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  • Chen, Hong  (6)
  • Comparative Studies. Non-European Languages/Literatures  (6)
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  • Comparative Studies. Non-European Languages/Literatures  (6)
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  • 1
    Online Resource
    Online Resource
    Transcranial cavitation localization by time difference of arrival algorithm using four sensors
    Acoustical Society of America (ASA) ; 2020
    In:  The Journal of the Acoustical Society of America Vol. 148, No. 4_Supplement ( 2020-10-01), p. 2560-2560
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 148, No. 4_Supplement ( 2020-10-01), p. 2560-2560
    Abstract: Cavitation is widely existing in focused ultrasound (FUS)-mediated therapies in the brain, such as FUS in combination with microbubble-induced blood-brain barrier disruption, nonthermal ablation, as well as transcranial histotripsy therapy. Accurately knowing the 3-D location of cavitation in real time can improve the treatment targeting accuracy and avoid off-target tissue damage. However, the skull induces strong phase and amplitude aberration to the cavitation signals and presents a significant challenge to the transcranial cavitation localization. Existing techniques for 3-D cavitation localization use hemispherical multi-element arrays combined with passive beamforming and adaptive skull-specific correction algorithm. However, these techniques require expensive equipment and treatment planning. Their time-consuming computations limit applications in real-time cavitation monitoring, which is critically needed to ensure the safety and efficacy of the FUS treatment. The object of this study was to investigate the feasibility of using a four-sensor network to transcranially locate the cavitation source in 3-D by time difference of arrival algorithm. The positional error of transcranial cavitation localization with the human skull along x, y, and z axes were 1.7 ± 1.2 mm, 1.6 ± 1.7 mm, and 4.1 ± 1.5 mm, respectively. For comparison, the positional error of without the human skull were 1.2 ± 1.8 mm, 0.9 ± 1.6 mm, and 3.1 ± 2.3 mm, respectively.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.5147104
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2020
    detail.hit.zdb_id: 1461063-2
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  • 2
    Online Resource
    Online Resource
    Affordable stereotactic-guided focused ultrasound device for tunable drug delivery to the mouse brain
    Acoustical Society of America (ASA) ; 2021
    In:  The Journal of the Acoustical Society of America Vol. 150, No. 4_Supplement ( 2021-10-01), p. A129-A129
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 150, No. 4_Supplement ( 2021-10-01), p. A129-A129
    Abstract: Focused ultrasound combined with microbubble (FUS+MB)-mediated blood brain barrier (BBB) opening is not only a promising technique for clinical applications but also a powerful tool for preclinical neuroscience and neuro-oncology research. However, existing FUS systems are expensive and lack the flexibility of modulating BBB opening volume, which prevents a broader research community from adopting the FUS+MB technique in preclinical studies. To address the challenge, we developed a low cost (∼$100), mini FUS transducer with the capability to modulate BBB opening size that can be readily integrated with a standard stereotaxic frame for mouse. Specifically, we manufactured in-house mini FUS transducers with three frequencies (1.5, 3.0, and 6.0 MHz), and quantified BBB opening and targeting accuracy at varying pressures (0.20 to 0.81 MPa). The volume of FUS+MB-induced BBB opening was evaluated using both contrast-enhanced MRI and Evans blue extravasation. Our results showed that we can achieve varying amount of Evans blue delivery and BBB opening size by modulating the transducer frequency and acoustic pressure. Additionally, the amount of Evans blue delivery and BBB opening had a significant linear correlation with the cavitation index (defined by the ratio between acoustic pressure and frequency). We believe that this stereotaxic-guided FUS system will lower the barrier for adopting the FUS technique in a broader research community.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0007864
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2021
    detail.hit.zdb_id: 1461063-2
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    Online Resource
  • 3
    Online Resource
    Online Resource
    C-mode passive cavitation images for predicting large volume FUS-mediated drug delivery outcome
    Acoustical Society of America (ASA) ; 2021
    In:  The Journal of the Acoustical Society of America Vol. 150, No. 4_Supplement ( 2021-10-01), p. A128-A128
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 150, No. 4_Supplement ( 2021-10-01), p. A128-A128
    Abstract: Passive cavitation detection has been commonly used to monitor focused ultrasound (FUS)-mediated blood-brain barrier disruption (FUS-BBBD). Previous research by our team has shown the feasibility to correlate passive cavitation imaging (PCI) with drug delivery outcome via FUS-BBBD at a single target. This study proposed to perform c-mode PCI for predicting the spatial distribution of aPD-L1 delivered by FUSBBBD. A single-element FUS transducer was used to perform sonication iteratively in a 3×3 grid at the whole brainstem of wild-type mice. PCI were acquired using an ultrasound imaging probe co-aligned with the FUS transducer. Reconstruction was performed to obtain c-mode PCI for the whole sonicated area in the plane normal to the PCI imaging plane (axial plane of FUS transducer). Fluorescence-labeled aPD-L1 was intravenously injected after FUS sonication and the delivery outcome was quantified using ex vivo fluorescence imaging. A high correlation (R2 = 0.79) was obtained between the fluorescence intensity and the cavitation dosage calculated from the c-mode PCI. No significant difference was found between 3dB area of the fluroescence images (6.93 ± 2.24mm2) and the 3 dB area of the c-mode PCI images (7.20 ± 0.74mm2). This study demonstrated that the c-mode PCI had the potential to predict drug delivery outcome by large volume FUS-BBBD.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0007861
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2021
    detail.hit.zdb_id: 1461063-2
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  • 4
    Online Resource
    Online Resource
    Reliable and safe blood–brain barrier opening by closed-loop feedback control of focused ultrasound
    Acoustical Society of America (ASA) ; 2021
    In:  The Journal of the Acoustical Society of America Vol. 150, No. 4_Supplement ( 2021-10-01), p. A30-A30
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 150, No. 4_Supplement ( 2021-10-01), p. A30-A30
    Abstract: Real-time cavitation monitoring and feedback controller is critical to safe and effective brain drug delivery by focused ultrasound (FUS)-mediated blood-brain barrier disruption (FUS-BBBD). However, existing controllers were either open-loop or using a generalized target cavitation level (TCL). This study aimed to develop a closed-loop feedback controller with TCL defined based on the baseline stable cavitation level (SCL) of each subject. A single-element FUS transducer with a coaxially aligned passive cavitation detector (PCD) was used. PCD signals were first acquired with “dummy” sonication to determine TCL defined to be 0.5, 1, 2, 3, or 4 dB above baseline SCL. A custom closed-loop feedback controller was developed to control SCL to be at each TCL. After sonication, wild-type mice were intravenously injected with Evans Blue (EB) to quantify FUS-BBBD using ex vivo fluorescence imaging. The fluorescence intensity of delivered EB increased in an average of 1.4-fold, 2.6-fold, and 3.9-fold at 1, 2, and 3dB respectively compared to the 0.5-dB group. No apparent hemorrhage was found in lower TCLs, and hemorrhage was consistently found in the 4-dB group. This study demonstrated that the individualized feedback controller achieved reliable and safe FUS-BBBD at selected TCL.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0007518
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2021
    detail.hit.zdb_id: 1461063-2
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  • 5
    Online Resource
    Online Resource
    Shaveless focused-ultrasound-induced blood-brain barrier opening in mice
    Acoustical Society of America (ASA) ; 2023
    In:  The Journal of the Acoustical Society of America Vol. 153, No. 3_supplement ( 2023-03-01), p. A140-A140
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 153, No. 3_supplement ( 2023-03-01), p. A140-A140
    Abstract: To demonstrate that focused ultrasound-induced blood-brain barrier opening (FUS-BBBO) in mice can be achieved without shaving hairs. We performed FUS-BBBO in mice by using oil as the coupling medium without shaving hairs. The hydrophobic nature of oil leads to a higher affinity to hair than water-based ultrasound gel. FUS-BBBO outcome was compared under three conditions: “oil + hairs,” “gel + hairs,” and “gel + no hairs.” T2-weighted, T1-weighted MRI, and fluorescence imaging of the ex vivo brain slices were performed to measure the quality of coupling and outcome of FUS-BBBO. Results showed that “oil + hairs” consistently achieved high-quality acoustic coupling without trapping air bubbles (Figures A & B). FUS-BBBO outcome was not significantly different between the “oil + hairs” group and the “gel + no hairs” group based on T1-weighted MRI (Figures C & D) and ex vivo fluorescence imaging (Figure E). The FUS-BBBO efficiencies for both the “oil + hairs” and “gel + no hairs” groups were significantly higher than the “gel + hairs” group. This study demonstrated that FUS-BBBO in mice could be achieved without shaving hairs. Oil provides a simple solution for achieving effective acoustic coupling for transcranial FUS procedures.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0018435
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2023
    detail.hit.zdb_id: 1461063-2
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    Online Resource
  • 6
    Online Resource
    Online Resource
    Dynamics of focused ultrasound-enhanced glymphatic transportation in the mouse brain
    Acoustical Society of America (ASA) ; 2023
    In:  The Journal of the Acoustical Society of America Vol. 153, No. 3_supplement ( 2023-03-01), p. A140-A140
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 153, No. 3_supplement ( 2023-03-01), p. A140-A140
    Abstract: The glymphatic system, a perivascular network in the brain, regulates the exchange of cerebrospinal fluid and interstitial fluid in the perivascular space. Focused ultrasound combined with microbubbles (FUSMB) has been recently shown feasible to manipulate the glymphatic transportation by enhancing the intranasal delivery of agents in the perivascular space. The objective of this study was to reveal the dynamics of FUSMB-enhanced agent transport in the glymphatic system. A ring-shaped FUS transducer was confocally aligned with an objective of a two-photon microscope (2PM). Fluorescently labeled albumin was administered to the mouse nose, where it transported along olfactory nerve and trigeminal nerve from nose to brain and then spread in perivascular space in the brain. FUS sonication was performed after intravenous injection of microbubbles. In vivo 2PM recorded the dynamics of agent transportation before, during, and after FUS sonication. Time-lapse recording showed that FUSMB enhanced the agent accumulation at the perivascular space. FUS significantly increased the accumulation of the agent in the perivascular space by 1.2-folds immediately after the sonication (p = 0.0325), and 1.6-folds at 5 min after the sonication (p  & lt; 0.0001). In conclusion, this study showed, for the first time, direct evidence of FUSMB-enhanced glymphatic transportation in the mouse brain.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0018432
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2023
    detail.hit.zdb_id: 1461063-2
    Location Call Number Limitation Availability
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    Online Resource
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