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  • 1
    Online-Ressource
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    The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing
    Oxford University Press (OUP) ; 2021
    In:  Burns & Trauma Vol. 9 ( 2021-01-01)
    Details
    In: Burns & Trauma, Oxford University Press (OUP), Vol. 9 ( 2021-01-01)
    Kurzfassung: The epidermis is the outermost layer of skin and the first barrier against invasion. Dendritic epidermal T cells (DETCs) are a subset of γδ T cells and an important component of the epidermal immune microenvironment. DETCs are involved in skin wound healing, malignancy and autoimmune diseases. DETCs secrete insulin-like growth factor-1 and keratinocyte growth factor for skin homeostasis and re-epithelization and release inflammatory factors to adjust the inflammatory microenvironment of wound healing. Therefore, an understanding of their development, activation and correlative signalling pathways is indispensable for the regulation of DETCs to accelerate wound healing. Our review focuses on the above-mentioned molecular mechanisms to provide a general research framework to regulate and control the function of DETCs.
    Materialart: Online-Ressource
    ISSN: 2321-3876
    URL: Article
    DOI: 10.1093/burnst/tkab009
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2021
    ZDB Id: 2775996-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
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    Environmental, Social, and Governance Incidents and Bank Loan Contracts
    MDPI AG ; 2021
    In:  Sustainability Vol. 13, No. 4 ( 2021-02-09), p. 1885-
    Details
    In: Sustainability, MDPI AG, Vol. 13, No. 4 ( 2021-02-09), p. 1885-
    Kurzfassung: We investigated how a borrower’s adverse environmental, social, and governance incidents affect bank loan contracts. Using a sample of 2001 publicly traded US firms during the period from 2007 to 2016, we found that loans initiated after the occurrence of a firm’s environmental, social, or governance-related incident have a significantly higher spread and a lower loan size. Our sample contained firms covered by RepRisk, as RepRisk began tracking firms’ environmental, social, and governance-related incidents in January 2007. Further analysis showed that the influence on loan contracts is more pronounced in younger firms, which verifies that environmental, social, and governance-related incidents have significant influence and higher information asymmetry. In addition, a test of the timing of the environmental, social, and governance-related incidents in a year further strengthened our conclusions. Moreover, the impact of environmental, social, and governance-related incidents on loan contracts was also reflected in other non-monetary items, such as the duration of a loan contract, requests for collateral, and the frequency of covenants, as well as the lender structure. This paper adds to the discussion on the economic effects of environmental, social, and governance-related incidents on bank contracts. More broadly, our results contribute to the public policy discussion on the role banks should play in the transition to a low-carbon and sustainable economy.
    Materialart: Online-Ressource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su13041885
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2021
    ZDB Id: 2518383-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
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    Dendritic epidermal T cells secreting exosomes promote the proliferation of epidermal stem cells to enhance wound re-epithelialization
    Springer Science and Business Media LLC ; 2022
    In:  Stem Cell Research & Therapy Vol. 13, No. 1 ( 2022-03-21)
    Details
    In: Stem Cell Research & Therapy, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2022-03-21)
    Kurzfassung: Efficient re-epithelialization is important for successful skin wound healing. The proportion of epidermal stem cells (EpSCs) and dendritic epidermal T cells (DETCs) determines the extent of wound re-epithelialization, especially in large areas of skin tissue loss. However, it remains unknown whether and how DETCs regulate the status of EpSCs to impact wound re-epithelialization. Methods To investigate how DETCs regulate EpSCs in skin re-epithelialization, we utilized normal or full-thickness skin deficient wide type (WT) mice and Tcrσ knockout (Tcrσ −/− ) mice with DETCs or DETCs-derived exosomes (Exos) treatment. Flow cytometry analysis (FCAS), BrdU labelled experiments, immunofluorescence and immunohistochemical assays were performed to detect the proportion of EpSCs in the epidermis. Wound closure rate and re-epithelialization were assayed by a macroscopical view and hematoxylin–eosin (H & E) staining. EpSCs in vitro were co-cultured with DETCs in a transwell-dependent or -independent manner, or supplement with GW4869 or Exos (5 µg/mL, 15 µg/mL and 45 µg/mL), and the proliferation of EpSCs was detected by means of FCAS and CFSE. Results Our data showed that the proportion of CD49f bri CD71 dim cells, K15 + cells and BrdU + cells in the normal epidermis of Tcrδ −/− mice had no significant difference compared to WT mice. For wounded Tcrδ −/− mice, DETCs treatment increase the proportion of CD49f bri CD71 dim cells, K15 + cells and BrdU + cells in the epidermis around the wound in comparison to PBS treatment. DETCs significantly increased the number of CD49f bri CD7 dim cells and K15 + cells through transwell-dependent or -independent manners relative to control group. Furthermore, Exos stimuli remarkedly promote the proliferation of EpSCs compared to control group, while the increasement was suppressed when DETCs were interfered with GW4869. Gross observation and H & E staining showed that Exos significantly accelerated wound closure and increased re-epithelialization length in Tcrδ −/− mice when compared to control mice. Additionally, we found in vivo that Exos observably facilitated the proliferation of CD49f bri CD7 dim cells and K15 + cells. Conclusions We revealed that DETCs enhanced the proliferation of EpSCs in the epidermis around the wounds to accelerate re-epithelialization in which Exos played important roles in the remote regulation of EpSCs proliferation. Together, these findings suggest a mechanistic link among DETC-derived exosomes, the proliferation of EpSCs, and wound re-epithelialization in the skin.
    Materialart: Online-Ressource
    ISSN: 1757-6512
    URL: Article
    DOI: 10.1186/s13287-022-02783-6
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2022
    ZDB Id: 2548671-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    Weakly coupled hybrid guided mode resonance optical transmission filter
    Optica Publishing Group ; 2022
    In:  Journal of the Optical Society of America B Vol. 39, No. 4 ( 2022-04-01), p. 925-
    Details
    In: Journal of the Optical Society of America B, Optica Publishing Group, Vol. 39, No. 4 ( 2022-04-01), p. 925-
    Kurzfassung: Hybrid metal-dielectric guided mode resonance devices have an advantage over the all-dielectric guided mode resonance device for having a thin metal grating conductive layer that can be used as an electrode for tunable applications. In this work, we investigate the coupling between the waveguide mode and surface plasmons of the gold nanoslits grating in the hybrid guided mode resonance filter. It is shown that the coupling between the waveguide mode and surface plasmons can be engineered by increasing either the thickness of the low index of the refraction spacing layer or the thickness of the high index of the refraction waveguide layer. Therefore, a narrow spectral linewidth and a high finesse of hybrid guided mode resonance filters can be obtained by increasing the thickness of the low index of the refraction spacing layer or the thickness of the high index of the refraction waveguide layer. A hybrid guided mode resonance transmission filter with a narrow spectral linewidth of 2.8 nm is designed at the 1660.2 nm center wavelength.
    Materialart: Online-Ressource
    ISSN: 0740-3224 , 1520-8540
    URL: Article
    DOI: 10.1364/JOSAB.447350
    Sprache: Englisch
    Verlag: Optica Publishing Group
    Publikationsdatum: 2022
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    P311 Promotes IL-4 Receptor‒Mediated M2 Polarization of Macrophages to Enhance Angiogenesis for Efficient Skin Wound Healing
    Elsevier BV ; 2023
    In:  Journal of Investigative Dermatology Vol. 143, No. 4 ( 2023-04), p. 648-660.e6
    Details
    In: Journal of Investigative Dermatology, Elsevier BV, Vol. 143, No. 4 ( 2023-04), p. 648-660.e6
    Materialart: Online-Ressource
    ISSN: 0022-202X
    URL: Article
    DOI: 10.1016/j.jid.2022.09.659
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2023
    ZDB Id: 2006902-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    Presentation_1.pptx
    Frontiers Media SA ; 2022
    In:  Frontiers in Immunology Vol. 13 ( 2022-1-28)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-1-28)
    Kurzfassung: As a potential clinical therapeutic cell for injured tissue repair, mesenchymal stem cells (MSCs) have attracted increasing attention. Enhancing the pro-healing function of MSCs has gradually become an essential topic in improving the clinical efficacy of MSCs. Recently, studies have shown that neuronal protein 3.1 (P311) plays a crucial role in promoting skin wound healing, suggesting P311 gene modification may improve the pro-healing function of MSCs. In this study, we demonstrated that increasing the in vivo expression of P311 could significantly enhance the ability of MSCs to lessen the number of inflammatory cells, increase the expression of IL10, reduce the levels of TNF-α and IFN-γ, increase collagen deposition, promote angiogenesis, and ultimately accelerate skin wound closure and improve the quality of wound healing. Importantly, we uncovered that P311 enhanced the pro-angiogenesis function of MSCs by increasing the production of vascular endothelial growth factor (VEGF) in vitro and in vivo . Mechanistically, we revealed that the mTOR signalling pathway was closely related to the regulation of P311 on VEGF production in MSCs. Together, our data displayed that P311 gene modification in MSCs augments their capabilities to promote skin wound closure, which might bring the dawn for its clinical application in the future.
    Materialart: Online-Ressource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2022.821932
    DOI: 10.3389/fimmu.2022.821932.s001
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2022
    ZDB Id: 2606827-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
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    Skin γδ T Cells and Their Function in Wound Healing
    Frontiers Media SA ; 2022
    In:  Frontiers in Immunology Vol. 13 ( 2022-4-11)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-4-11)
    Kurzfassung: For the skin immune system, γδ T cells are important components, which help in defensing against damage and infection of skin. Compared to the conventional αβ T cells, γδ T cells have their own differentiation, development and activation characteristics. In adult mice, dendritic epidermal T cells (DETCs), Vγ4 and Vγ6 γδ T cells are the main subsets of skin, the coordination and interaction among them play a crucial role in wound repair. To get a clear overview of γδ T cells, this review synopsizes their derivation, development, colonization and activation, and focuses their function in acute and chronic wound healing, as well as the underlining mechanism. The aim of this paper is to provide cues for the study of human epidermal γδ T cells and the potential treatment for skin rehabilitation.
    Materialart: Online-Ressource
    ISSN: 1664-3224
    URL: Article
    DOI: 10.3389/fimmu.2022.875076
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2022
    ZDB Id: 2606827-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    P311 promotes type II transforming growth factor-β receptor mediated fibroblast activation and granulation tissue formation in wound healing
    Oxford University Press (OUP) ; 2022
    In:  Burns & Trauma Vol. 10 ( 2022-01-01)
    Details
    In: Burns & Trauma, Oxford University Press (OUP), Vol. 10 ( 2022-01-01)
    Kurzfassung: P311, a highly conserved 8 kDa intracellular protein, has recently been reported to play an important role in aggravating hypertrophic scaring by promoting the differentiation and secretion of fibroblasts. Nevertheless, how P311 regulates the differentiation and function of fibroblasts to affect granulation tissue formation remains unclear. In this work, we studied the underlying mechanisms via which P311 affects fibroblasts and promotes acute skin wound repair. Methods To explore the role of P311, both in vitro and in vivo wound-healing models were used. Full-thickness skin excisional wounds were made in wild-type and P311−/− C57 adult mice. Wound healing rate, re-epithelialization, granulation tissue formation and collagen deposition were measured at days 3, 6 and 9 after skin injury. The biological phenotypes of fibroblasts, the expression of target proteins and relevant signaling pathways were examined both in vitro and in vivo. Results P311 could promote the proliferation and differentiation of fibroblasts, enhance the ability of myofibroblasts to secrete extracellular matrix and promote cell contraction, and then facilitate the formation of granulation tissue and eventually accelerate skin wound closure. Importantly, we discovered that P311 acts via up-regulating the expression of type II transforming growth factor-β receptor (TGF-βRII) in fibroblasts and promoting the activation of the TGF-βRII-Smad signaling pathway. Mechanistically, the mammalian target of rapamycin signaling pathway is closely implicated in the regulation of the TGF-βRII-Smad pathway in fibroblasts mediated by P311. Conclusions P311 plays a critical role in activation of the TGF-βRII-Smad pathway to promote fibroblast proliferation and differentiation as well as granulation tissue formation in the process of skin wound repair.
    Materialart: Online-Ressource
    ISSN: 2321-3876
    URL: Article
    DOI: 10.1093/burnst/tkac027
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2022
    ZDB Id: 2775996-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
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    Spatiotemporal orchestration of macrophage activation trajectories by Vγ4 T cells during skin wound healing
    Elsevier BV ; 2024
    In:  iScience Vol. 27, No. 4 ( 2024-04), p. 109545-
    Details
    In: iScience, Elsevier BV, Vol. 27, No. 4 ( 2024-04), p. 109545-
    Materialart: Online-Ressource
    ISSN: 2589-0042
    URL: Article
    DOI: 10.1016/j.isci.2024.109545
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2024
    ZDB Id: 2927064-9
    Standort Signatur Einschränkungen Verfügbarkeit
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