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  • Chaurasiya, Anand Kumar  (3)
  • 1
    Online Resource
    Online Resource
    Hematological Changes in Whole Blood Stored in Blood Bags Containing CPDA-1 Over a Period of 28 Days
    Nepal Journals Online (JOL) ; 2023
    In:  Med Phoenix Vol. 7, No. 2 ( 2023-01-06), p. 42-46
    Details
    In: Med Phoenix, Nepal Journals Online (JOL), Vol. 7, No. 2 ( 2023-01-06), p. 42-46
    Abstract: Introduction: Blood storage is needed to ensure a readily available and safe blood supply. During blood storage in blood bank, biochemical and physical properties of RBCs are altered because of storage conditions. In normal conditions in the body circulation, these do not occur as optimum pH, temperature, nutrient concentration and waste products removal are maintained. The aim of this study was to observe the changes in whole blood stored in blood bags containing CPDA-1 over a period of 28 days. Materials and Methods:  This was a hospital based observational study conducted in Blood Bank, National Medical College and Teaching Hospital (NMCTH), Birgunj. A total of 450 ml blood was drawn from 50 healthy volunteer donors into blood bags containing CPDA–1 anticoagulant and placed on the quarantine shelf of the blood bank refrigerator maintained at 2-8o centigrade. The blood bags were screened for HCV, HBsAg, syphillis and HIV. Ten milliliters blood was withdrawn from the blood bags on 1st, 7th, 14th, 21st, and 28th day and tested for hematological parameters using Yumizen H550 (HORIBA) fully automated hematology analyzer. Results: At the end of 28 days, whole blood storage in CPDA-1 revealed significant decrease in WBC (T = 4.79, p 〈 0.01) and platelets count (T=180.09, p 〈 0.01). Hematocrit increased significantly after 21 days of storage (T = 40.86, p 〈 0.01).  MCHC and MCH also demonstrated significant increase during the storage period (T = 37.32, p 〈 0.01) and (T = 29.38, p 〈 0.01), respectively. Conclusion:  WBC and platelets are significantly altered (decreased) when stored in blood bags containing CPDA- 1 after one week period. The study recommends   whole blood transfusion before seventh day of donation in order to avoid the adverse outcome of hematological changes in stored blood. In case it has to be used beyond one week, then it should be leukodepleted before storage.
    Type of Medium: Online Resource
    ISSN: 2631-1992 , 2392-425X
    URL: Article
    DOI: 10.3126/medphoenix.v7i2.50939
    Language: Unknown
    Publisher: Nepal Journals Online (JOL)
    Publication Date: 2023
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Iron Deficiency in Anemic Patients: Study in a Tertiary Care Centre
    Nepal Journals Online (JOL) ; 2022
    In:  Med Phoenix Vol. 6, No. 2 ( 2022-02-16), p. 21-24
    Details
    In: Med Phoenix, Nepal Journals Online (JOL), Vol. 6, No. 2 ( 2022-02-16), p. 21-24
    Abstract: Introduction Anemia is a clinical abnormality characterized by a reduction in hemoglobin concentration below the normal for age and sex. It can be of different types, the most common being iron deficiency anemia which affects mostly pregnant and lactating females and growing children in the developing world. Materials and Methods This was a hospital-based observational study conducted at National Medical College and Teaching Hospital, Pathology Department, Birgunj, Nepal. Patients above the age of 10 years of both sexes (male and females) having anemia ( males having hemoglobin level 〈 13 gm/dl and females having hemoglobin level 〈 12 gm/dl ) were included. After a detailed history, preliminary blood tests including complete blood counts, peripheral smear, and reticulocytes count were done. In patients suspected (microcytic hypochromic blood picture and normal reticulocytes count )  to have iron deficiency anemia, serum ferritin was done to confirm the diagnosis. Patients under the age of 10 years and those patients having blood malignancies (acute or chronic leukemia) were excluded from the study. Results Sixty anemic patients were found to have iron deficiency. Females were affected more (66%) with iron deficiency anemia than males (34%). There were two peaks (30% and 21%) in age groups 10 – 20 years and 61 – 70 years. Complete blood counts revealed a significant decrease in the value of red cell indices like mean corpuscular volume in 70% patients (Normal MCV 80 to 100 fl) and mean corpuscular hemoglobin in 72% patients (Normal MCH 27 to 33 pg ).  On peripheral smear, it was seen that most of the patients (72%) had microcytic hypochromic blood pictures. Iron deficiency anemia was more common in rural areas. Conclusion Iron deficiency anemia was the most common type of anemia. It is more common in females and the prevalence is more in rural areas.
    Type of Medium: Online Resource
    ISSN: 2631-1992 , 2392-425X
    URL: Article
    DOI: 10.3126/medphoenix.v6i2.37070
    Language: Unknown
    Publisher: Nepal Journals Online (JOL)
    Publication Date: 2022
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Study of Breast Lesions in a Tertiary Care Centre : A Retrospective Study
    Nepal Journals Online (JOL) ; 2017
    In:  Med Phoenix Vol. 2, No. 1 ( 2017-10-13), p. 48-51
    Details
    In: Med Phoenix, Nepal Journals Online (JOL), Vol. 2, No. 1 ( 2017-10-13), p. 48-51
    Abstract: Background: To study the prevalence of various type of breast lesions in a tertiary care centre.Methods : The period of study was one year , from 1st January 2015 to 31st December 2015. Patients with breast lesions who came to department of pathology for Fine needle aspiration cytology were included in the study. There were 55 patients who came to the department for Fine needle aspiration cytology during one year period. Information pertaining to patients were taken from the medical record section and department of pathology of National medical college.Results: Out of 55 cases 17 patients (9.35%) were diagnosed with fibroadenosis, which was the highest followed by fibroadenoma (12 cases- 6.6%). Ductal hyperplasia was the least diagnosed disorder which was seen in only one patient (0.5%). Carcinoma of breast was diagnosed in three patients (1.65%). There were three (1.65%) male patients with breast lesions who were diagnosed with gynaecomastia.Conclusion: This study revealed that fibroadenosis was the most common disorder among the patients who came for fine needle aspiration cytology of the breast.Med Phoenix Vol.2(1) July 2017, 48-51
    Type of Medium: Online Resource
    ISSN: 2631-1992 , 2392-425X
    URL: Article
    DOI: 10.3126/medphoenix.v2i1.18387
    Language: Unknown
    Publisher: Nepal Journals Online (JOL)
    Publication Date: 2017
    Location Call Number Limitation Availability
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    Online Resource
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