In:
International Journal of Cancer, Wiley, Vol. 146, No. 2 ( 2020-01-15), p. 542-552
Abstract:
What's new? IL22 was reported to promote tumor cell growth, angiogenesis, and chemotherapeutic resistance. However, few studies have investigated the role of this cytokine in the development of immunosuppressive microenvironment. Our study found that IL22 + cells infiltration was an independent indicator of overall survival, recurrence‐free survival, and adjuvant chemotherapy benefit in muscle‐invasive bladder cancer (MIBC). The results also revealed the immunoregulatory role of IL22 + cells in the immunoevasive subtype of MIBC with CD8 + T cells exhaustion. The results supported IL22 + cells infiltration as a potential predictor for responsiveness to PD‐1 blockade and identified IL22 blockade as a novel immunotherapeutic strategy in MIBC.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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