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  • 1
    In: Brazilian Journal of Pharmaceutical Sciences, FapUNIFESP (SciELO), Vol. 56 ( 2020)
    Type of Medium: Online Resource
    ISSN: 2175-9790
    Language: English
    Publisher: FapUNIFESP (SciELO)
    Publication Date: 2020
    detail.hit.zdb_id: 2685807-1
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2023
    In:  BMC Immunology Vol. 24, No. 1 ( 2023-12-06)
    In: BMC Immunology, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2023-12-06)
    Abstract: Screening of lysosome-related genes in sepsis patients to provide direction for lysosome-targeted therapy. Methods Peripheral blood samples were obtained from 22 patients diagnosed with sepsis and 10 normal controls for the purpose of RNA sequencing and subsequent analysis of differential gene expression. Concurrently, lysosome-related genes were acquired from the Gene Ontology database. The intersecting genes between the differential genes and lysosome-related genes were then subjected to PPI, GO and KEGG analyses. Core genes were identified through survival analysis, and their expression trends in different groups were determined using meta-analysis. Single-cell RNA sequencing was used to clarify the cellular localization of core genes. Results The intersection of 1328 sepsis-differential genes with 878 lysosome-related genes yielded 76 genes. PPI analysis showed that intersecting genes were mainly involved in Cellular process, Response to stimulus, Immune system process, Signal transduction, Lysosome. GO and KEGG analysis showed that intersecting genes were mainly involved in leukocyte mediated immunity, cell activation involved in immune response, lytic vacuole, lysosome. Survival analysis screened four genes positively correlated with sepsis prognosis, namely GNLY, GZMB, PRF1 and RASGRP1. The meta-analysis revealed that the expression levels of these four genes were significantly higher in the normal control group compared to the sepsis group, which aligns with the findings from RNA sequencing data. Furthermore, single-cell RNA sequencing demonstrated that T cells and NK cells exhibited high expression levels of GNLY, GZMB, PRF1, and RASGRP1. Conclusion GNLY, GZMB, PRF1, and RASGRP1, which are lysosome-related genes, are closely linked to the prognosis of sepsis and could potentially serve as novel research targets for sepsis, offering valuable insights for the development of lysosome-targeted therapy. The clinical trial registration number is ChiCTR1900021261, and the registration date is February 4, 2019.
    Type of Medium: Online Resource
    ISSN: 1471-2172
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2041500-X
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  • 3
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Circulation Research Vol. 129, No. Suppl_1 ( 2021-09-03)
    In: Circulation Research, Ovid Technologies (Wolters Kluwer Health), Vol. 129, No. Suppl_1 ( 2021-09-03)
    Abstract: Objectives: Maternal hypothyroidism (MH), a common clinical condition with a reported prevalence from 2.5% to 13%. MH could have an adverse effect on fetal cardiac development and adult heart function. However, there is a lack of systematic research for its effect on fetal and offspring’s development and cardiac function. This study aimed to determine the impact of MH on fetal and offspring’s organ structural and functional development at different gestation stages and during postnatal and puberty. Methods: MH model had been built through thyroidectomy (TX) with total thyroxine (TT4) under 1ng/dl after surgery. Pups from mice that underwent TX and Sham surgery were named THD (Deficient) and THN (Normal). Times of parturition and miscarriage from TX and Sham groups were recorded. Ultrasound was performed for fetuses and/or offspring to check the gestation, miscarriage, embryo arrest, development, malformation, and cardiac function. At different postnatal days, mice were euthanized for organ development evaluation. Result: TX mice had reduced parturition frequencies and smaller litter size but increased miscarriage frequency and malformed fetuses than the sham group. In addition, THD fetuses had smaller biparietal diameter (BPD) and abdominal circumference (AC) and significantly lower left ventricular ejection fraction (LVEF) on E14.5, but not at E18.5. Tei index, a parameter representing both systolic and diastolic cardiac function, was lower in THD fetuses than in THN fetuses at both E14.5 and E18.5. The cardiac systolic and diastolic function of female TX mice after a 9-month breeding period was also abnormal. The Postnatal T4 level was not significantly different between the two groups. On and after d21 after birth, THD mice had a higher heart weight/body weight ratio and lower LVEF still d21. Conclusion: MH impaired the development and cardiac function of the fetus and young adult. In addition, MH impaired the mother's fertility and depressed cardiac function.
    Type of Medium: Online Resource
    ISSN: 0009-7330 , 1524-4571
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 80100-8
    detail.hit.zdb_id: 1467838-X
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  • 4
    In: Remote Sensing, MDPI AG, Vol. 15, No. 13 ( 2023-06-30), p. 3367-
    Abstract: Extracting roads from remote sensing images is of significant importance for automatic road network updating, urban planning, and construction. However, various factors in complex scenes (e.g., high vegetation coverage occlusions) may lead to fragmentation in the extracted road networks and also affect the robustness of road extraction methods. This study proposes a multi-scale road extraction method with asymmetric generative adversarial learning (MS-AGAN). First, we design an asymmetric GAN with a multi-scale feature encoder to better utilize the context information in high-resolution remote sensing images (HRSIs). Atrous spatial pyramid pooling (ASPP) and feature fusion are integrated into the asymmetric encoder–decoder structure to avoid feature redundancy caused by multi-level cascading operations and enhance the generator network’s ability to extract fine-grained road information at the pixel level. Second, to maintain road connectivity, topologic features are considered in the pixel segmentation process. A linear structural similarity loss (LSSIM) is introduced into the loss function of MS-AGAN, which guides MS-AGAN to generate more accurate segmentation results. Finally, to fairly evaluate the performance of deep models under complex backgrounds, the Bayesian error rate (BER) is introduced into the field of road extraction for the first time. Experiments are conducted via Gaofen-2 (GF-2) high-resolution remote sensing images with high vegetation coverage in the Daxing District of Beijing, China, and the public DeepGlobe dataset. The performance of MS-AGAN is compared with a list of advanced models, including RCFSNet, CoANet, UNet, DeepLabV3+, and DiResNet. The final results show that (1) with respect to road extraction performance, the Recall, F1, and IoU values of MS-AGAN on the Daxing dataset are 2.17%, 0.04%, and 2.63% higher than the baselines. On DeepGlobe, the Recall, F1, and IoU of MS-AGAN improve by 1.12%, 0.42%, and 0.25%, respectively. (2) On road connectivity, the Conn index of MS-AGAN from the Daxing dataset is 46.39%, with an improvement of 0.62% over the baselines, and the Conn index of MS-AGAN on DeepGlobe is 70.08%, holding an improvement of 1.73% over CoANet. The quantitative and qualitative analyses both demonstrate the superiority of MS-AGAN in preserving road connectivity. (3) In particular, the BER of MS-AGAN is 20.86% over the Daxing dataset with a 0.22% decrease compared to the best baselines and 11.77% on DeepGlobe with a 0.85% decrease compared to the best baselines. The proposed MS-AGAN provides an efficient, cost-effective, and reliable method for the dynamic updating of road networks via HRSIs.
    Type of Medium: Online Resource
    ISSN: 2072-4292
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2513863-7
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  • 5
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2018
    In:  IEEE Access Vol. 6 ( 2018), p. 37403-37412
    In: IEEE Access, Institute of Electrical and Electronics Engineers (IEEE), Vol. 6 ( 2018), p. 37403-37412
    Type of Medium: Online Resource
    ISSN: 2169-3536
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018
    detail.hit.zdb_id: 2687964-5
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  • 6
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2024
    In:  Cardiovascular Ultrasound Vol. 22, No. 1 ( 2024-07-29)
    In: Cardiovascular Ultrasound, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2024-07-29)
    Abstract: Currently, no normal ultrasound data of the fetuses during the 20–40 gestation have been obtained for references of fetal growth and development. If such ultrasound data existed for prenatal diagnosis of possible diseases and abnormalities, neonates would be able to get timely treatment immediately after birth. This study was thus performed to obtain ultrasound parameters of normal fetuses during the 20–40 week gestation and the distribution of ultrasound parameters with the gestational age for references of detecting potential fetal diseases and abnormalities. Methods Normal fetuses without any abnormalities were enrolled, and the ultrasound parameters of the general biology, arteries, and aorta were measured and analyzed. Results 417 normal fetuses were enrolled. A significant ( P   〈  0.05) negative correlation with the gestational age was detected in the peak systolic velocity/peak diastolic velocity (S/D), pulsatility index (PI) and resistance index (RI) of the umbilical artery (UA). A relatively stable relationship with the gestational age was detected in the fetal weight%, S/D, PI and RI of the middle cerebral artery (MCA), peak systolic velocity (PSV) and velocity time integral (VTI) of the intra-abdominal UA, fetal heart to chest ratio, mitral valve (MV)- and tricuspid valve (TV)-E/A peak flow velocity, aortic isthmic Z-score and displacement, distance between the brachiocephalic artery-left common carotid artery (BA-LCCA) and LCCA-left subclavian artery (LSA), Z-score of aorta, ascending aorta (AAO), pulmonary artery (PA), main pulmonary artery (MPA), and descending aorta (DAO). A significant ( P   〈  0.05) positive correlation with the gestational age was detected in the fetal biological data, MCA PSV and VTI, free-UA PSV and VTI and cardio-thoracic ratio, cardiac parameters, ductus arteriosus (DA) and isthmus diameter, aortic parameters, PA and MPA diameter, MPA PSV and VTI, isthmus flow volume and velocity and PA flow volume, DA and BA parameters, and LCCA and LSA parameters (flow volume, PSV, and VTI). Conclusion A certain correlation and distribution trend is detected in the ultrasound parameters of normal fetuses, and the ratios among different parameters remain relative stable. These findings can be used for determination of abnormal growth of the fetuses in prenatal ultrasound scan. Graphic Abstract
    Type of Medium: Online Resource
    ISSN: 1476-7120
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2105610-9
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  • 7
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2023
    In:  Health Information Science and Systems Vol. 11, No. 1 ( 2023-01-28)
    In: Health Information Science and Systems, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2023-01-28)
    Type of Medium: Online Resource
    ISSN: 2047-2501
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2697647-X
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  • 8
    In: Journal of Plant Growth Regulation, Springer Science and Business Media LLC
    Type of Medium: Online Resource
    ISSN: 0721-7595 , 1435-8107
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 1462091-1
    detail.hit.zdb_id: 586787-3
    SSG: 12
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  • 9
    In: European Journal of Pharmacology, Elsevier BV, Vol. 884 ( 2020-10), p. 173444-
    Type of Medium: Online Resource
    ISSN: 0014-2999
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 80121-5
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    Informa UK Limited ; 2023
    In:  The Journal of Maternal-Fetal & Neonatal Medicine Vol. 36, No. 1 ( 2023-12-31)
    In: The Journal of Maternal-Fetal & Neonatal Medicine, Informa UK Limited, Vol. 36, No. 1 ( 2023-12-31)
    Type of Medium: Online Resource
    ISSN: 1476-7058 , 1476-4954
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2080626-7
    detail.hit.zdb_id: 2077261-0
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