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Cognitive impairment and dementia in young onset Parkinson’s disease

Santos-García, Diego ; de Deus Fonticoba, Teresa ; Cores Bartolomé, Carlos ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Journal of Neurology

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In: Journal of Neurology, Springer Science and Business Media LLC

Type of Medium: Online Resource

ISSN: 0340-5354 , 1432-1459

URL: Article

DOI: 10.1007/s00415-023-11921-w

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

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Predictors of clinically significant quality of life impairment in Parkinson’s disease

Santos García, Diego ; de Deus Fonticoba, Teresa ; Cores, Carlos ; [et al.]

Springer Science and Business Media LLC ; 2021

In: npj Parkinson's Disease Vol. 7, No. 1 ( 2021-12-16)

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In: npj Parkinson's Disease, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2021-12-16)

Abstract: Quality of life (QOL) plays an important role in independent living in Parkinson’s disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS cohort from January 2016, to November 2017, were followed up during 2 years. Health-related QoL (HRQoL) and global QoL (GQoL) were assessed with the 39-item Parkinson’s disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8), respectively, at baseline (V0) and at 24 months ± 1 month (V2). Clinically significant QoL impairment was defined as presenting an increase (PDQ-39SI) or decrement (EUROHIS-QOL8) at V2 ≥ 10% of the score at baseline (V0). A comparison with a control group was conducted for GQoL. GQoL did not change significantly in PD patients ( N = 507; p = 0.686) or in the control group ( N = 119; p = 0.192). The mean PDQ-39SI was significantly increased in PD patients (62.7 ± 8.5 years old; 58.8% males; N = 500) by 21.6% (from 16.7 ± 13 to 20.3 ± 16.4; p 〈 0.0001) at V2. Ninety-three patients (18.6%) presented a clinically significant HRQoL impairment at V2. To be younger (OR = 0.896; 95% CI 0.829–0.968; p = 0.006), to be a female (OR = 4.181; 95% CI 1.422–12.290; p = 0.009), and to have a greater increase in BDI-II (Beck Depression Inventory-II) (OR = 1.139; 95% CI 1.053–1.231; p = 0.001) and NMSS (Non-Motor Symptoms Scale) (OR = 1.052; 95% CI 1.027–1.113; p 〈 0.0001) total scores from V0 to V2 were associated with clinically significant HRQoL impairment at the 2-year follow-up (Hosmer–Lemeshow test, p = 0.665; R 2 = 0.655). An increase in ≥5 and ≥10 points of BDI-II and NMSS total score at V2 multiplied the probability of presenting clinically significant HRQoL impairment by 5 (OR = 5.453; 95% CI 1.663–17.876; p = 0.005) and 8 (OR = 8.217; 95% CI, 2.975–22.696; p = 0.002), respectively. In conclusion, age, gender, mood, and non-motor impairment were associated with clinically significant HRQoL impairment after the 2-year follow-up in PD patients.

Type of Medium: Online Resource

ISSN: 2373-8057

URL: Article

DOI: 10.1038/s41531-021-00256-w

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

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3

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Predictors of Loss of Functional Independence in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group

Santos García, Diego ; de Deus Fonticoba, Teresa ; Cores Bartolomé, Carlos ; [et al.]

MDPI AG ; 2021

In: Diagnostics Vol. 11, No. 10 ( 2021-09-29), p. 1801-

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In: Diagnostics, MDPI AG, Vol. 11, No. 10 ( 2021-09-29), p. 1801-

Abstract: Background and objective: The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson’s disease (PD) patients versus a control group, as well as to identify predictors of disability progression and functional dependency (FD). Patients and Methods: PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab & England Activities of Daily Living Scale (S & E-ADLS) at V0 and V2. FD was defined as an S & E-ADLS score less than 80%. Results: In the PD group, a significant decrease in the S & E-ADLS score from V0 to V2 (N = 507; from 88.58 ± 10.19 to 84.26 ± 13.38; p 〈 0.0001; Cohen’s effect size = −0.519) was observed but not in controls (N = 124; from 98.87 ± 6.52 to 99.52 ± 2.15; p = 0.238). When only patients considered functional independent at baseline were included, 55 out of 463 (11.9%) converted to functional dependent at V2. To be a female (OR = 2.908; p = 0.009), have longer disease duration (OR = 1.152; p = 0.002), have a non-tremoric motor phenotype at baseline (OR = 3.574; p = 0.004), have a higher score at baseline in FOGQ (OR = 1.244; p 〈 0.0001) and BDI-II (OR = 1.080; p = 0.008), have a lower score at baseline in PD-CRS (OR = 0.963; p = 0.008), and have a greater increase in the score from V0 to V2 in UPDRS-IV (OR = 1.168; p = 0.0.29), FOGQ (OR = 1.348; p 〈 0.0001) and VAFS-Mental (OR = 1.177; p = 0.013) (adjusted R-squared 0.52; Hosmer and Lemeshow test = 0.94) were all found to be independent predictors of FD at V2. Conclusions: In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment, gait problems, fatigue, depressive symptoms, more advanced disease, and a non-tremor phenotype are independent predictors of FD in the short-term.

Type of Medium: Online Resource

ISSN: 2075-4418

URL: Article

DOI: 10.3390/diagnostics11101801

Language: English

Publisher: MDPI AG

Publication Date: 2021

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4

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Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group

Santos-García, Diego ; de Deus Fonticoba, Teresa ; Cores Bartolomé, Carlos ; [et al.]

Hindawi Limited ; 2023

In: Parkinson's Disease Vol. 2023 ( 2023-4-6), p. 1-18

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In: Parkinson's Disease, Hindawi Limited, Vol. 2023 ( 2023-4-6), p. 1-18

Abstract: Introduction. Drooling in Parkinson’s disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. Patients and Methods. PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30-day follow-up (V2) from 35 centers in Spain from the COPPADIS cohort were included in this longitudinal prospective study. Subjects were classified as with or without drooling according to item 19 of the NMSS (Nonmotor Symptoms Scale) at V0, V1 (1-year ± 15 days), and V2 for patients and at V0 and V2 for controls. Results. The frequency of drooling in PD patients was 40.1% (277/691) at V0 (2.4% (5/201) in controls; p 〈 0.0001), 43.7% (264/604) at V1, and 48.2% (242/502) at V2 (3.2% (4/124) in controls; p 〈 0.0001), with a period prevalence of 63.6% (306/481). Being older (OR = 1.032; p = 0.012), being male (OR = 2.333; p 〈 0.0001), having greater nonmotor symptom (NMS) burden at the baseline (NMSS total score at V0; OR = 1.020; p 〈 0.0001), and having a greater increase in the NMS burden from V0 to V2 (change in the NMSS total score from V0 to V2; OR = 1.012; p 〈 0.0001) were identified as independent predictors of drooling after the 2-year follow-up. Similar results were observed in the group of patients with ≤2 years since symptom onset, with a cumulative prevalence of 64.6% and a higher score on the UPDRS-III at V0 (OR = 1.121; p = 0.007) as a predictor of drooling at V2. Conclusion. Drooling is frequent in PD patients even at the initial onset of the disease and is associated with a greater motor severity and NMS burden.

Type of Medium: Online Resource

ISSN: 2042-0080 , 2090-8083

URL: Article

DOI: 10.1155/2023/3104425

Language: English

Publisher: Hindawi Limited

Publication Date: 2023

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5

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Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life

Santos-García, Diego ; de Deus Fonticoba, Teresa ; Cores Bartolomé, Carlos ; [et al.]

IOS Press ; 2023

In: Journal of Parkinson's Disease Vol. 13, No. 3 ( 2023-05-09), p. 379-402

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In: Journal of Parkinson's Disease, IOS Press, Vol. 13, No. 3 ( 2023-05-09), p. 379-402

Abstract: Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort fromJanuary 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL:1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05±7.84 years old; 59% males) were included. MNCD stage was:stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advancedMNCD stage was associated with a higher score on the PDQ39SI (p 〈 0.0001) and a lower score on the PQ-10 (p 〈 0.0001) and EUROHIS-QOL8 (p 〈 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD.

Type of Medium: Online Resource

ISSN: 1877-7171 , 1877-718X

URL: Article

DOI: 10.3233/JPD-225073

Language: Unknown

Publisher: IOS Press

Publication Date: 2023

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6

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Suicidal ideation among people with Parkinson's disease and comparison with a control group

Santos‐García, Diego ; de Deus Fonticoba, Teresa ; Cores Bartolomé, Carlos ; [et al.]

Wiley ; 2023

In: International Journal of Geriatric Psychiatry Vol. 38, No. 5 ( 2023-05)

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In: International Journal of Geriatric Psychiatry, Wiley, Vol. 38, No. 5 ( 2023-05)

Abstract: This study detected suicidal ideation in about 5% of people with Parkinson's disease (PwPD) and was not more frequent than in controls. Independent factors associated with suicidal ideation were major depression, a worse quality of life, and an increase in mood impairment or comorbidity over time. These findings suggest the importance of detecting depressive symptoms in PwPD and evaluation for suicide thoughts, especially in those PwPD with major depression.

Type of Medium: Online Resource

ISSN: 0885-6230 , 1099-1166

URL: Issue

URL: Article

DOI: 10.1002/gps.v38.5

DOI: 10.1002/gps.5919

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XA 10000

Language: English

Publisher: Wiley

Publication Date: 2023

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7

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Constipation Predicts Cognitive Decline in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-up and Comparison with a Control Group

Santos García, Diego ; García Roca, Lucía ; de Deus Fonticoba, Teresa ; [et al.]

IOS Press ; 2022

In: Journal of Parkinson's Disease Vol. 12, No. 1 ( 2022-01-21), p. 315-331

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In: Journal of Parkinson's Disease, IOS Press, Vol. 12, No. 1 ( 2022-01-21), p. 315-331

Abstract: Background: Constipation has been linked to cognitive impairment development in Parkinson’s disease (PD). Objective: Our aim was to analyze cognitive changes observed in PD patients and controls from a Spanish cohort with regards to the presence or not of constipation. Methods: PD patients and controls recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017 were followed-up during 2 years. The change in cognitive status from baseline (V0) to 2-year follow-up was assessed with the PD-CRS (Parkinson’s Disease Cognitive Rating Scale). Subjects with a score ≥1 on item 21 of the NMSS (Non-Motor Symptoms Scale) at baseline (V0) were considered as “with constipation”. Regression analyses were applied for determining the contribution of constipation in cognitive changes. Results: At V0, 39.7% (198/499) of PD patients presented constipation compared to 11.4% of controls (14/123) (p 〈 0.0001). No change was observed in cognitive status (PD-CRS total score) neither in controls without constipation (from 100.24±13.72 to 100.27±13.68; p = 0.971) and with constipation (from 94.71±10.96 to 93.93±13.03; p = 0.615). The PD-CRS total score decreased significantly in PD patients with constipation (from 89.14±15.36 to 85.97±18.09; p 〈 0.0001; Coehn’s effect = –0.35) compared to patients without constipation (from 93.92±15.58 to 93.14±17.52; p = 0.250) (p = 0.018). In PD patients, to suffer from constipation at V0 was associated with a decrease in the PD-CRS total score from V0 to V2 (β= –0.1; 95% CI, –4.36 – –0.27; p = 0.026) and having cognitive impairment at V2 (OR = 1.79; 95% CI, 1.01 – 3.17; p = 0.045). Conclusion: Constipation is associated with cognitive decline in PD patients but not in controls.

Type of Medium: Online Resource

ISSN: 1877-7171 , 1877-718X

URL: Article

DOI: 10.3233/JPD-212868

Language: Unknown

Publisher: IOS Press

Publication Date: 2022

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8

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Mood in Parkinson's disease: From early‐ to late‐stage disease

Santos‐García, Diego ; De Deus, Fonticoba T. ; Cores, Bartolome C. ; [et al.]

Wiley ; 2021

In: International Journal of Geriatric Psychiatry Vol. 36, No. 5 ( 2021-05), p. 627-646

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In: International Journal of Geriatric Psychiatry, Wiley, Vol. 36, No. 5 ( 2021-05), p. 627-646

Abstract: Although depression is known to be frequent in Parkinson's disease (PD), it is unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was to analyze the frequency of depression, mood related factors and the contribution of mood to a patient's QoL perception in regard to disease duration. Methods PD patients recruited from the COPPADIS cohort from January 2016 to November 2017 were included in this cross‐sectional study. Three groups were defined: 〈 5 years (Group A); from 5 to 〈 10 years (Group B); ≥10 years (Group C). Analysis with well‐planned linear regression models was conducted to determine how different factors contribute to mood (Beck Depression Inventory‐II [BDI‐II] as dependent variable), to health‐related QoL (39‐item Parkinson's Disease Questionnaire [PDQ‐39SI] as dependent variable) and to global QoL (European Health Interview Survey – Quality of Life Eight‐Item Index [EUROHIS‐QOL8] as dependent variable). Results Six hundred and sixty‐three PD patients (62.6 ± 8.9 years old, 59.6% males) were included: Group A, 50.1% ( n = 332); Group B, 33.3% ( n = 221) and Group C, 16.6% ( n = 110). There were no differences between the three groups in terms of the frequency of depressive symptoms nor the frequency of depression type (major vs. minor vs. subthreshold) ( p = 0.729). However, the unique percent variance of PDQ‐39SI and EUROHIS‐QOL8 explained by BDI‐II total score was 2 (23.7%) and threefold (26.9%), respectively, in Group C compared to the other two groups. EUROHIS‐QOL8 total score provided the highest unique contribution to mood (16.8%). Conclusions Although depression‐type frequency does not appear to change over time in PD; the contribution of mood on QoL perception is greater in patients with longer disease duration.

Type of Medium: Online Resource

ISSN: 0885-6230 , 1099-1166

URL: Issue

URL: Article

DOI: 10.1002/gps.v36.5

DOI: 10.1002/gps.5461

RVK:

XA 10000

Language: English

Publisher: Wiley

Publication Date: 2021

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Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Study

Santos-García, Diego ; de Deus Fonticoba, Teresa ; Bartolomé, Carlos Cores ; [et al.]

MDPI AG ; 2022

In: Diagnostics Vol. 12, No. 5 ( 2022-05-05), p. 1147-

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In: Diagnostics, MDPI AG, Vol. 12, No. 5 ( 2022-05-05), p. 1147-

Abstract: Objective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson’s disease (PD) patients regarding the development of motor fluctuations (MF). Methods: PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated again at a 2-year follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this analysis. MF development at V2 was defined as a score ≥ 1 in the item-39 of the UPDRS-Part IV, whereas NMS burden was defined according to the Non-motor Symptoms Scale (NMSS) total score. Results: Three hundred and thirty PD patients (62.67 ± 8.7 years old; 58.8% males) were included. From V0 to V2, 27.6% of the patients developed MF. The mean NMSS total score at baseline was higher in those patients who developed MF after the 2-year follow-up (46.34 ± 36.48 vs. 34.3 ± 29.07; p = 0.001). A greater increase in the NMSS total score from V0 to V2 was observed in patients who developed MF (+16.07 ± 37.37) compared to those who did not develop MF (+6.2 ± 25.8) (p = 0.021). Development of MF after a 2-year follow-up was associated with an increase in the NMSS total score (β = 0.128; p = 0.046) after adjustment to age, gender, years from symptoms onset, levodopa equivalent daily dose (LEDD) and the NMSS total score at baseline, and the change in LEDD from V0 to V2. Conclusions: In PD patients, the development of MF is associated with a greater increase in the NMS burden after a 2-year follow-up.

Type of Medium: Online Resource

ISSN: 2075-4418

URL: Article

DOI: 10.3390/diagnostics12051147

Language: English

Publisher: MDPI AG

Publication Date: 2022

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10

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Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up

Santos García, Diego ; Naya Ríos, Lucía ; de Deus Fonticoba, Teresa ; [et al.]

MDPI AG ; 2021

In: Diagnostics Vol. 11, No. 12 ( 2021-12-17), p. 2380-

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In: Diagnostics, MDPI AG, Vol. 11, No. 12 ( 2021-12-17), p. 2380-

Abstract: Background and objective: Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare the frequency with a control group, and to identify factors associated with it. Patients and Methods: PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort were included in this longitudinal prospective study. The patients and controls were classified as “with diplopia” or “without diplopia” according to item 15 of the Non-Motor Symptoms Scale (NMSS) at V0, V1 (1-year ± 15 days), and V2 for the patients and at V0 and V2 for the controls. Results: The frequency of diplopia in the PD patients was 13.6% (94/691) at V0 (1.9% in controls [4/206]; p 〈 0.0001), 14.2% (86/604) at V1, and 17.1% (86/502) at V2 (0.8% in controls [1/124]; p 〈 0.0001), with a period prevalence of 24.9% (120/481). Visual hallucinations at any visit from V0 to V2 (OR = 2.264; 95%CI, 1.269–4.039; p = 0.006), a higher score on the NMSS at V0 (OR = 1.009; 95%CI, 1.012–1.024; p = 0.015), and a greater increase from V0 to V2 on the Unified Parkinson’s Disease Rating Scale–III (OR = 1.039; 95%CI, 1.023–1.083; p 〈 0.0001) and Neuropsychiatric Inventory (OR = 1.028; 95%CI, 1.001–1.057; p = 0.049) scores were independent factors associated with diplopia (R2 = 0.25; Hosmer and Lemeshow test, p = 0.716). Conclusions: Diplopia represents a frequent symptom in PD patients and is associated with motor and non-motor severity.

Type of Medium: Online Resource

ISSN: 2075-4418

URL: Article

DOI: 10.3390/diagnostics11122380

Language: English

Publisher: MDPI AG

Publication Date: 2021

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