In:
Asia-Pacific Psychiatry, Wiley, Vol. 9, No. 3 ( 2017-09)
Abstract:
The aim of the study was to explore the possible role of the 5‐HT 2A ‐1438G/A polymorphism in the susceptibility to anorexia nervosa (AN) in the Chinese Han population. Methods The ‐1438G/A polymorphism of 249 female AN patients, 228 matched healthy controls, and 198 trios was genotyped using SNaP shot assay. Psychopathological traits of eating‐disordered behaviors in AN subjects were examined using the Chinese version of the Eating Disorder Examination Questionnaire. Results Neither the case‐control analysis nor the transmission disequilibrium test revealed significant associations between the ‐1438G/A polymorphism and AN ( P 〉 .05). However, AA homozygote patients with AN had lower weight and shape concern scores of the EDE‐Q6.0 than those of GA heterozygotes ( P 〈 .05). Discussion Our findings suggested that female AN patients with 5‐HT 2A −1438AA genotype may be characterized by less severe eating‐disordered psychopathological traits in the Chinese Han population.
Type of Medium:
Online Resource
ISSN:
1758-5864
,
1758-5872
DOI:
10.1111/appy.2017.9.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2506343-1
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