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  • 1
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    Online Resource
    Abstract 1027: Helicobacter pylori blood biomarkers for gastric cancer risk in the Shanghai Men's Health Study
    American Association for Cancer Research (AACR) ; 2012
    In:  Cancer Research Vol. 72, No. 8_Supplement ( 2012-04-15), p. 1027-1027
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 72, No. 8_Supplement ( 2012-04-15), p. 1027-1027
    Abstract: Background: Helicobacter pylori is the leading identified risk factor for distal gastric cancer, yet only a fraction of infected individuals ever develop neoplasia. To identify potential risk markers in a Chinese population where over 90% of individuals are infected with H. pylori, we assessed the association between antibodies to 15 Helicobacter pylori proteins and gastric cancer risk in a case-control study nested in a population-based cohort study. Methods: Each incident distal gastric cancer case (n = 227) identified between 2002 and 2009 among members of the Shanghai Men's Health Study was matched to two controls based on age, timing of blood collection, and recent antibiotic use. Serum levels of antibodies to 15 Helicobacter pylori proteins were assessed using multiplex serology. Multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: Sero-positivity to three (Omp, HP0305, HyuA) of fifteen proteins assessed were associated with an approximate two-fold significantly increased risk for gastric cancer. When excluding cases who were diagnosed within two years of study enrollment (and their matched controls), sero-positivity to two additional proteins (HpaA and NapA) showed significant associations with risk. An association with CagA sero-positivity was also suggested. Compared to individuals with ≤3 sero-positive results to the six virulent proteins identified in this population, individuals with 4-5 sero-positive results were at a two-fold increased risk (OR=1.93, 95% CI: 1.25-3.00) and individuals sero-positive to all 6 proteins had an over 3-fold increase in risk (OR=3.31, 95% CI: 1.86-5.89) for distal gastric cancer. Among individuals least likely to have begun cascade of events leading to gastric cancer, these associations were even stronger (OR=2.74, 95% CI: 1.58-4.73 and OR=4.72, 95% CI: 2.22-10.03, respectively). Conclusions: In the Chinese population, among whom H. pylori-infection is highly prevalent, increasing number of sero-positives to six H. pylori proteins (Omp, HP0305, HyuA, HpaA, CagA, and VacA) may predict the risk of gastric cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1027. doi:1538-7445.AM2012-1027
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2012-1027
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2012
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  • 2
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    Helicobacter pylori blood biomarker for gastric cancer risk in East Asia
    Oxford University Press (OUP) ; 2016
    In:  International Journal of Epidemiology Vol. 45, No. 3 ( 2016-06), p. 774-781
    Details
    In: International Journal of Epidemiology, Oxford University Press (OUP), Vol. 45, No. 3 ( 2016-06), p. 774-781
    Type of Medium: Online Resource
    ISSN: 0300-5771 , 1464-3685
    URL: Article
    DOI: 10.1093/ije/dyw078
    RVK:
    XF 4100
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2016
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  • 3
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    Diet, Helicobacter pylori Strain-Specific Infection, and Gastric Cancer Risk Among Chinese Men
    Informa UK Limited ; 2014
    In:  Nutrition and Cancer Vol. 66, No. 4 ( 2014-05-19), p. 550-557
    Details
    In: Nutrition and Cancer, Informa UK Limited, Vol. 66, No. 4 ( 2014-05-19), p. 550-557
    Type of Medium: Online Resource
    ISSN: 0163-5581 , 1532-7914
    URL: Article
    DOI: 10.1080/01635581.2014.894096
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2014
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  • 4
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    Epstein–Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia
    Springer Science and Business Media LLC ; 2018
    In:  Digestive Diseases and Sciences Vol. 63, No. 10 ( 2018-10), p. 2765-2772
    Details
    In: Digestive Diseases and Sciences, Springer Science and Business Media LLC, Vol. 63, No. 10 ( 2018-10), p. 2765-2772
    Type of Medium: Online Resource
    ISSN: 0163-2116 , 1573-2568
    URL: Article
    DOI: 10.1007/s10620-018-5154-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
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  • 5
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    Helicobacter pylori Protein–Specific Antibodies and Risk of Colorectal Cancer
    American Association for Cancer Research (AACR) ; 2013
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 22, No. 11 ( 2013-11-01), p. 1964-1974
    Details
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 22, No. 11 ( 2013-11-01), p. 1964-1974
    Abstract: Background: There is biologic plausibility as to why infection with Helicobacter pylori, the leading cause of gastric cancer, may also increase the risk of colorectal cancer, but the epidemiologic findings have been inconsistent. We assessed the association of H. pylori protein–specific infection and colorectal cancer risk in the prospective cohort, the Southern Community Cohort Study. Methods: Multiplex serology was used to measure antibodies to 15 H. pylori proteins in prediagnostic blood among 188 incident colorectal cancer cases and 370 controls matched by age, race, sex, and blood collection timing. Conditional logistic regression was used to calculate ORs and 95% confidence intervals (CI). Results: Overall H. pylori prevalence was not associated with colorectal cancer risk (OR, 1.03; 95% CI, 0.59–1.77). However, seropositivity to any of five specific H. pylori proteins (VacA, HP231, HP305, NapA, and HcpC) was associated with a significant 60% to 80% increase in odds of risk. These associations became even stronger when limited to colon cancer risk, particularly for the known H. pylori toxin VacA (OR, 2.24; 95% CI, 1.22–4.11), including a significant, positive dose–response association by VacA antibody levels in quartiles (P & lt; 0.05). Associations with VacA seropositivity were especially strong for early-onset and late-stage cancers. Conclusions: The findings raise the hypothesis that individuals with high levels of antibodies to specific H. pylori proteins may be at higher risk of colon cancer. Impact: Further investigation of the H. pylori–colorectal cancer association is warranted to determine the possibility of protein-specific antibody levels as a risk biomarker. Cancer Epidemiol Biomarkers Prev; 22(11); 1964–74. ©2013 AACR.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    URL: Article
    DOI: 10.1158/1055-9965.EPI-13-0702
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2013
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  • 6
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    Race, African Ancestry, and Helicobacter pylori Infection in a Low-Income United States Population
    American Association for Cancer Research (AACR) ; 2011
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 20, No. 5 ( 2011-05-01), p. 826-834
    Details
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 20, No. 5 ( 2011-05-01), p. 826-834
    Abstract: Background: Gastric cancer incidence in African Americans is twice that of whites, and differing prevalence of Helicobacter pylori strain-specific isolates may help explain the disparity. Methods: Serum levels of antibodies to each of 15 H. pylori proteins were assessed using multiplex serology for a sample of 689 African American and white participants from the Southern Community Cohort Study. African and European admixture was estimated using a panel of 276 ancestry genetic markers, with “low,” “medium,” and “high” categories of African ancestry defined as & lt;85%, 85% to 95%, and ≥95%. Results: The majority (79%) of our study population were sero-positive for H. pylori. African American race was associated with a two- to sixfold increased odds for sero-positivity to eight H. pylori proteins, including the cancer-associated virulence constituents CagA [odds ratio (OR), 6.4; 95% CI, 4.5–9.1], and VacA (OR, 2.3; 95% CI, 1.5–3.5). Compared to whites, African Americans of low, medium, and high African ancestry had 1.6-, 4.1-, and 5.2-fold increased odds of sero-positivity to H. pylori, primarily related to CagA sero-positive strains, for which increasing African ancestry led to 2.5-, 9.6-, and 13.1-fold increased odds. Among African Americans alone, compared to those of low African ancestry, African Americans of medium and high African ancestry had 2.5- and 3.4-fold increased odds of sero-positivity to H. pylori, and 3.5- and 4.9-fold increased odds of CagA sero-positive H. pylori strains. Conclusions: Host genetic variation and/or lifestyle factors associated with African ancestry contribute to the likelihood of infection with H. pylori, particularly its virulent strains, in this low-income U.S. southern population. Impact: Our findings that low-income African Americans of high African ancestry have a particularly high prevalence of antibodies against H. pylori provides a framework for further research into better detection and prevention of gastric cancer in this population. Cancer Epidemiol Biomarkers Prev; 20(5); 826–34. ©2011 AACR.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    URL: Article
    DOI: 10.1158/1055-9965.EPI-10-1258
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2011
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    detail.hit.zdb_id: 1153420-5
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  • 7
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    Helicobacter pylori Prevalence and Circulating Micronutrient Levels in a Low-Income United States Population
    American Association for Cancer Research (AACR) ; 2011
    In:  Cancer Prevention Research Vol. 4, No. 6 ( 2011-06-01), p. 871-878
    Details
    In: Cancer Prevention Research, American Association for Cancer Research (AACR), Vol. 4, No. 6 ( 2011-06-01), p. 871-878
    Abstract: High prevalence of Helicobacter pylori (H. pylori), the leading cause of gastric cancer, and low levels of micronutrients have been observed in many developing countries, and the question remains as to the whether an association between the 2 exists. The present study seeks to further our understanding of this potential connection in the Southern Community Cohort Study, representing a low-income population in the United States. Blood levels of antibodies to H. pylori proteins were assessed by multiplex serology for a sample of 310 African American and white participants, ages 40 to 79 years. Blood collected at baseline was also assayed for levels of carotenoids, tocopherols, retinol, and folate. Multivariate linear regression was used to calculate least-squares mean micronutrient levels within groups defined by H. pylori status. The mean serum levels of all micronutrients assayed were lower among H. pylori + individuals than H. pylori − individuals, significantly for β-carotene, folate, and retinol (decreases of 27.6%, 18.6%, and 9.7%, respectively). Individuals who were seropositive to the virulent CagA+ H. pylori strains had even lower mean levels of micronutrients, particularly β-carotene, folate, total carotenoids, and retinol (decreases of 38.9%, 19.1%, 17.0%, and 11.7%, respectively, compared with H. pylori − individuals). However, dietary micronutrient levels as derived from a food frequency questionnaire did not vary between groups defined by H. pylori status. These results provide support for the hypothesis that H. pylori infection impairs nutrient absorption and suggest a need for future studies to explore the role of H. pylori infection on nutrition and gastric cancer risk in this high-risk population. Cancer Prev Res; 4(6); 871–8. ©2011 AACR.
    Type of Medium: Online Resource
    ISSN: 1940-6207 , 1940-6215
    URL: Article
    DOI: 10.1158/1940-6207.CAPR-10-0398
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2011
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  • 8
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    Circulating cytokines and gastric cancer risk
    Springer Science and Business Media LLC ; 2013
    In:  Cancer Causes & Control Vol. 24, No. 12 ( 2013-12), p. 2245-2250
    Details
    In: Cancer Causes & Control, Springer Science and Business Media LLC, Vol. 24, No. 12 ( 2013-12), p. 2245-2250
    Type of Medium: Online Resource
    ISSN: 0957-5243 , 1573-7225
    URL: Article
    DOI: 10.1007/s10552-013-0284-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2013
    detail.hit.zdb_id: 1496544-6
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  • 9
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    Abstract A84: Race, neighborhood socioeconomic characteristics, and Helicobacter pylori seroprevalence
    American Association for Cancer Research (AACR) ; 2011
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 20, No. 10_Supplement ( 2011-09-01), p. A84-A84
    Details
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 20, No. 10_Supplement ( 2011-09-01), p. A84-A84
    Abstract: Background: Recently, very high Helicobacter pylori sero-prevalence rates were found among African Americans, especially those of higher percentage of African ancestry, residing in the southeastern US. We sought to determine if neighborhood-level socio-economic characteristics, above and beyond individual-level socio-economic characteristics, are associated with Helicobacter pylori prevalence, and, if so, if this helps to explain the strong association with African ancestry. Methods: Antibodies to Helicobacter pylori proteins were assessed in the serum of 665 African American and white participants from the Southern Community Cohort Study. African and European admixture was estimated using a panel of 276 ancestry genetic markers. Prevalence odds ratios for CagA-specific Helicobacter pylori status associated with10 block-level measures of socio-economic status, obtained from linkage to the US Census, were calculated using polytomous logistic regression. Results: After adjusting for individual-level socio-economic characteristics, three neighborhood-level characteristics were significantly inversely related to CagA+ Helicobacter pylori sero-positivity: percent adults completed high school; median value of owner-occupied houses; and percent employed (comparing highest tertile to lowest tertile, OR=0.47, 95%CI: 0.26–0.85; OR=0.56, 95% CI: 0.32–0.99; and OR=0.59, 95% CI: 0.34–1.03, respectively). However, inclusion of these neighborhood-level measures did not attenuate the association of African ancestry and CagA+ Helicobacter pylori sero-prevalence, with African Americans of low, medium, and high African ancestry maintaining 2-, 7-, and 9-fold increased odds compared to whites. Neighborhood levels of education, house values, and employment are associated with sero-prevalence to CagA+Helicobacter pylori, highlighting high-risk areas for prevention and screening efforts, but the strong relationship between African ancestry level and CagA+ Helicobacter pylori sero-prevalence persisted after adjustment for individual and neighborhood-level socio-economic characteristics, suggesting a biological basis for this association. Citation Information: Cancer Epidemiol Biomarkers Prev 2011;20(10 Suppl):A84.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    URL: Article
    DOI: 10.1158/1055-9965.DISP-11-A84
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2011
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    detail.hit.zdb_id: 1153420-5
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  • 10
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    Online Resource
    Prospective Study of Helicobacter pylori Biomarkers for Gastric Cancer Risk among Chinese Men
    American Association for Cancer Research (AACR) ; 2012
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 21, No. 12 ( 2012-12-01), p. 2185-2192
    Details
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 21, No. 12 ( 2012-12-01), p. 2185-2192
    Abstract: Background:Helicobacter pylori is the leading risk factor for gastric cancer, yet only a fraction of infected individuals ever develop neoplasia. Methods: To identify potential predictive biomarkers, we assessed the association of 15 antibodies to H. pylori proteins and gastric cancer in a nested case–control study. Blood levels of antibodies were assessed using multiplex serology for 226 incident cases and 451 matched controls from the Shanghai Men's Health Study. ORs and 95% confidence intervals (CI) were calculated using conditional logistic regression. Results: Seropositivity to four (Omp, HP0305, HyuA, and HpaA) proteins was associated with a 1.5- to 3-fold increased risk for gastric cancer. When excluding cases diagnosed within 2 years of study enrollment, seropositivity to two additional proteins (CagA and VacA) showed significant associations with risk. Compared with individuals with three or fewer seropositive results to the six virulent proteins identified in this population, individuals with four to five seropositive results were at a 2-fold increased risk (OR, 2.08; 95% CI, 1.31–3.30) and individuals seropositive to all six proteins had a 3.5-fold increase in risk (OR, 3.49; 95% CI, 2.00–6.11) for gastric cancer. Among individuals diagnosed at least 2 years after study enrollment, these associations were even stronger (ORs, 2.79 and 4.16, respectively). Conclusions: Increasing number of seropositives to six H. pylori proteins may be a risk marker for distal gastric cancer in China. Impact: In a population with a 90% prevalence of CagA-positive H. pylori infection, assessment of additional virulent H. pylori proteins might better identify individuals at high risk for gastric cancer. Cancer Epidemiol Biomarkers Prev; 21(12); 2185–92. ©2012 AACR.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    URL: Article
    DOI: 10.1158/1055-9965.EPI-12-0792-T
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2012
    detail.hit.zdb_id: 2036781-8
    detail.hit.zdb_id: 1153420-5
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