In:
Australian & New Zealand Journal of Psychiatry, SAGE Publications, Vol. 10, No. 1 ( 1976-03), p. 7-12
Abstract:
A double-isotope derivative dilution procedure for measuring plasma levels of Nortriptyline is described. The assay is specific, sensitive, precise and reproducible. Studies on the variation in steady-state plasma levels are described on a fixed oral dosage of nortriptyline. Between individual variations in steady-state plasma levels are large. Between day within individual variation is 15–20%. Dosage regime, time of blood sampling after hist oral dose and the method of blood handling are unlikely to affect the steady-state plasma levels. Within an individual, the oral dose, duration of treatment and concomitant drug treatment are all important determinants of the steady-state plasma level.
Type of Medium:
Online Resource
ISSN:
0004-8674
,
1440-1614
DOI:
10.3109/00048677609159479
Language:
English
Publisher:
SAGE Publications
Publication Date:
1976
detail.hit.zdb_id:
2003849-5
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