In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 637 ( 2022-03-23)
Abstract:
As SARS-CoV-2 variants of concern reduce the effectiveness of existing therapeutics, identifying targets on the virus that remain conserved across variants becomes increasingly important. Here, Zhou et al . identified a human monoclonal antibody isolated from a convalescent donor, CC40.8, that bound to the SARS-CoV-2 S2 stem peptide, a region that is conserved across beta-coronaviruses. CC40.8 protected two animal models from disease after SARS-CoV-2 challenge. The authors also showed that CC40.8-like antibodies are rare in humans after infection with SARS-CoV-2, suggesting that rational structure-based vaccination strategies will be required to elicit these antibodies.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abi9215
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
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