In:
International Journal of Cancer, Wiley, Vol. 144, No. 4 ( 2019-02-15), p. 718-729
Abstract:
What's new? While diabetes mellitus (DM) is associated with an increased cancer risk, carcinogenesis may not be explained by the influence of higher blood glucose levels only. This prospective case‐cohort study shows that higher levels of surrogate insulin marker C‐peptide are significantly associated with an increased risk of all‐site, colon, liver, kidney, renal pelvis, and ureter cancers after adjustment for blood glucose levels. (Colon and liver cancers also showed an increased risk associated with elevated blood glucose levels independently of C‐peptide levels.) Higher insulin levels, independently of higher blood glucose levels, may thus be relevant to DM‐related carcinogenesis for several cancer sites.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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