In:
Liver International, Wiley, Vol. 42, No. 6 ( 2022-06), p. 1386-1400
Abstract:
Non‐O blood group promotes deep vein thrombosis and liver fibrosis in both general population and hepatitis C. We aimed to evaluate the influence of Non‐O group on the outcome of Child‐Pugh A cirrhotic patients. Methods We used two prospective cohorts of Child‐Pugh A cirrhosis due to either alcohol or viral hepatitis. Primary end point was the cumulated incidence of ‘Decompensation’ at 3 years, defined as the occurrence of ascites , hydrothorax, encephalopathy, gastrointestinal bleeding related to portal hypertension, or bilirubin 〉 45 μmol/L. Secondary end points were the cumulated incidences of (1) ‘Disease Progression’ including a « decompensation» or « the occurrence of one or more parameters » among: prothrombin time (PT) 〈 45%, albumin 〈 28 g/L, Child‐Pugh worsening (B or C vs A or B, C vs B), hepatorenal syndrome, and hepato‐pulmonary syndrome, (2) other events such as non‐malignant portal vein thrombosis (nmPVT), and (3) overall survival. Results Patients (n = 1789; 59.9% Non‐O group; 40.1% group O) were followed during a median of 65.4 months. At 3 years cumulated incidence of Decompensation was 8.3% in Non‐O group and 7.2% in group O ( P = .27). Cumulated incidence of Disease Progression was 20.7% in Non‐O group and 18.9% in group O ( P = .26). Cumulated incidence of nmPVT was 2.7% in Non‐O group and 2.8% in group O ( P = .05). At 3 years overall survival was 92.4% in Non‐O group and 93.4% in group O ( P = 1). Conclusion Non‐O group does not influence disease outcome in Child‐Pugh A cirrhotic patients. Clinicals trial number NCT03342170.
Type of Medium:
Online Resource
ISSN:
1478-3223
,
1478-3231
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2124684-1
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