail.hit.zdb_id: 2056576-8
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  • 8
    In: Journal of Diabetes, Wiley, Vol. 13, No. 6 ( 2021-06), p. 494-505
    Abstract: 有多项研究表明; 非酒精性脂肪肝(NAFLD)与心血管疾病(CVD)有关。低水平蛋白尿(LLA)的排泄随着CVD患病率的升高而增加。但是; 少有研究探索NAFLD和LLA之间的相关性。 方法 这项横断面研究包括31 147名中国成年人(7664名男性和23 483名女性)。由尿白蛋白与肌酐之比(UACR)确定白蛋白尿的“正常”水平为低于30 mg / g。 LLA被定义为“正常”蛋白尿范围内的较高水平(5.54 mg / g 〈 LLA≤29.9mg / g)。NAFLD的定义为脂肪肝指数(FLI)≥60。FLI使用Bedogni方程计算。 结果 通过多变量线性回归分析; UACR与FLI之间存在正相关(非标准化β±SE:0.047±0.004; P 〈 0.001)。逻辑回归分析显示; NAFLD比值比(OR)在调整混杂因素的模型1‐4中与LLA显着相关(所有受试者:OR; 1.207; 95%CI; 1.098‐1.326;女性:OR; 1.43; 95%CI; 1.26‐1.63;所有P 〈 0.001);然而; 在调整混杂因素后; 我们没有发现男性之间有显著的OR。在分层分析中; 在24≤体重指数 〈 28 kg / m 2 、5.6≤ 空腹血糖 〈 7.0 mmol / L或7.8≤餐后血糖 〈 11.1 mmol / L以及60岁以下缺少中等强度运动的绝经后妇女中; NAFLD与LLA的相关性更为显著。 结论 在绝经后的妇女中; NAFLD和LLA之间存在显着的相关性; 且当这些妇女处于临界血糖值; 超重且缺少中等强度体育锻炼的状态下时; 两者的相关性更为明显。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2485432-3
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  • 9
    In: Journal of Diabetes, Wiley, Vol. 13, No. 8 ( 2021-08), p. 648-660
    Abstract: 在无心血管疾病(CVD)且尿蛋白正常的中国成年人群中, 关于低度白蛋白尿(低于微量白蛋白尿阈值)与心血管高危风险的相关性研究数据有限。 方法 本研究共纳入来自中国7个中心的32650名40岁以上社区人群。收集晨尿测尿微量白蛋白与肌酐的比值(UACR), 分别在男性和女性中进行数据分析, 并根据UACR水平将各性别人群分成四分位。采用Framingham风险评分(FRS)计算参与者未来10年罹患冠心病(CHD)的风险, FRS ≥ 20%者被定义为未来10年患冠心病的风险为高危。建立Logistic回归模型, 分析低度白蛋白尿与未来10年冠心病高危风险的相关性。 结果 在男性和女性中, 冠心病高危因素如糖尿病、高血压和血脂异常的患病率随着UACR水平的升高而显著增加。Logistic回归分析显示, 从男性UACR第二分位(UACR: 4.78 ~ 7.53 mg/g, OR = 1.21, 95% [CI]: 1.05‐1.40)、女性第三分位(UACR:9.13 ~ 15.04 mg/g, OR = 3.07, 95% CI: 1.75‐5.40)开始, 随着UACR的升高, 未来10年冠心病高危风险的比值比(OR)明显增加。分层分析显示, 在老年、超重或肥胖、无糖尿病和无高血压的男性以及老年、超重或肥胖、无糖尿病和有高血压的女性中, 这种相关性最为显著。 结论 在无心血管疾病病史且尿蛋白正常的中国成年人群中, 低度白蛋白尿与未来10年冠心病高危风险显著相关。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2485432-3
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  • 10
    In: Cardiovascular Diabetology, Springer Science and Business Media LLC, Vol. 19, No. 1 ( 2020-12)
    Abstract: Both lipid and glucose abnormalities are associated with hypertension (HTN). However, it is unclear whether the triglyceride-glucose (TyG) index is associated with HTN. Therefore the aim of this study is to investigate the association of the TyG index and HTN and to compare the discriminative power of the TyG index, lipid, glycemic parameters for the risk of HTN in elderly individuals. Methods The present study was nested in a longitudinal (REACTION) study from May 2011 to December 2011, which was designed to demonstrate the association of abnormal glucose metabolism with the risk of cancer in the Chinese population. In total, 47,808 participants were recruited in this cross-sectional study. The TyG index was divided into five groups: the  〈  20% group, the 20–39% group, the 40–59% group, the 60–79% group and the ≥ 80% group, according to quintile division of the subjects. Three multivariate logistic regression models were used to evaluate the association between the TyG vs. lipid parameters, glycemic parameters and HTN. Results Multivariate logistic regression analysis shows that compared with lipid and glycemic parameters, the TyG index remains significantly associated with HTN in either total subjects or subjects separated into men and women (odds ratio (OR) 1.33, 95% confidence interval (CI) 1.18–1.51, p  〈  0.0001 in total subjects; OR 1.39, 95% CI 1.11–1.74, p = 0.0042 in men; OR 1.28, 95% CI 1.11–1.49, p = 0.0010 in women). In a stratified analysis, an elevated TyG index is significantly associated with HTN in the subgroup of the oldest age (≥ 65) (OR 1.67, 95% CI 1.30–2.14, p  〈  0.0001), as well as with obesity (Body mass index (BMI) ≥ 28 kg/m 2 ) (OR 1.85, 95% CI 1.29–2.66, p = 0.0009) or lower estimated glomerular filtration rate (eGFR) ( 〈  90 mL/(min·1.73 m 2 )) (OR 1.72, 95% CI 1.33–2.21, p  〈  0.0001). Conclusion The TyG index is significantly associated with HTN and shows the superior discriminative ability for HTN compared with lipid and glycemic parameters in the Chinese elderly population.
    Type of Medium: Online Resource
    ISSN: 1475-2840
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2093769-6
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