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  • 1
    In: BMC Infectious Diseases, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-03-29)
    Abstract: To estimate crude mortality, excess mortality, and standardized mortality rates (SMR) among people living with HIV (PLHIV) initiating highly active antiretroviral therapy (HAART) in Luzhou, China 2006–2020, and assess associated factors. Methods PLHIV initiating HAART in the HIV/AIDS Comprehensive Response Information Management System (CRIMS) in Luzhou, China 2006–2020 were included in the retrospective cohort study. The crude mortality, excess mortality, and SMR were estimated. Multivariable Poisson regression model was used for analyzing risk factors associated with excess mortality rates. Results The median age among 11,468 PLHIV initiating HAART was 54.5 years (IQR:43.1–65.2). The excess mortality rate decreased from 1.8 deaths/100 person-years (95% confidence interval [CI]:1.4–2.4) in 2006–2011 to 0.8 deaths/100 person-years (95%CI:0.7–0.9) in 2016–2020. SMR decreased from 5.4 deaths/100 person-years (95%CI:4.3–6.8) to 1.7 deaths/100 person-years (95%CI:1.5–1.8). Males had greater excess mortality with the eHR of 1.6 (95%CI:1.2–2.1) than females. PLHIV with CD4 counts ≥ 500 cells/μL had the eHR of 0.3 (95%CI:0.2–0.5) in comparison to those with CD4 counts  〈  200 cells/μL. PLHIV with WHO clinical stages III/IV had greater excess mortality with the eHR of 1.4 (95%CI:1.1–1.8). PLHIV with time from diagnosis to HAART initiation ≤ 3 months had the eHR of 0.7 (95%CI:0.5–0.9) compared to those with time ≥ 12 months. PLHIV with initial HAART regimens unchanged and viral suppression had the eHR of 1.9 (95%CI:1.4–2.6) and 0.1 (95%CI:0.0–0.1), respectively. Conclusions The excess mortality and SMR among PLHIV initiating HAART in Luzhou, China decreased substantially from 2006 to 2020, but the mortality rate among PLHIV was still higher than general population. PLHIV who were male, with baseline CD4 counts less than 200 cells/μL, WHO clinical stages III/IV, time from diagnosis to HAART initiation ≥ 12 months, initial HAART regimens unchanged, and virological failure had a greater risk of excess deaths. Early and efficient HAART would be significant in reducing excess mortality among PLHIV.
    Type of Medium: Online Resource
    ISSN: 1471-2334
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2041550-3
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  • 2
    In: Journal of Affective Disorders, Elsevier BV, Vol. 183 ( 2015-09), p. 75-82
    Type of Medium: Online Resource
    ISSN: 0165-0327
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2015
    detail.hit.zdb_id: 1500487-9
    SSG: 12
    SSG: 5,2
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  • 3
    In: Applied Organometallic Chemistry, Wiley, Vol. 35, No. 11 ( 2021-11)
    Abstract: To mimic photosynthesis in green plants, it is a crucial challenge to drive water oxidation and CO 2 reduction in one single system. In this study, we present a bioinspired trinuclear pyridinedicarboxylate cobalt complex (Et 3 NH) 2 [Co III 2 Co II (OH 2 )(pda) 5 ]·H 2 O ( 1 ) that is capable of homogeneously electrocatalytic water oxidation and CO 2 reduction simultaneously. The designed mix‐valent cobalt complex is in a V‐configuration composed of two terminal Co III ions and one central Co II ion coordinated with one water ligand, which is resemble to aqua ligation of the natural catalytic complex in oxygen‐evolving complex (OEC). The electrochemical results show that this trinuclear cobalt complex could electrocatalyze water oxidation under neutral condition at the potentials of 1.15 V and 2.00 V versus NHE, with the Faraday efficiency as high as about 96% and 82%, and the TOF of 2.22 and 10.20 s −1 , respectively. Meanwhile, it also displays electrocatalytic activity for the reduction of CO 2 to CO with the TOF of 0.93 s −1 . The cobalt complex has good catalytic performance for the conversion of H 2 O and CO 2 into O 2 and CO, respectively, which may be mainly due to the key role of the flexible water ligand on the central Co II ion in the catalytic process. This work represents the first multinuclear cobalt complex for mimicking bio‐system to drive water oxidation coupled with carbon dioxide reduction simultaneously.
    Type of Medium: Online Resource
    ISSN: 0268-2605 , 1099-0739
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1480791-9
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  • 4
    Online Resource
    Online Resource
    Wiley ; 2019
    In:  Journal of Cellular Biochemistry Vol. 120, No. 4 ( 2019-04), p. 4851-4862
    In: Journal of Cellular Biochemistry, Wiley, Vol. 120, No. 4 ( 2019-04), p. 4851-4862
    Abstract: Mounting evidence has demonstrated that long noncoding RNAs (lncRNAs) are dysregulated and implicated in the occurrence and development of a wide range of human malignancies. LINC00461, a novel cancer‐related lncRNA, has been reported to be highly expressed and serve as oncogene in glioma; however, its biological role in breast cancer (BC) remains obscure. This study aimed to explore the role of LINC00461 in BC and elucidate the potential molecular mechanisms involved. In the current study, LINC00461 was found to be significantly upregulated in both BC tissues and cell lines. Besides, we found that high LINC00461 expression was associated with TNM stage and differentiation. Furthermore, functional studies demonstrated that LINC00461 expedited BC cell migration and invasion. Notably, LINC00461 was observed to enhance the expression of vimentin and zinc‐finger E‐box binding homeobox factor 1, suppress the expression of E‐cadherin, and promote the activation of extracellular signal‐regulated kinase and AKT signaling pathways. Mechanical investigations revealed that LINC00461 positively modulated integrin β3 (ITGB3) expression as miR‐30a‐5p sponge in BC cells. Taken together, LINC00461 exerts an oncogenic role in BC through miR‐30a‐5p/ITGB3 axis. Our data indicate that LINC00461 may be used to be a novel candidate therapeutic target and a valuable diagnostic biomarker for BC.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 5
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-12
    Abstract: Tao-Hong-Si-Wu decoction (TSD) as a traditional chinese medicine (TCM) has been developed to treat thrombotic diseases for hundreds of years, and vascular dementia (VD) is a cognitive dysfunction syndrome caused by cerebral embolism. In this study, the protective effect of TSD on memory impairment and brain damage in rat model of VD induced by middle cerebral artery occlusion (MCAO) was investigated. The study showed that rats in MCAO treatment with TSD for 14 days significantly improved behavioral function, increased densities of neuron, and induced angiogenesis in the brain compared with model rats. TSD also adjusted the neurotransmitter levels, reduced the content of endothelin-1 (ET-1), and induced the activities of vascular endothelial growth factor (VEGF) in hippocampus. Moreover, the immunohistochemical staining and western blotting results also revealed that TSD decreased apoptosis via upregulated B-cell lymphoma-2 (Bcl-2)/Bcl-2 associated X protein (Bax) ratio. These results demonstrated TSD possesses neuroprotective and antidementia properties by preventing the loss of neural cells, adjusting brain neurotransmitter, promoting cerebral blood circulation, and decreasing apoptosis. These results suggested that TSD might be developed as an effective drug for the prevention of VD.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2148302-4
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  • 6
    In: Advanced Functional Materials, Wiley
    Abstract: Sodium metal batteries (SMBs) using gel polymer electrolytes (GPEs) with high theoretical capacity and low production cost are regarded as a promising candidate for high energy‐density batteries. However, the inherent flammability of GPEs and uncontrolled Na dendrite caused by inferior mechanical properties and interfacial stability hinder their practical applications. Herein, an anion‐trapping fireproof composite gel electrolyte (AT‐FCGE) is designed through a chemical grafting–coupling strategy, where functionalized boron nitride nanosheets (M‐BNNs) used as both nanosized crosslinker and anion capturer are coupled with poly(ethylene glycol)diacrylate in poly(vinylidene fluoride‐co‐hexafluoropropylene) matrix, to expedite Na + transport and suppress dendrite growth. Experimental and calculation studies suggest that the anion‐trapping effect of M‐BNNs with abundant Lewis‐acid sites can promote the dissociation of salts, thus remarkably improving the ionic conductivity and Na + transference number. Meanwhile, the formation of highly crosslinked semi‐interpenetrating network can effectively in situ encapsulate non‐flammable phosphate without sacrificing the mechanical properties. Consequently, the resulting AT‐FCGE shows significantly enhanced Na + conductivity, mechanical properties, and excellent interfacial stability. The AT‐FCGE enables a long‐cycle stability dendrite‐free Na/Na symmetric cell, and prominent electrochemical performance is demonstrated in solid‐state SMBs. The approach provides a broader promise for the great potential of fire‐retardant gel electrolytes in high‐performance SMBs and the beyond.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 7
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 10 ( 2022-6-2)
    Abstract: This study aimed to evaluate HIV incidence, factors associated with HIV incidence and transmitted drug resistance (TDR) among newly infected men who have sex with men (MSM) in Harbin, P.R. China. Methods A cohort study was conducted among MSM in Harbin during 2013 and 2018, with a follow-up frequency of every 6 months. Blood samples from MSM were tested for HIV antibodies, RNA was extracted from plasma, and the pol gene was sequenced, and genotypic drug-resistance analyses were performed. Results From 2013 to 2018, the overall rate of HIV incidence was 3.55/100 PY. Syphilis infection, unprotected sex with men in the past 6 months, and unawareness of HIV/AIDS knowledge were risk factors for HIV seroconversion. The distribution of HIV genotypes was as follows: CRF01_AE, 57.1%; CRF07_BC, 28.5%; CRF55_01B, 2.0%; B, 8.2%. The prevalence of transmitted drug resistance was 4.08%. Conclusion HIV incidence in MSM in Harbin is moderately high, and transmitted drug resistance exists in the population.
    Type of Medium: Online Resource
    ISSN: 2296-2565
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2711781-9
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  • 8
    Online Resource
    Online Resource
    MDPI AG ; 2023
    In:  International Journal of Environmental Research and Public Health Vol. 20, No. 3 ( 2023-02-03), p. 2714-
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 20, No. 3 ( 2023-02-03), p. 2714-
    Abstract: Background: The proportion of elderly people living with HIV (PLHIV) is increasing in China. To advance targeted interventions and substantially improve their quality of life, we investigate indicators of loneliness and sexual behavior among elderly PLHIV in 10 districts/counties in China during the COVID-19 pandemic. Methods: The demographic information and laboratory test results of the potential respondents were initially collected from the China Information System for Disease Control and Prevention. A two-stage stratified cluster sampling was used. The questionnaire survey was individually provided to all PLHIV aged +60. Results: We recruited 1017 valid respondents with a median age of 66 years (interquartile range of 63–71), of which 776 (76.3%) were male. Overall, 341 respondents (33.5%) lived alone, and 304 (29.9%) felt lonely. A total of 726 respondents (71.4%) informed others of their HIV diagnosis. Among the 726 respondents, children were the most common group with whom the older people shared their HIV infection status, accounting for 82.9%. Approximately 20% of the older PLHIV engaged in sexual behavior in the last year, and 70% reported not using condoms. A significantly greater risk of loneliness was found among the females (AOR = 1.542, CI: 1.084, 2.193), those who suffered discrimination from informed people (AOR = 4.719, CI: 2.986, 7.459), were diagnosed 〈 1 year prior (AOR = 2.061, CI: 1.345, 3.156), those living alone (AOR = 2.314, CI: 1.632, 3.280), those having no friends (AOR = 1.779, CI: 1.327, 2.386), and those who had a divorced or widowed marital status (AOR = 1.686, CI: 1.174, 2.421). Conclusions: Compared with non-lonely participants, the lonely participants were more likely to have a rural registered residence, a lower education level, no friends, be divorced or widowed, live alone, and lack knowledge of smartphones and reproductive health. The influence of COVID-19 had caused social activities to be more confined to the community, which impacts elderly HIV patients suffering from severe discrimination within families and communities.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2175195-X
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  • 9
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Immunology Vol. 12 ( 2021-5-28)
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 12 ( 2021-5-28)
    Abstract: Since December 2019, the SARS-CoV-2 has erupted on a large scale worldwide and spread rapidly. Passive immunization of antibody-related molecules provides opportunities for prevention and treatment of high-risk patients and children. Nanobodies (Nbs) have many strong physical and chemical properties. They can be atomized, administered by inhalation, and can be directly applied to the infected site, with fast onset, high local drug concentration/high bioavailability, and high patient compliance (no needles). It has very attractive potential in the treatment of respiratory viruses. Rapid and low-cost development of Nbs targeting SARS-CoV-2 can quickly be achieved. Nbs against SARS-CoV-2 mutant strains also can be utilized quickly to prevent the virus from escaping. It provides important technical supports for the treatment of the SARS-CoV-2 and has the potential to become an essential medicine in the toolbox against the SARS-CoV-2.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606827-8
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  • 10
    Online Resource
    Online Resource
    SPIE-Intl Soc Optical Eng ; 2023
    In:  Journal of Electronic Imaging Vol. 32, No. 01 ( 2023-2-16)
    In: Journal of Electronic Imaging, SPIE-Intl Soc Optical Eng, Vol. 32, No. 01 ( 2023-2-16)
    Type of Medium: Online Resource
    ISSN: 1017-9909
    Language: Unknown
    Publisher: SPIE-Intl Soc Optical Eng
    Publication Date: 2023
    detail.hit.zdb_id: 2032860-6
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