In:
International Journal of Cancer, Wiley, Vol. 138, No. 5 ( 2016-03), p. 1232-1245
Kurzfassung:
What's new? We identified a lipid raft protein flotillin‐1 as an important regulator of H‐Ras activation and breast cancer aggressiveness. Flotillin‐1 was required for epidermal growth factor‐induced activation of H‐Ras, but not that of N‐Ras, in triple‐negative breast cancer (TNBC) cells. Flotillin‐1 knockdown inhibited the invasiveness and tumorigenicity of TNBC cells in vivo . Using human breast cancer samples, we provide clinical evidence for the tumorigenic and metastatic potential of flotillin‐1 and its association with H‐Ras. Oncogenic activation of H‐Ras is a common feature of breast cancer, with the mutant protein serving a leading role in tumorigenesis and also likely contributing to the induction of tumor invasion and metastasis. In this study, the lipid raft protein flotillin‐1 was found to be a key regulator of H‐Ras activation and tumor aggressiveness in breast cancer. In triple‐negative breast cancer (TNBC) cells, flotillin‐1 was required for epidermal growth factor‐induced H‐Ras activation, and in vivo , flotillin‐1 knockdown inhibited TNBC invasiveness and tumorigenicity. In patient samples, flotillin‐1 membrane staining correlated positively with metastasized disease.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2016
ZDB Id:
218257-9
ZDB Id:
1474822-8
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