In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-08-08)
Abstract:
We retrospectively reviewed the records of 142 patients with stage IB–IIIB cervical cancer who underwent 18 F-FDG-PET/CT before external beam radiotherapy plus intracavitary brachytherapy and concurrent chemotherapy. The patients were divided into training and validation cohorts to confirm the reliability of predictors for recurrence. Kaplan–Meier analysis was performed and a Cox regression model was used to examine the effects of variables on overall survival (OS), progression-free survival (PFS), distant metastasis-free survival (DMFS), and pelvic relapse-free survival (PRFS). High gray-level run emphasis (HGRE) derived from gray-level run-length matrix most accurately and consistently predicted the presence of pelvic residual or recurrent tumors for both cohorts. In multivariate analysis, stages IIIA–IIIB ( P = 0.001, hazard ratio [HR] = 4.07) and a low HGRE ( P 〈 0.0001, HR = 4.34) were prognostic factors for low OS, whereas a low HGRE ( P = 0.001, HR = 2.86) and nonsquamous cell histology ( P = 0.003, HR = 2.76) were prognostic factors for inferior PFS. The nonsquamous cell histology ( P 〈 0.0001, HR = 9.19) and a low HGRE ( P = 0.001, HR = 4.69) were predictors for low PRFS. In cervical cancer patients receiving definitive chemoradiotherapy, pretreatment textural features on 18 F-FDG-PET/CT can supplement the prognostic information.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-018-30336-6
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2018
detail.hit.zdb_id:
2615211-3
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