In:
Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 14, No. 1 ( 2011-02-01), p. 94-97
Abstract:
This study aims to determine whether fetal growth is related to insulin-like growth factor-1 in dichorionic and monochorionic twins and also aims to investigate the correlation of insulin-like growth factor-1 to birthweight discordance in twins. We studied 100 women with twin pregnancies. The correlation tests of 36 discordant twins (15 monochorionic, 21 dichorionic) showed correlation between insulin-like growth factor-1 difference and birthweight discordance (insulin-like growth factor-1 vs. birthweight of first twin, r = +0.915, at 0.01 level, IGF-1 vs birthweight of second twin r = +0.790, at 0.01 level). In 49 monochorionic twins, independent of discordance, there was a correlation between birthweight discordance and insulin-like growth factor-1 difference ( r = .538, at the 0.01 level). This correlation was not significant in dichorionic twins, r = .144, p = .01. These data suggest that growth discordances of twins exposed to the same maternal environment may be due to variations in IGF-1, depending upon the genetic similarity.
Type of Medium:
Online Resource
ISSN:
1832-4274
,
1839-2628
DOI:
10.1375/twin.14.1.94
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2011
detail.hit.zdb_id:
2184274-7
SSG:
12
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