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  • Chen, Dongju  (5)
  • 1
    In: Journal of Ovarian Research, Springer Science and Business Media LLC, Vol. 16, No. 1 ( 2023-03-15)
    Kurzfassung: Homologous Recombination Deficiency (HRD) is a predictive biomarker for ovarian cancer treated with PARP inhibitors or for breast cancer treated with first-line platinum-based chemotherapy. However, limited research is documented on platinum-based treatment prediction with HRD as a biomarker in ovarian cancer patients, especially in the Chinese population. Methods We investigated the association between HRD status and the response of platinum-based chemotherapy in 240 Chinese HGSOC patients. Results The Pt-sensitive patients showed higher HRD scores than Pt-resistant ones, but this was not significant(median: 42.6 vs. 31.6, p = 0.086). (Pt)-sensitive rate was higher in HRD +  BRCA m tumors and in HRD +  BRCA wt tumors (HRD +  BRCA m: 97%, p  = 0.004 and HRD +  BRCA wt: 90%, p  = 0.04) compared with 74% in the HRD- BRCA wt tumors. We also found Pt-sensitive patients tend to be enriched in patients with BRCA mutations or non- BRCA HRR pathway gene mutations ( BRCA : 93.6% vs 75.4%, p   〈  0.001; non- BRCA HRR: 88.6% vs 75.4%, p  = 0.062). Patients with HRD status positive had significantly improved PFS compared with those with HRD status negative (median PFS: 30.5 months vs. 16.8 months, Log-rank p  = 0.001). Even for BRCAwt patients, positive HRD was also associated with better PFS than the HRD-negative group (median: 27.5 months vs 16.8 months, Log-rank p  = 0.010). Further, we found patients with pathogenic mutations located in the DNA-binding domain (DBD) of BRCA1 had improved FPS, compared to those with mutations in other domains. ( p  = 0.03). Conclusions The HRD status can be identified as an independent significance in Chinese HGSOC patients treated with first-line platinum-based chemotherapy.
    Materialart: Online-Ressource
    ISSN: 1757-2215
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2023
    ZDB Id: 2455679-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 2018
    In:  Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Vol. 232, No. 2 ( 2018-02), p. 155-165
    In: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, SAGE Publications, Vol. 232, No. 2 ( 2018-02), p. 155-165
    Kurzfassung: In order to improve the machining precision of the aerostatic bearing, an eccentric rotor orbit model considering the microscale effects is established. A flow factor Q embodying the effects in the microscale is introduced into the fluid control equation, the dynamic stiffness, and damping coefficients of bearing are calculated considering the microscale effects. According to the actual working condition of the shaft, the modal analysis in both cases (with and without the microscale effects) is performed. And with the modal information, the dynamic orbit in both states (with and without the microscale effects) is described by the deduced orbit model of the shaft system. Finally, experiments of the frequency by LMS vibration test system and shaft orbit by displacement sensor are measured, and the results indicate that the simulated results considering the microscale effects are more similar with the actual experimental one, which provides a guideline and evaluation standard for further optimization design and precision control of the shaft system.
    Materialart: Online-Ressource
    ISSN: 1350-6501 , 2041-305X
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2018
    ZDB Id: 2032767-5
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 2018
    In:  Advances in Mechanical Engineering Vol. 10, No. 1 ( 2018-01), p. 168781401774714-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 10, No. 1 ( 2018-01), p. 168781401774714-
    Kurzfassung: In ultra-precision fly-cutting machining, the aerostatic spindle is the key component, which has significant influence on the machined surface quality. The unbalanced spindle directly affects the machining accuracy. In this article, a prediction model of machining surface topography is proposed which involves the effect of the gas film performance of spindle in microscale. With the Weierstrass function, unstable transient response of the aerostatic spindle system is derived by the motion model of the spindle, which response signal represents the surface profile in the ultra-precision machining. Meanwhile, the experiment is performed with different rotation speed of the spindle. And the effect of the unbalanced aerostatic spindle on the surface generation is discussed in time and frequency domain. The conclusion shows that the similar cyclical surface ripple of the workpiece is independent of the spindle speed, and the rotation speed of the spindle and unbalanced spindle directly affects the machining surface topography. This study is quite meaningful for deeply understanding the influence rule of spindle unbalanced error from the viewpoint of machined surface and vibration frequency.
    Materialart: Online-Ressource
    ISSN: 1687-8140 , 1687-8140
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2018
    ZDB Id: 2501620-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 2018
    In:  Proceedings of the Institution of Mechanical Engineers, Part K: Journal of Multi-body Dynamics Vol. 232, No. 4 ( 2018-12), p. 521-535
    In: Proceedings of the Institution of Mechanical Engineers, Part K: Journal of Multi-body Dynamics, SAGE Publications, Vol. 232, No. 4 ( 2018-12), p. 521-535
    Kurzfassung: Vibration is one of the key factors that influences the ultra-precision machining. Taking the air-bearing work-stage for an example, the vertical vibration of the slide plate will directly affect the surface accuracy of machined parts. There are many factors that affect the vibration of precision machine tools, for example, the fluctuation of gas source, noise, environment, and so on. It will affect the machining accuracy and machining efficiency and cannot work in severe cases. Where the lubrication of the gas film in the air-bearing work-stage is in the micro scale category, its flow characteristics are different from the macroscopic gas flow, and it will also affect the stability of the sliding plate. This paper analyzed the vertical vibration characteristics of the air-bearing work-stage by considering the characteristics of gas film in micro scale when the velocity of the slide plate is 0. Based on the Reynolds equation and the characteristics of gas flow, the stiffness ( K) and the damping ( C) of the gas film are obtained by considering different micro factors. The gas film is assumed as the spring system. Then the stiffness and damping of the gas film are taken into the vibration equation of the slide plate. Through solving the vibration equations, the influence of the micro factor of the fluid on the vibration of the slide plate is researched. The results show that when considering the micro factors of the lubrication gas film, the vibration amplitude of slide plate and the frequency at the maximum amplitude are different from the one in macroscopic without considering any micro factors. At the same thickness of the gas film, the influence of the micro factors on the amplitude of slide plate is largest when three micro scale factors (the first order velocity slip, the flow factor Q and the effective viscosity) are considered. With the increase of the film thickness, the micro scale factors have the little effect on the frequency at the maximum amplitude. By analyzing the dimensionless parameters of the experimental signals and the different simulation signals, we found that when the micro-scale factors are considered at the same time, the vibration amplitude of the slide plate and the frequency at the maximum amplitude are closest to the experimental result. It is proved that combined with the micro scale factor, the analysis of dynamic characteristics of air-bearing work-stage is more accurate.
    Materialart: Online-Ressource
    ISSN: 1464-4193 , 2041-3068
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2018
    ZDB Id: 2032771-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Elsevier BV ; 2018
    In:  Mechanical Systems and Signal Processing Vol. 105 ( 2018-05), p. 488-501
    In: Mechanical Systems and Signal Processing, Elsevier BV, Vol. 105 ( 2018-05), p. 488-501
    Materialart: Online-Ressource
    ISSN: 0888-3270
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2018
    ZDB Id: 1471003-1
    Standort Signatur Einschränkungen Verfügbarkeit
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