GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Wiley  (9)
  • Chen, Jian  (9)
  • 1
    Online Resource
    Online Resource
    Laparoscopic Glissonian pedicle versus hilar dissection approach hemihepatectomy: A prospective, randomized controlled trial
    Wiley ; 2022
    In:  Journal of Hepato-Biliary-Pancreatic Sciences Vol. 29, No. 6 ( 2022-06), p. 629-640
    Details
    In: Journal of Hepato-Biliary-Pancreatic Sciences, Wiley, Vol. 29, No. 6 ( 2022-06), p. 629-640
    Abstract: This over 7‐year case study is the first to compare the results of laparoscopic Glissonian pedicle approach hemihepatectomy (LGAH) and laparoscopic hilar dissection approach hemihepatectomy (LHAH) in a randomized controlled trial (RCT). Methods Patients who had undergone laparoscopic hemihepatectomy, either LGAH or LHAH, between March 2012 and December 2019 at our center were prospectively enrolled and assigned to the LGAH or LHAH group. Both groups were stratified and compared, and the preoperative and follow‐up outcomes were analyzed. The primary endpoint was total operative time. Results The groups were equally matched for age, sex, HBsAg, Child‐Pugh class, benign disease, malignancy, liver cirrhosis, tumor diameter and type of resection. Ninety‐six patients had undergone LGAH and 94 had undergone LHAH. No preoperative death occurred in the two groups. LGAH did not enhance the postoperative overall complication rates ( P  = .465) or intraoperative blood loss ( P  = .535) compared with LHAH. However, the overall operative time ( P  = .014) and hilar dissection time ( P  = .000) were significantly shorter in the LGAH group than in the LHAH group. No significant differences were found between the groups regarding the 1‐year ( P  = .384), 3‐year ( P  = .332), and 5‐year overall survival rates ( P  = .662) or 1‐year ( P  = .856), 3‐year ( P  = .348), and 5‐year disease‐free survival rates ( P  = .573). Conclusions LGAH and LHAH are both effective procedures for treating the hilar structures in selected patients. LGAH has advantages over LHAH in reducing total operation time under the condition where both procedures can be used. LGAH for selected patients is worthy of promotion owing to its simplicity and convenience. Registration number: NCT01567631 ( http://www.clinicaltrials.gov ).
    Type of Medium: Online Resource
    ISSN: 1868-6974 , 1868-6982
    URL: Issue
    URL: Article
    DOI: 10.1002/jhbp.v29.6
    DOI: 10.1002/jhbp.1129
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2536390-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Hybrid Double Perovskite Derived Halides Based on Bi and Alkali Metals (K, Rb): Diverse Structures, Tunable Optical Properties and Second Harmonic Generation Responses
    Wiley ; 2023
    In:  Angewandte Chemie Vol. 135, No. 35 ( 2023-08-28)
    Details
    In: Angewandte Chemie, Wiley, Vol. 135, No. 35 ( 2023-08-28)
    Abstract: Double perovskites (DP) have attracted extensive attention due to their rich structures and wide application prospects in the field of optoelectronics. Here, we report 15 new Bi‐based double perovskite derived halides with the general formula of A 2 B Bi X 6 ( A =organic cationic ligand, B =K or Rb, X =Br or I). These materials are synthesized using organic ligands to coordinate with metal ions with a sp 3 oxygen, and diverse structure types have been obtained with distinct dimensionalities and connectivity modes. The optical band gaps of these phases can be tuned by changing the halide, the organic ligand and the alkali metal, varying from 2.0 to 2.9 eV. The bromide phases exhibit increasing photoluminescence (PL) intensity with decreasing temperature, while the PL intensity of iodide phases changes nonmonotonically with temperature. Because the majority of these phases are non‐centrosymmetric, second harmonic generation (SHG) responses are also measured for selected non‐centrosymmetric materials, showing different particle‐size‐dependent trends. Our findings give rise to a series of new structural types to the DP family, and provide a powerful synthetic handle for symmetry breaking.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v135.35
    DOI: 10.1002/ange.202307646
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Ruthenium‐Catalyzed meta ‐Selective C−H Nitration of Biologically Important Aryltetrazoles
    Wiley ; 2020
    In:  Advanced Synthesis & Catalysis Vol. 362, No. 14 ( 2020-07-29), p. 2984-2989
    Details
    In: Advanced Synthesis & Catalysis, Wiley, Vol. 362, No. 14 ( 2020-07-29), p. 2984-2989
    Abstract: The first example of tetrazole‐directed meta ‐selective C−H nitration is described. This transformation provided a straightforward approach for the synthesis of biologically important m ‐nitroaryltetrazoles in moderate to excellent yields with good functional group compatibility. In addition, new metallo‐β‐lactamase inhibitors were obtained by further transformation of the synthesized m ‐nitroaryltetrazoles. magnified image
    Type of Medium: Online Resource
    ISSN: 1615-4150 , 1615-4169
    URL: Issue
    URL: Article
    DOI: 10.1002/adsc.v362.14
    DOI: 10.1002/adsc.202000475
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2041384-1
    detail.hit.zdb_id: 2033084-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Oxidation of organoarsenicals and antimonite by a novel flavin monooxygenase widely present in soil bacteria
    Wiley ; 2022
    In:  Environmental Microbiology Vol. 24, No. 2 ( 2022-02), p. 752-761
    Details
    In: Environmental Microbiology, Wiley, Vol. 24, No. 2 ( 2022-02), p. 752-761
    Abstract: Arsenic can be biomethylated to form a variety of organic arsenicals differing in toxicity and environmental mobility. Trivalent methylarsenite (MAs(III)) produced in the methylation process is more toxic than inorganic arsenite (As(III)). MAs(III) also serves as a primitive antibiotic and, consequently, some environmental microorganisms have evolved mechanisms to detoxify MAs(III). However, the mechanisms of MAs(III) detoxification are not well understood. In this study, we identified an arsenic resistance ( ars ) operon consisting of three genes, arsRVK , that contribute to MAs(III) resistance in Ensifer adhaerens ST2. ArsV is annotated as an NADPH‐dependent flavin monooxygenase with unknown function. Expression of arsV in the arsenic hypersensitive Escherichia coli strain AW3110 Δars conferred resistance to MAs(III) and the ability to oxidize MAs(III) to MAs(V). In the presence of NADPH and either FAD or FMN, purified ArsV protein was able to oxidize both MAs(III) to MAs(V) and Sb(III) to Sb(V). Genes with arsV ‐like sequences are widely present in soils and environmental bacteria. Metagenomic analysis of five paddy soils showed the abundance of arsV ‐like sequences of 0.12–0.25 ppm. These results demonstrate that ArsV is a novel enzyme for the detoxification of MAs(III) and Sb(III) and the genes encoding ArsV are widely present in soil bacteria.
    Type of Medium: Online Resource
    ISSN: 1462-2912 , 1462-2920
    URL: Issue
    URL: Article
    DOI: 10.1111/emi.v24.2
    DOI: 10.1111/1462-2920.15488
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2020213-1
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Hybrid Double Perovskite Derived Halides Based on Bi and Alkali Metals (K, Rb): Diverse Structures, Tunable Optical Properties and Second Harmonic Generation Responses
    Wiley ; 2023
    In:  Angewandte Chemie International Edition Vol. 62, No. 35 ( 2023-08-28)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 62, No. 35 ( 2023-08-28)
    Abstract: Double perovskites (DP) have attracted extensive attention due to their rich structures and wide application prospects in the field of optoelectronics. Here, we report 15 new Bi‐based double perovskite derived halides with the general formula of A 2 B Bi X 6 ( A =organic cationic ligand, B =K or Rb, X =Br or I). These materials are synthesized using organic ligands to coordinate with metal ions with a sp 3 oxygen, and diverse structure types have been obtained with distinct dimensionalities and connectivity modes. The optical band gaps of these phases can be tuned by changing the halide, the organic ligand and the alkali metal, varying from 2.0 to 2.9 eV. The bromide phases exhibit increasing photoluminescence (PL) intensity with decreasing temperature, while the PL intensity of iodide phases changes nonmonotonically with temperature. Because the majority of these phases are non‐centrosymmetric, second harmonic generation (SHG) responses are also measured for selected non‐centrosymmetric materials, showing different particle‐size‐dependent trends. Our findings give rise to a series of new structural types to the DP family, and provide a powerful synthetic handle for symmetry breaking.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v62.35
    DOI: 10.1002/anie.202307646
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Apicidin attenuates memory deficits by reducing the Aβ load in APP / PS1 mice
    Wiley ; 2023
    In:  CNS Neuroscience & Therapeutics Vol. 29, No. 5 ( 2023-05), p. 1300-1311
    Details
    In: CNS Neuroscience & Therapeutics, Wiley, Vol. 29, No. 5 ( 2023-05), p. 1300-1311
    Abstract: Amyloid beta (Aβ) is an important pathological feature of Alzheimer's disease (AD). A disintegrin and metalloproteinase 10 (ADAM10) can reduce the production of toxic Aβ by activating the nonamyloidogenic pathway of amyloid precursor protein (APP). We previously found that apicidin, which is a histone deacetylase (HDAC) inhibitor, can promote the expression of ADAM10 and reduce the production of Aβ in vitro. This study was designed to determine the potential of apicidin treatment to reverse learning and memory impairments in an AD mouse model and the possible correlation of these effects with ADAM10. Methods Nine‐month‐old APP/PS1 mice and C57 mice received intraperitoneal injections of apicidin or vehicle for 2 months. At 11 months of age, we evaluated the memory performance of mice with Morris water maze (MWM) and context fear conditioning tests. The Aβ levels were assessed in mouse brain using the immunohistochemical method and ELISA. The expression of corresponding protein involved in proteolytic processing of APP and the phosphorylation of tau were assessed by Western blotting. Results Apicidin reversed the deficits of spatial reference memory and contextual fear memory, attenuated the formation of Aβ‐enriched plaques, and decreased the levels of soluble and insoluble Aβ40/42 in APP/PS1 mice. Moreover, apicidin significantly increased the expression of ADAM10, improved the level of sAPPα, and reduced the production of sAPPβ, but did not affect the levels of phosphorylated tau in APP/PS1 mice. Conclusion Apicidin significantly improves the AD symptoms of APP/PS1 mice by regulating the expression of ADAM10, which may contribute to decreasing the levels of Aβ rather than decreasing the phosphorylation of tau.
    Type of Medium: Online Resource
    ISSN: 1755-5930 , 1755-5949
    URL: Article
    DOI: 10.1111/cns.14102
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2423467-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP / PS1 mice
    Wiley ; 2023
    In:  Traffic Vol. 24, No. 1 ( 2023-01), p. 20-33
    Details
    In: Traffic, Wiley, Vol. 24, No. 1 ( 2023-01), p. 20-33
    Abstract: AP2S1 is the sigma 2 subunit of adaptor protein 2 (AP2) that is essential for endocytosis. In this study, we investigated the potential role of AP2S1 in intracellular processing of amyloid precursor protein (APP), which contributes to the pathogenesis of Alzheimer disease (AD) by generating the toxic β‐amyloid peptide (Aβ). We found that knockdown or overexpression of AP2S1 decreased or increased the protein levels of APP and Aβ in cells stably expressing human full‐length APP695, respectively. This effect was unrelated to endocytosis but involved lysosomal degradation. Morphological studies revealed that silencing of AP2S1 promoted the translocalization of APP from RAB9‐positive late endosomes (LE) to LAMP1‐positive lysosomes, which was paralleled by the enhanced LE‐lysosome fusion. In support, silencing of vacuolar protein sorting‐associated protein 41 (VPS41) that is implicated in LE‐lyso fusion prevented AP2S1‐mediated regulation of APP degradation and translocalization. In APP/PS1 mice, an animal model of AD, AAV‐mediated delivery of AP2S1 shRNA in the hippocampus significantly reduced the protein levels of APP and Aβ, with the concomitant APP translocalization, LE‐lyso fusion and the improved cognitive functions. Taken together, these data uncover a LE‐lyso fusion mechanism in APP degradation and suggest a novel role for AP2S1 in the pathophysiology of AD.
    Type of Medium: Online Resource
    ISSN: 1398-9219 , 1600-0854
    URL: Issue
    URL: Article
    DOI: 10.1111/tra.v24.1
    DOI: 10.1111/tra.12874
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020962-9
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression
    Wiley ; 2021
    In:  Journal of Neurochemistry Vol. 157, No. 4 ( 2021-05), p. 1351-1365
    Details
    In: Journal of Neurochemistry, Wiley, Vol. 157, No. 4 ( 2021-05), p. 1351-1365
    Abstract: Thioredoxin‐2 (TXN2) is a mitochondrial protein and represents one of the intrinsic antioxidant enzymes. It has long been recognized that mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of Alzheimer's disease (AD). We hypothesized that mitochondrial TXN2 might play a role in AD‐like pathology. In this study, we found that in SH‐SY5Y and HEK cells stably express full‐length human amyloid‐β precursor protein (HEK‐APP), TXN2 silencing or over‐expression selectively increased or decreased the transcription of beta‐site amyloid precursor protein cleaving enzyme 1 (BACE1), respectively, without altering the protein levels of others enzymes involved in the catalytic processing of APP. As a result, β‐amyloid protein (Aβ) levels were significantly decreased by TXN2. In addition, in cells treated with 3‐nitropropionic acid (3‐NP) that is known to increase reactive oxygen species (ROS) and promote mitochondrial dysfunction, TXN2 silencing resulted in further enhancement of BACE1 protein levels, suggesting a role of TXN2 in ROS removal. The downstream signaling might involve NFκB, as TXN2 reduced the phosphorylation of p65 and IκBα; and p65 knockdown significantly attenuated TXN2‐mediated regulation of BACE1. Concomitantly, the levels of cellular ROS, apoptosis‐related proteins and cell viability were altered by TXN2 silencing or over‐expression. In APPswe/PS1E9 mice, an animal model of AD, the cortical and hippocampal TXN2 protein levels were decreased at 12 months but not at 6 months, suggesting an age‐dependent decline. Collectively, TXN2 regulated BACE1 expression and amyloidogenesis via cellular ROS and NFκB signaling. TXN2 might serve as a potential target especially for early intervention of AD. image
    Type of Medium: Online Resource
    ISSN: 0022-3042 , 1471-4159
    URL: Issue
    URL: Article
    DOI: 10.1111/jnc.v157.4
    DOI: 10.1111/jnc.15184
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2020528-4
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Novel dinuclear and trinuclear ruthenium clusters derived from 2‐aryl‐substituted indenylphosphines via C─H bond cleavage
    Wiley ; 2017
    In:  Applied Organometallic Chemistry Vol. 31, No. 8 ( 2017-08)
    Details
    In: Applied Organometallic Chemistry, Wiley, Vol. 31, No. 8 ( 2017-08)
    Abstract: Treatment of Ru 3 (CO) 12 with an equivalent of (2‐phenyl‐1 H ‐inden‐3‐yl)dicyclohexylphosphine ( 1 ) and (2‐pyridyl‐1 H ‐inden‐1‐yl)dicyclohexylphosphine ( 4 ) in refluxing heptane gave the novel trinuclear ruthenium clusters (μ 3 ‐η 1 :η 2 :η 5 –2‐phenyl‐3‐Cy 2 PC 9 H 4 )Ru 3 (CO) 8 ( 1c ) and [μ 2 ‐η 1 –2‐(pyridin‐2‐yl)‐3‐Cy 2 PC 9 H 6 ]Ru 3 (CO) 9 ( 4a ), respectively, via C ─ H bond cleavage. (2‐Mesityl‐1 H ‐inden‐3‐yl)dicyclohexylphosphine ( 2 ) reacted with Ru 3 (CO) 12 in refluxing heptane to give the trinuclear ruthenium cluster [μ‐2‐mesityl‐(3‐Cy 2 PC 9 H 5 )](μ 2 ‐CO)Ru 3 (CO) 9 ( 2c ) via C ─ H bond cleavage and carbonyl insertion. 2‐(Anthracen‐9‐yl)‐1 H –inden‐3‐yldicyclohexylphosphine ( 3 ) reacted with Ru 3 (CO) 12 in refluxing heptane to give the dinuclear ruthenium cluster [μ 2 ‐η 3 :η 3 –2‐(anthracen‐9‐yl)‐3‐Cy 2 PC 9 H 6 ]Ru 2 (CO) 5 ( 3a ). The structures of 1c , 2c , 3a and 4a were fully characterized using IR and NMR spectroscopy, elemental analysis and single‐crystal X‐ray diffraction. These results suggest that the 2‐aryl substituent on the indenyl ring has a pronounced effect on the reaction and coordination modes of Ru 3 (CO) 12 .
    Type of Medium: Online Resource
    ISSN: 0268-2605 , 1099-0739
    URL: Issue
    URL: Article
    DOI: 10.1002/aoc.v31.8
    DOI: 10.1002/aoc.3670
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1480791-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...