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  • Wiley  (7)
  • Cao, Jun  (7)
  • 1
    Online Resource
    Online Resource
    Impaired robust interhemispheric function integration of depressive brain from REST‐meta‐MDD database in China
    Wiley ; 2022
    In:  Bipolar Disorders Vol. 24, No. 4 ( 2022-06), p. 400-411
    Details
    In: Bipolar Disorders, Wiley, Vol. 24, No. 4 ( 2022-06), p. 400-411
    Abstract: Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. Methods In this study, we obtained resting‐state functional magnetic resonance imaging (R‐fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18–60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel‐mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. Results As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q  〈  0.002, z = −7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age‐related change in males instead of females. Besides, the reduction in MTG was found to be a male‐special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First‐episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. Conclusions We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres.
    Type of Medium: Online Resource
    ISSN: 1398-5647 , 1399-5618
    URL: Issue
    URL: Article
    DOI: 10.1111/bdi.v24.4
    DOI: 10.1111/bdi.13139
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001157-X
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  • 2
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    Online Resource
    Ion pair assisted micro matrix solid phase dispersion extraction of alkaloids from medical plant
    Wiley ; 2020
    In:  ELECTROPHORESIS Vol. 41, No. 1-2 ( 2020-01), p. 123-130
    Details
    In: ELECTROPHORESIS, Wiley, Vol. 41, No. 1-2 ( 2020-01), p. 123-130
    Abstract: A novel micro matrix solid phase dispersion method was successfully used for the extraction of quaternary alkaloids in Phellodendri chinensis cortex . The elution of target compounds was accomplished with sodium hexanesulfonate as the eluent solvent. A neutral ion pair was formed between ion‐pairing reagent and positively charged alkaloids in this process, which was beneficial for selectively extraction of polar alkaloids. Several parameters were optimized and the optimal conditions were listed as follows: silica gel as the sorbent, silica to sample mass ratio of 1:1, the grinding time of 1 min. The exhaustive elution of targets was achieved by 200 µL methanol/water (9:1) containing 150 mM sodium hexane sulfonate at pH 4.5. The method validation covered linearity, recovery, precision of intraday and interday, limits of detection, limits of quantitation, and repeatability. This established method was rapid, simple, environmentally friendly, and highly sensitive.
    Type of Medium: Online Resource
    ISSN: 0173-0835 , 1522-2683
    URL: Issue
    URL: Article
    DOI: 10.1002/elps.v41.1-2
    DOI: 10.1002/elps.201900244
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1475486-1
    SSG: 12
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  • 3
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    Online Resource
    Solid acids assisted matrix solid‐phase dispersion microextraction of alkaloids by capillary electrophoresis coupled with quadrupole time‐of‐flight mass spectrometry
    Wiley ; 2019
    In:  Journal of Separation Science Vol. 42, No. 23 ( 2019-12), p. 3579-3588
    Details
    In: Journal of Separation Science, Wiley, Vol. 42, No. 23 ( 2019-12), p. 3579-3588
    Abstract: The quantification of three alkaloids is important because quantitative study is a means of assessing the reliability of the experimental method, and three alkaloids of peimine, peiminine, and peimisine are main active ingredients in Chinese Pharmacopoeia 2015. An effective method based on the matrix solid‐phase dispersion microextraction was developed for the extraction of alkaloid compounds in Fritillariae Thunbergii Bulbus. Target analytes were analyzed by capillary electrophoresis coupled with quadrupole time‐of‐flight mass spectrometry. The optimized experimental condition was that 50 mg Fritillariae Thunbergii Bulbus was blended homogeneously with 10 mg citric acid for 5 min. Two hundred microliters of water acidized by 1 mol/L hydrochloric acid (pH = 4.5) was selected to elute tested alkaloids. The results demonstrated that the investigated method had low limits of detection (1.32–1.59 ng/mL), good recoveries (86.63–98.12%), and reproducibility (relative standard deviations of peak areas  〈  0.87%). The proposed matrix solid‐phase dispersion microextraction coupled with capillary electrophoresis combined with quadrupole time‐of‐flight mass spectrometry was successfully applied for the extraction of alkaloids in plants.
    Type of Medium: Online Resource
    ISSN: 1615-9306 , 1615-9314
    URL: Issue
    URL: Article
    DOI: 10.1002/jssc.v42.23
    DOI: 10.1002/jssc.201900647
    RVK:
    VA 5450
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2047990-6
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  • 4
    Online Resource
    Online Resource
    Analysis of isoquinoline alkaloids using chitosan‐assisted liquid–solid extraction followed by microemulsion liquid chromatography employing a sub‐2‐micron particle stationary phase
    Wiley ; 2016
    In:  ELECTROPHORESIS Vol. 37, No. 23-24 ( 2016-12), p. 3118-3125
    Details
    In: ELECTROPHORESIS, Wiley, Vol. 37, No. 23-24 ( 2016-12), p. 3118-3125
    Abstract: A simple, efficient, and green chitosan‐assisted liquid–solid extraction method was developed for the sample preparation of isoquinoline derivative alkaloids followed by microemulsion LC. The optimized mobile phase consisted of 0.8% w/v of ethyl acetate, 1.0% w/v of SDS, 8.0% w/v of n ‐butanol, 0.1% v/v acetic acid, and 10% v/v ACN. Compared to pharmacopoeia method and organic solvent extraction, this new approach avoided the use of volatile organic solvents, replacing them with relatively small amounts of chitosan. Under the optimum conditions, good linearity ( r 2 〉 0.9980) for all calibration curves and low detection limits between 0.05 and 0.10 μg/mL were achieved. The presented procedure was successfully applied to determine alkaloids in Rhizoma coptidis with satisfactory recoveries (81.3–106.4%).
    Type of Medium: Online Resource
    ISSN: 0173-0835 , 1522-2683
    URL: Issue
    URL: Article
    DOI: 10.1002/elps.v37.23-24
    DOI: 10.1002/elps.201600114
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1475486-1
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Cucurbituril and zwitterionic surfactant‐based matrix solid‐phase dispersion microextraction to simultaneously determine terpenoids from Radix Curcumae
    Wiley ; 2021
    In:  Journal of Separation Science Vol. 44, No. 7 ( 2021-04), p. 1361-1370
    Details
    In: Journal of Separation Science, Wiley, Vol. 44, No. 7 ( 2021-04), p. 1361-1370
    Abstract: A rapid, efficient, and environmentally friendly matrix solid‐phase dispersion microextraction was established to determine and quantify terpenoids in Radix Curcumae using ultra‐high‐performance liquid chromatography with a diode array detector. Various parameters affecting the extraction were investigated in detail, such as the grinding time, amount of adsorbent, type and concentration of elution solvent, and pH. The optimization of single‐factor and response surface methodology was performed to confirm the best conditions in this procedure. The final optimized conditions were obtained by applying 70 mg of cucurbituril as adsorbent, 149 s as the optimum grinding time, and 228 mM of 3‐(N,N‐dimethylpalmitylammonio)propanesulfonate aqueous solution (pH 6.5) as the optimal elution solvent. The validated method showed a satisfactory linear range of 0.10–10 µg/mL for curdione and furanodiene, 0.01–10 µg/mL for isocurcumenol and germacrone, and 0.05–10 µg/mL for furanodienone, while the correlation coefficients ranged from 0.9945 to 0.9970. The recoveries of the investigated analytes at two spiked concentration levels (0.1 and 1.0 µg/mL) ranged from 96.53 to 104.60%. In addition, this method displayed acceptable reproducibility (relative standard deviation ≤ 3.66%). The results showed that the newly proposed matrix solid‐phase dispersion microextraction method was successfully applied to analyze curdione, isocurcumenol, furanodienone, germacrone and furanodiene in Radix Curcumae samples.
    Type of Medium: Online Resource
    ISSN: 1615-9306 , 1615-9314
    URL: Issue
    URL: Article
    DOI: 10.1002/jssc.v44.7
    DOI: 10.1002/jssc.202001067
    RVK:
    VA 5450
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2047990-6
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  • 6
    Online Resource
    Online Resource
    Recent advances on discovery of enzyme inhibitors from natural products using bioactivity screening
    Wiley ; 2022
    In:  Journal of Separation Science Vol. 45, No. 14 ( 2022-07), p. 2766-2787
    Details
    In: Journal of Separation Science, Wiley, Vol. 45, No. 14 ( 2022-07), p. 2766-2787
    Abstract: The essence of enzymes is to keep the homeostasis and balance of humans by catalyzing metabolic responses and modulating cells. Suppression of an enzyme slows the progress of some diseases, making it a therapeutic target. Therefore, it is important to develop enzyme inhibitors by proper bioactivity screening strategies for the future treatment of some major diseases. In this review, we summarized the recent (2015–2020) applications of several screening strategies (electrophoretically mediated microanalysis, enzyme immobilization, affinity chromatography, and affinity ultrafiltration) in finding enzyme inhibitors from certain species of bioactive natural compounds of plant origin (flavonoids, alkaloids, phenolic acids, saponins, anthraquinones, coumarins). At the same time, the advantages and disadvantages of each strategy were also discussed, and the future possible development direction in enzyme inhibitor screening has been prospected. To sum up, it is expected to help readers select suitable screening strategies for enzyme inhibitors and provide useful information for the study of the biological effects of specific kinds of natural products.
    Type of Medium: Online Resource
    ISSN: 1615-9306 , 1615-9314
    URL: Issue
    URL: Article
    DOI: 10.1002/jssc.v45.14
    DOI: 10.1002/jssc.202200084
    RVK:
    VA 5450
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2047990-6
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  • 7
    Online Resource
    Online Resource
    Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells
    Wiley ; 2010
    In:  Journal of Cellular Biochemistry Vol. 109, No. 1 ( 2010-01), p. 236-244
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 109, No. 1 ( 2010-01), p. 236-244
    Abstract: Recently significant progress has been made in differentiating embryonic stem (ES) cells toward pancreatic cells. However, little is known about the generation and identification of pancreatic progenitor cells from ES cells. Here we explored the influence of sodium butyrate on pancreatic progenitor differentiation, and investigated the different effects of sodium butyrate on pancreatic and hepatic progenitor formation. Our results indicated that different concentration and exposure time of sodium butyrate led to different differentiating trends of ES cells. A relatively lower concentration of sodium butyrate with shorter exposure time induced more pancreatic progenitor cell formation. When stimulated by a higher concentration and longer exposure time of sodium butyrate, ES cells differentiated toward hepatic progenitor cells rather than pancreatic progenitor cells. These progenitor cells could further mature into pancreatic and hepatic cells with the supplement of exogenous inducing factors. The resulting pancreatic cells expressed specific markers such as insulin and C‐peptide, and were capable of insulin secretion in response to glucose stimulation. The differentiated hepatocytes were characterized by the expression of a number of liver‐associated genes and proteins, and had the capability of glycogen storage. Thus, the current study demonstrated that sodium butyrate played different roles in inducing ES cells toward pancreatic or hepatic progenitor cells. These progenitor cells could be further induced into mature pancreatic cells and hepatocytes. This finding may facilitate the understanding of pancreatic and hepatic cell differentiation from ES cells, and provide a potential source of transplantable cells for cell‐replacement therapies. J. Cell. Biochem. 109: 236–244, 2010. © 2009 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v109:1
    DOI: 10.1002/jcb.22401
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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