In:
Journal of Neuroimaging, Wiley, Vol. 24, No. 1 ( 2014-01), p. 11-17
Abstract:
There are limited data available regarding symptomatic intracranial atherosclerosis (SIA) prevalence in Caucasians. We sought to investigate SIA prevalence among Caucasian patients hospitalized with acute cerebral ischemia (ACI) in a prospective, multicenter Transcranial Doppler sonography (TCD) study. METHODS Consecutive patients with ACI were prospectively evaluated with TCD over a 24‐month‐period. The previously validated criteria of SONIA trial were used for detection of 〉 50% intracranial stenosis with TCD. Brain angiography was performed to confirm the diagnosis in cases with abnormal TCD findings. SIA was diagnosed when there was evidence of a cerebral infarction in the territory of the stenotic artery (identified by TCD and confirmed by Magnetic resonance angiography [MRA]/Computed tomography angiography [CTA] ). RESULTS A total of 467 consecutive patients with ACI (60.4% men, mean age 58 ± 14 years) were evaluated. SIA was documented in 43 patients (9.2%; 95%CI: 6.9%‐12.2%). The most common SIA location was M1MCA (34.9%) followed by TICA (18.8%). Diabetes mellitus (OR: 4.25, 95%CI: 2.18‐8.26; P 〈 .001) and hypertension (OR: 2.41, 95%CI: 1.02‐5.67; P = .045) were independently associated with SIA on multivariate models adjusting for potential confounders. CONCLUSIONS SIA was identified in almost 10% of patients admitted with symptoms of ACI. These preliminary findings support further collaborative initiatives among stroke physicians to increase the yield of SIA detection in Caucasian patients with ACI.
Type of Medium:
Online Resource
ISSN:
1051-2284
,
1552-6569
DOI:
10.1111/jon.2014.24.issue-1
DOI:
10.1111/j.1552-6569.2012.00707.x
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2035400-9
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