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  • 1
    Online Resource
    Online Resource
    A Retrospective Cohort Study on Patients with Lentigo Maligna Melanoma
    S. Karger AG ; 2019
    In:  Dermatology Vol. 235, No. 4 ( 2019), p. 340-345
    Details
    In: Dermatology, S. Karger AG, Vol. 235, No. 4 ( 2019), p. 340-345
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 More epidemiological data about lentigo maligna melanoma (LMM) are required to define follow-up guidelines. The study focused on recurrence, progression, and overall survival of LMM managed with primary wide local excision. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In a 23-year retrospective study (1994 to 2016), a cohort of patients with LMM was evaluated by collecting data about the tumor location, the Breslow depth, the presence of ulceration, and patients’ age and sex. Local recurrences, locoregional and distant metastases, and disease-free and overall survival were additionally assessed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Overall, 150 cases (84 male, 66 female, mean age 71.3 ± 11.3 years) of single, localized, primary LMM with a mean follow-up of 6.6 ± 4.4 years were included. A total of 33 (22.2%) patients underwent sentinel lymph node biopsy (SLNB) during surgical excision. However, positive SLNB was detected in none of them. The multivariable Cox analysis indicated that age of diagnosis and male gender significantly influenced the overall survival, while a shorter disease-free survival could be correlated with a greater Breslow thickness. The metastatic potential turned out to be low, entailing 7 deaths in the context of the LMM. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Male gender, age over 70 at diagnosis, and a Breslow thickness greater than 0.75 mm were associated with a statistically significant decrease in overall disease-free survival in the current study. The results of the study confirm the favorable outcome of LMM. However, diagnosed patients should undertake regular follow-ups. The intensity of follow-up in these patients can be individualized based on the probability of recurrence/metastasis and overall survival. Furthermore, the study showed that SLNB might not be a necessary staging procedure in patients with LMM.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000499689
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1482189-8
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  • 2
    Online Resource
    Online Resource
    Photodynamic therapy as an alternative treatment for mycosis fungoides: a systemic review and meta-analysis
    Edizioni Minerva Medica ; 2018
    In:  Giornale Italiano di Dermatologia e Venereologia Vol. 153, No. 6 ( 2018-12)
    Details
    In: Giornale Italiano di Dermatologia e Venereologia, Edizioni Minerva Medica, Vol. 153, No. 6 ( 2018-12)
    Type of Medium: Online Resource
    ISSN: 0392-0488 , 1827-1820
    URL: Article
    DOI: 10.23736/S0392-0488.18.05977-1
    Language: English
    Publisher: Edizioni Minerva Medica
    Publication Date: 2018
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  • 3
    Online Resource
    Online Resource
    Melanoma of the Nail Apparatus: An Analysis of Patients’ Survival and Associated Factors
    S. Karger AG ; 2022
    In:  Dermatology Vol. 238, No. 1 ( 2022), p. 156-160
    Details
    In: Dermatology, S. Karger AG, Vol. 238, No. 1 ( 2022), p. 156-160
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 There are no proper management guidelines for nail apparatus melanoma (NAM). 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 This study aimed to describe the clinical features, the presence of locoregional and distant metastases and disease-free and overall survival of NAM treated at our institution. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A retrospective cohort review of patients with single, primary localized histopathologically confirmed NAM was performed. Collected data consisted of patients’ characteristics and tumor features. In addition, local recurrence, locoregional metastases, distant metastases, disease-free survival (DFS) and overall survival (OS) were used as the main outcomes in our analysis. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Thirty patients with NAM were included. The overall survival (OS) in our patients at 5 and 10 years was 85.6 and 73.4%, respectively. DFS was significantly higher in patients with primary tumor location in the hand and without tumor-infiltrating lymphocytes ( 〈 i 〉 p 〈 /i 〉 value = 0.01 and 0.04, respectively). The patients with in situ melanoma or Breslow thickness & #x3c;1 mm had a significantly higher chance of DFS and OS (90.0 and 94.1% at 5 years, respectively) than those with thicker NAM (58.3 and 55.6% at 5 years, respectively). A total of 53.3% of 30 patients underwent primary excision and covering with a full-thickness skin graft, while 13.3% of our 30 patients underwent digit amputation. The patients who underwent excision and covering with a full-thickness skin graft showed a complete overall survival (100% at 5 years). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Primary tumor location in the hand and lower tumor thickness might be correlated with better patients’ survival. The study results suggest that total amputation might not be necessary in all NAM cases.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000514493
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    Efficacy Assessment of the High-Frequency High-Intensity Focused Ultrasound as a New Treatment for Actinic Keratosis
    S. Karger AG ; 2022
    In:  Dermatology Vol. 238, No. 4 ( 2022), p. 662-667
    Details
    In: Dermatology, S. Karger AG, Vol. 238, No. 4 ( 2022), p. 662-667
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Actinic keratosis (AK) is the most common precancerous cutaneous lesion, with risk of progression to cutaneous squamous cell carcinoma. In the current study, we evaluated the efficacy of 20-MHz high-intensity focused ultrasound (HIFU), as a new treatment modality for AK. 〈 b 〉 〈 i 〉 Materials and Methods: 〈 /i 〉 〈 /b 〉 Patients with AK lesions (grades I–III) treated with HIFU were included in the study. The clinical assessment was performed 3 months after therapy. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Twenty-one patients (14 men, 7 women) with 108 AK lesions (grades I–III) were included in the current study. Ages ranged from 62 to 85 years (mean 72.6 years). Clinically complete resolution of the actinic damage in the treated area was detected in 72.2% of lesions. Furthermore, 28 lesions (26%) showed a reduction of the AK grade, or partial response, after the therapy. Most of the patients experienced annoying but short pain during the procedure. However, late adverse effects of the therapy, such as hypopigmentation, hyperpigmentation and erythema were reported only in a small portion of the lesions. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 20-MHz HIFU could be an effective and safe alternative treatment for AK.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000520536
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 1482189-8
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  • 5
    Online Resource
    Online Resource
    Skin Hyperpigmentation Index Facilitating Quantification of Hyperpigmentation in Clinical Practice
    S. Karger AG ; 2021
    In:  Dermatology Vol. 237, No. 3 ( 2021), p. 486-488
    Details
    In: Dermatology, S. Karger AG, Vol. 237, No. 3 ( 2021), p. 486-488
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000509160
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    Long-Term Effectiveness and Drug Survival of Apremilast in Treating Psoriasis: A Real-World Experience
    S. Karger AG ; 2022
    In:  Dermatology Vol. 238, No. 2 ( 2022), p. 267-275
    Details
    In: Dermatology, S. Karger AG, Vol. 238, No. 2 ( 2022), p. 267-275
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Apremilast is an oral phosphodiesterase 4 (PDE4) inhibitor used for the treatment of moderate to severe psoriasis. Long-term data on the effectiveness and drug survival of patients treated with apremilast are limited. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 The aim of this study was to analyze the characteristics, effectiveness, and drug survival of patients treated with apremilast in a real-world setting. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We conducted a retrospective cohort study of patients with psoriasis who received at least 1 dose of apremilast between 2015 and 2018. We documented sex; age; type, duration, and severity (using Psoriasis Area Severity Index [PASI] and Dermatology Life Quality Index [DLQI] ) of psoriasis; comorbidities; previous treatment modalities; adverse events; and reasons for therapy discontinuation. For drug survival, estimates and efficacy analysis with Kaplan-Meier statistics were used. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The drug survival rate of the 93 reviewed patients was 69.5% at 6 months, 34.7% at 12 months, and 25.8% at 24 months after initiating therapy. The median survival duration was 8.0 months. Therapy was discontinued in 66.6 and 27.8% due to loss of efficacy and adverse events, respectively. At 24 months, 35.9% had achieved PASI75 response and 23.7% had achieved PASI90 response. Most observed adverse events were gastrointestinal issues, weight loss, and headache. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Apremilast is an effective and well-tolerated therapy for patients with moderate to severe psoriasis, especially for patients with difficult-to-treat locations and/or contraindications to other biologics. Furthermore, apremilast was used for patients with a history of nonresponse to biologics and was favored for patients with relatively low PASI ( & #x3c;10) and a high DLQI.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000515763
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
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  • 7
    Online Resource
    Online Resource
    The skin hyperpigmentation index: An objective method of measuring the intensity of hyperpigmentation after sclerotherapy
    SAGE Publications ; 2020
    In:  Phlebology: The Journal of Venous Disease Vol. 35, No. 10 ( 2020-12), p. 833-835
    Details
    In: Phlebology: The Journal of Venous Disease, SAGE Publications, Vol. 35, No. 10 ( 2020-12), p. 833-835
    Abstract: Skin hyperpigmentation in chronic venous insufficiency and as a side effect in vein treatments are of great importance for the affected individuals. There are only a few qualitatively limited methods that allow its quantification. Previous techniques to develop a reliable scientific approach to quantification have failed due to the lack of standardized conditions including differences in lighting, distances and equipment. A newly developed measuring method, the “skin hyperpigmentation index”, enables a fully automated and standardized quantification of skin hyperpigmentation with dermatoscopic images. The skin hyperpigmentation index defines the ratio of two scores, namely hyperpigmented skin of the affected area and normal sun protected skin from the same patient. This results in a range from 1 (no pigmentation) to 4 (maximum pigmentation). For a practical evaluation of the score, a free skin hyperpigmentation index calculator can be used online, which is accessible to all practitioners ( https://shi.skinimageanalysis.com/ ). The skin hyperpigmentation index is a fully automated method for the quantitative assessment of skin pigmentation which can easily be applied to any skin type with any type of hyperpigmentation. This allows a simple, fast, and standardized quantification of skin hyperpigmentation and is useful for monitoring the progress and planning of whitening therapy.
    Type of Medium: Online Resource
    ISSN: 0268-3555 , 1758-1125
    URL: Article
    DOI: 10.1177/0268355520941359
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 1463018-7
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  • 8
    Online Resource
    Online Resource
    Association of Hidradenitis Suppurativa With T Helper 1/T Helper 17 Phenotypes : A Semantic Map Analysis
    American Medical Association (AMA) ; 2018
    In:  JAMA Dermatology Vol. 154, No. 5 ( 2018-05-01), p. 592-
    Details
    In: JAMA Dermatology, American Medical Association (AMA), Vol. 154, No. 5 ( 2018-05-01), p. 592-
    Type of Medium: Online Resource
    ISSN: 2168-6068
    URL: Article
    DOI: 10.1001/jamadermatol.2018.0141
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2018
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  • 9
    Online Resource
    Online Resource
    Long-Term Follow-Up of Lentigo Maligna Patients Treated with Imiquimod 5% Cream
    MDPI AG ; 2023
    In:  Cancers Vol. 15, No. 5 ( 2023-02-28), p. 1546-
    Details
    In: Cancers, MDPI AG, Vol. 15, No. 5 ( 2023-02-28), p. 1546-
    Abstract: Background: The study investigated the long-term efficacy of imiquimod 5% cream for LM, with a focus on disease recurrence and the possible prognostic factors of disease-free survival (DFS) in a cohort, with long-term follow-up. Methods: Consecutive patients with histologically confirmed LM were included. Imiquimod 5% cream was applied until weeping erosion appeared on the LM-affected skin. The evaluation was performed through clinical examination and dermoscopy. Results: We analyzed 111 patients with LM (median age: 72 years, 61.3% women) with tumor clearance after imiquimod therapy, with a median follow-up of 8 years. The overall patient survival rates were 85.5% (95% confidence interval (CI): 78.5–92.6) and 70.4% (95% CI: 60.3–80.5) at 5 and 10 years, respectively. Among the 23 patients (20.1%) with relapse at follow-up, 17 (73.9%) were treated with surgery, five (21.7%) continued imiquimod therapy, and one (4.3%) underwent both surgery and radiotherapy. After adjustment for age and LM area in multivariable models, localization of LM in the nasal region was identified as a prognostic factor for DFS (HR = 2.66; 95% CI: 1.06–6.64). Conclusion: If surgical excision is not possible due to the patients’ age/comorbidities or critical cosmetic localization, imiquimod could provide optimal outcomes with an optimal risk of relapse for the management of LM.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    URL: Article
    DOI: 10.3390/cancers15051546
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2527080-1
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  • 10
    Online Resource
    Online Resource
    A Retrospective Cohort Study on Patients with Hidradenitis Suppurativa
    S. Karger AG ; 2018
    In:  Dermatology Vol. 234, No. 1-2 ( 2018), p. 71-78
    Details
    In: Dermatology, S. Karger AG, Vol. 234, No. 1-2 ( 2018), p. 71-78
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Hidradenitis suppurativa (HS) is one of the most distressing conditions observed in dermatology and has a substantial negative effect on the quality of life of affected persons. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 The aim of this study was to evaluate different treatment strategies in patients with HS. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In a retrospective cohort, all patients with HS (July 2015 to March 2017) were reviewed. Collected data consisted of patients’ demographics, clinical characteristics, psychosocial situation, and previous and current treatments. In addition, therapy response to the most recent prescribed treatments was assessed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 102 patients (38 females, 64 males; median age 37.5 years) were included in this study. 68.4% of patients had BMI ≥25, and 76.5% of patients were current smokers. Hurley stages I, II, and III were detected in 13.5, 53.1, and 33.3% of patients, respectively. The most commonly administered treatments were surgery (67.6%), nonantibiotic topical therapies (72.5%), antibiotic topical therapies (55.9%), systemic antibiotics (88.2%), and biologics in 11.8% of the patients. 84.6% of the patients showed a response (27.5 and 47.1% partial and complete response, respectively) to the treatments. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 HS as a chronic, recurrent inflammatory skin disease is associated with smoking and obesity. Application of systemic antibiotics is the most frequent treatment strategy for this disease. However, surgical intervention seems to be the most effective treatment strategy.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000488344
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
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